Pattern recognition receptors in health and diseases

• Published in: Signal transduction and targeted therapy Vol. 6; no. 1; pp. 291 - 24
• Main Authors: Li, Danyang, Wu, Minghua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.08.2021; Nature Publishing Group
• Subjects: 631/250/262; 631/535; 631/67/1059/153; Animals; Antitumor activity; Apoptosis; Apoptosis - genetics; Cancer Research; Cell Biology; Cellular Senescence - genetics; Clinical trials; DEAD Box Protein 58 - genetics; Homology; Host-Pathogen Interactions - genetics; Humans; Immune system; Immunity, Innate - genetics; Immunosuppressive agents; Inflammation - genetics; Inflammation - pathology; Innate immunity; Internal Medicine; Lectins, C-Type - genetics; Ligands; Medicine; Medicine & Public Health; Melanoma; NLR Proteins - genetics; Oligomerization; Oncology; Pathology; Pattern recognition; Pattern recognition receptors; Receptors, Immunologic - genetics; Receptors, Pattern Recognition - genetics; Retinoic acid; Review; Review Article; Signal transduction; Toll-like receptors; Toll-Like Receptors - genetics; Tumors

Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged senescent cells. PRRs bridge nonspecific immunity and specific immunity. Through the recognition and binding of l...