Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset Still’s disease pathogenesis

• Published in: Nature communications Vol. 13; no. 1; pp. 6804 - 17
• Main Authors: Jia, Jinchao, Wang, Mengyan, Meng, Jianfen, Ma, Yuning, Wang, Yang, Miao, Naijun, Teng, Jialin, Zhu, Dehao, Shi, Hui, Sun, Yue, Liu, Honglei, Cheng, Xiaobing, Su, Yutong, Ye, Junna, Chi, Huihui, Liu, Tingting, Zhou, Zhuochao, Wan, Liyan, Chen, Xia, Wang, Fan, Zhang, Hao, Ben, Jingjing, Wang, Jing, Yang, Chengde, Hu, Qiongyi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.11.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/21; 13/31; 13/51; 14; 14/19; 14/34; 14/63; 38/88; 38/90; 38/91; 631/250/249/2510; 631/250/2504/223/1699; 631/80/304; 692/4023/1670; 82/29; Ablation; Animal models; Animals; Cell activation; Cell surface; COVID-19; Cytokine Release Syndrome; Cytokine storm; Cytokines; Depletion; Elastase; Extracellular Traps - metabolism; Ferritin; Ferritins - metabolism; Humanities and Social Sciences; Inflammation; Inflammation - metabolism; Leukocytes; Leukocytes (neutrophilic); Mice; multidisciplinary; Neutrophils; Pathogenesis; Protein-arginine deiminase; Reactive oxygen species; Scavenger Receptors, Class A - metabolism; Science; Science (multidisciplinary); Signal transduction; Still's Disease, Adult-Onset - metabolism

Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of ferritin remains largely unknown. Here we show in an animal model that ferritin administration leads to systemic...