Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

• Published in: Nature communications Vol. 11; no. 1; pp. 1628 - 9
• Main Authors: Marnetto, Davide, Pärna, Katri, Läll, Kristi, Molinaro, Ludovica, Montinaro, Francesco, Haller, Toomas, Metspalu, Mait, Mägi, Reedik, Fischer, Krista, Pagani, Luca
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.04.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/2413; 631/208/205; 631/208/457/649; Bias; Deconvolution; Genealogy; Genetic Predisposition to Disease; Genetics, Population; Genomes; Genotype; Humanities and Social Sciences; Humans; Models, Genetic; multidisciplinary; Multifactorial Inheritance; Phenotype; Phenotypes; Polygenic inheritance; Population; Population genetics; Populations; Precision medicine; Predictions; Science; Science (multidisciplinary)

Polygenic Scores (PSs) describe the genetic component of an individual’s quantitative phenotype or their susceptibility to diseases with a genetic basis. Currently, PSs rely on population-dependent contributions of many associated alleles, with limited applicability to understudied populations and r...