Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis

• Published in: Nature communications Vol. 9; no. 1; pp. 5288 - 16
• Main Authors: Rudkin, Fiona M., Raziunaite, Ingrida, Workman, Hillary, Essono, Sosthene, Belmonte, Rodrigo, MacCallum, Donna M., Johnson, Elizabeth M., Silva, Lisete M., Palma, Angelina S., Feizi, Ten, Jensen, Allan, Erwig, Lars P., Gow, Neil A. R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.12.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/106; 14; 14/1; 42; 42/109; 42/47; 49; 49/61; 631/154/51/1568; 631/250/255/1672; 631/326/2521; 64; 64/60; Animal models; Animals; Antibodies, Fungal - administration & dosage; Antibodies, Fungal - genetics; Antibodies, Fungal - immunology; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - genetics; Antibodies, Monoclonal - immunology; Avidity; B-Lymphocytes - immunology; Candida; Candida albicans - drug effects; Candida albicans - physiology; Candidiasis; Candidiasis - immunology; Candidiasis - microbiology; Candidiasis - prevention & control; Cell walls; Chemotherapy; Cytology; Diagnostic systems; Female; Fungi; Genes; Humanities and Social Sciences; Humans; Immunoglobulin G; Immunoglobulins; Immunological memory; Kidneys; Lymphocytes B; Macrophages; Memory cells; Mice; Mice, Inbred BALB C; Monoclonal antibodies; Morphology; multidisciplinary; Phagocytes; Phagocytosis; Proteins; Science; Science (multidisciplinary); Vaccines

The high global burden of over one million annual lethal fungal infections reflects a lack of protective vaccines, late diagnosis and inadequate chemotherapy. Here, we have generated a unique set of fully human anti- Candida monoclonal antibodies (mAbs) with diagnostic and therapeutic potential by e...