A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses

• Published in: Nature communications Vol. 9; no. 1; pp. 1230 - 12
• Main Authors: Prow, Natalie A., Liu, Liang, Nakayama, Eri, Cooper, Tamara H., Yan, Kexin, Eldi, Preethi, Hazlewood, Jessamine E., Tang, Bing, Le, Thuy T., Setoh, Yin Xiang, Khromykh, Alexander A, Hobson-Peters, Jody, Diener, Kerrilyn R., Howley, Paul M., Hayball, John D., Suhrbier, Andreas
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.03.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/106; 14/63; 45/77; 631/326/590; 631/326/596/1282; 631/326/596/1746; 692/308/1426; 82/1; 82/29; 96/106; Animals; Antibodies; Antibodies, Neutralizing - biosynthesis; Aquatic insects; Arthritis; Cassettes; Cercopithecus aethiops; Chikungunya Fever - immunology; Chikungunya Fever - prevention & control; Chikungunya virus; Chikungunya virus - immunology; CHO Cells; Cricetulus; Disease transmission; Enzyme-Linked Immunosorbent Assay; Epidemics; Female; Fetuses; Flavivirus; Genetic Vectors; HeLa Cells; Humanities and Social Sciences; Humans; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Mosquitoes; multidisciplinary; Pathogens; Placenta; Polyproteins; Pregnancy; Receptor, Interferon alpha-beta - genetics; Science; Science (multidisciplinary); Testes; Vaccination; Vaccines; Vaccinia; Vaccinia virus - genetics; Vector-borne diseases; Vero Cells; Viral Vaccines - administration & dosage; Viral Vaccines - genetics; Viral Vaccines - immunology; Viremia; Viruses; Zika virus; Zika Virus - immunology; Zika Virus Infection - immunology; Zika Virus Infection - prevention & control

Zika and chikungunya viruses have caused major epidemics and are transmitted by Aedes aegypti and/or Aedes albopictu s mosquitoes. The “Sementis Copenhagen Vector” (SCV) system is a recently developed vaccinia-based, multiplication-defective, vaccine vector technology that allows manufacture in modi...