A genome-wide association study identifies three new risk loci for Kawasaki disease

• Published in: Nature genetics Vol. 44; no. 5; pp. 517 - 521
• Main Authors: Onouchi, Yoshihiro, Ozaki, Kouichi, Burns, Jane C, Shimizu, Chisato, Terai, Masaru, Hamada, Hiromichi, Honda, Takafumi, Suzuki, Hiroyuki, Suenaga, Tomohiro, Takeuchi, Takashi, Yoshikawa, Norishige, Suzuki, Yoichi, Yasukawa, Kumi, Ebata, Ryota, Higashi, Kouji, Saji, Tsutomu, Kemmotsu, Yasushi, Takatsuki, Shinichi, Ouchi, Kazunobu, Kishi, Fumio, Yoshikawa, Tetsushi, Nagai, Toshiro, Hamamoto, Kunihiro, Sato, Yoshitake, Honda, Akihito, Kobayashi, Hironobu, Sato, Junichi, Shibuta, Shoichi, Miyawaki, Masakazu, Oishi, Ko, Yamaga, Hironobu, Aoyagi, Noriyuki, Iwahashi, Seiji, Miyashita, Ritsuko, Murata, Yuji, Sasago, Kumiko, Takahashi, Atsushi, Kamatani, Naoyuki, Kubo, Michiaki, Tsunoda, Tatsuhiko, Hata, Akira, Nakamura, Yusuke, Tanaka, Toshihiro
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.05.2012; Nature Publishing Group
• Subjects: 631/208/205/2138; 631/208/2489/144; 631/250/249/1313; Agriculture; Aneurysms; Animal Genetics and Genomics; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Disease; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic Loci; Genetic Markers; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Human Genetics; Humans; Immunoglobulins; letter; Medical sciences; Mucocutaneous Lymph Node Syndrome - genetics; Polymorphism, Single Nucleotide - genetics; Receptors, IgG - genetics; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Studies; Vascular disease; Kawasaki syndrome; Immunopathology; Vasculitis; Association; Systemic disease; Autoimmune disease; Cardiovascular disease; Risk; Identification; Locus

Yoshihiro Onouchi and colleagues report the results of a genome-wide association study of Kawasaki disease. They identify three new risk loci, all mapping near genes previously implicated in adult-onset autoimmune diseases. We performed a genome-wide association study (GWAS) of Kawasaki disease in J...