A genome-wide association study identifies three new risk loci for Kawasaki disease
Yoshihiro Onouchi and colleagues report the results of a genome-wide association study of Kawasaki disease. They identify three new risk loci, all mapping near genes previously implicated in adult-onset autoimmune diseases. We performed a genome-wide association study (GWAS) of Kawasaki disease in J...
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| Published in | Nature genetics Vol. 44; no. 5; pp. 517 - 521 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.05.2012
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Yoshihiro Onouchi and colleagues report the results of a genome-wide association study of Kawasaki disease. They identify three new risk loci, all mapping near genes previously implicated in adult-onset autoimmune diseases.
We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the
FAM167A
-
BLK
region at 8p22-23 (rs2254546,
P
= 8.2 × 10
−21
), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151,
P
= 4.6 × 10
−11
) and in the
CD40
region at 20q13 (rs4813003,
P
= 4.8 × 10
−8
). We also replicated the association of a functional SNP of
FCGR2A
(rs1801274,
P
= 1.6 × 10
−6
) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease. |
|---|---|
| AbstractList | We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 × 10(-21)), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10(-11)) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10(-8)). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease. We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 x [10.sup.-21]), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 x [10.sup.-11]) and in the CD40 region at 20q13 (rs4813003, P = 4.8 x [10.sup.-8]). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 x [10.sup.-6]) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease. We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 × 10(-21)), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10(-11)) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10(-8)). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease.We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 × 10(-21)), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10(-11)) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10(-8)). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease. We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 × 10^sup -21^), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10^sup -11^) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10^sup -8^). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10^sup -6^) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease. [PUBLICATION ABSTRACT] We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 x 10 super(-21)), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 x 10 super(-11)) and in the CD40 region at 20q13 (rs4813003, P = 4.8 x 10 super(-8)). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 x 10 super(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease. Yoshihiro Onouchi and colleagues report the results of a genome-wide association study of Kawasaki disease. They identify three new risk loci, all mapping near genes previously implicated in adult-onset autoimmune diseases. We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A - BLK region at 8p22-23 (rs2254546, P = 8.2 × 10 −21 ), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10 −11 ) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10 −8 ). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10 −6 ) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease. |
| Audience | Academic |
| Author | Yoshikawa, Norishige Yoshikawa, Tetsushi Suzuki, Yoichi Honda, Takafumi Oishi, Ko Takatsuki, Shinichi Suenaga, Tomohiro Murata, Yuji Ozaki, Kouichi Takahashi, Atsushi Kubo, Michiaki Sato, Yoshitake Nakamura, Yusuke Hamamoto, Kunihiro Tsunoda, Tatsuhiko Terai, Masaru Yasukawa, Kumi Sato, Junichi Honda, Akihito Burns, Jane C Onouchi, Yoshihiro Suzuki, Hiroyuki Takeuchi, Takashi Kishi, Fumio Shibuta, Shoichi Higashi, Kouji Miyawaki, Masakazu Yamaga, Hironobu Kamatani, Naoyuki Saji, Tsutomu Aoyagi, Noriyuki Iwahashi, Seiji Ebata, Ryota Miyashita, Ritsuko Hamada, Hiromichi Shimizu, Chisato Sasago, Kumiko Kemmotsu, Yasushi Hata, Akira Tanaka, Toshihiro Ouchi, Kazunobu Nagai, Toshiro Kobayashi, Hironobu |
| Author_xml | – sequence: 1 givenname: Yoshihiro surname: Onouchi fullname: Onouchi, Yoshihiro email: onouchi@src.riken.jp organization: Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Department of Public Health, Chiba University Graduate School of Medicine – sequence: 2 givenname: Kouichi surname: Ozaki fullname: Ozaki, Kouichi organization: Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN – sequence: 3 givenname: Jane C surname: Burns fullname: Burns, Jane C organization: Department of Pediatrics, School of Medicine, University of California, San Diego, Department of Pediatrics, Rady Children's Hospital San Diego – sequence: 4 givenname: Chisato surname: Shimizu fullname: Shimizu, Chisato organization: Department of Pediatrics, School of Medicine, University of California, San Diego, Department of Pediatrics, Rady Children's Hospital San Diego – sequence: 5 givenname: Masaru surname: Terai fullname: Terai, Masaru organization: Department of Pediatrics, Tokyo Women's Medical University, Yachiyo Medical Center – sequence: 6 givenname: Hiromichi surname: Hamada fullname: Hamada, Hiromichi organization: Department of Pediatrics, Tokyo Women's Medical University, Yachiyo Medical Center – sequence: 7 givenname: Takafumi surname: Honda fullname: Honda, Takafumi organization: Department of Pediatrics, Tokyo Women's Medical University, Yachiyo Medical Center – sequence: 8 givenname: Hiroyuki surname: Suzuki fullname: Suzuki, Hiroyuki organization: Department of Pediatrics, Wakayama Medical University – sequence: 9 givenname: Tomohiro surname: Suenaga fullname: Suenaga, Tomohiro organization: Department of Pediatrics, Wakayama Medical University – sequence: 10 givenname: Takashi surname: Takeuchi fullname: Takeuchi, Takashi organization: Department of Pediatrics, Wakayama Medical University – sequence: 11 givenname: Norishige surname: Yoshikawa fullname: Yoshikawa, Norishige organization: Department of Pediatrics, Wakayama Medical University – sequence: 12 givenname: Yoichi surname: Suzuki fullname: Suzuki, Yoichi organization: Department of Public Health, Chiba University Graduate School of Medicine – sequence: 13 givenname: Kumi surname: Yasukawa fullname: Yasukawa, Kumi organization: Department of Pediatrics, Tokyo Women's Medical University, Yachiyo Medical Center – sequence: 14 givenname: Ryota surname: Ebata fullname: Ebata, Ryota organization: Department of Pediatrics, Chiba University Graduate School of Medicine – sequence: 15 givenname: Kouji surname: Higashi fullname: Higashi, Kouji organization: Department of Pediatrics, Chiba University Graduate School of Medicine – sequence: 16 givenname: Tsutomu surname: Saji fullname: Saji, Tsutomu organization: Department of Pediatrics, Toho University School of Medicine – sequence: 17 givenname: Yasushi surname: Kemmotsu fullname: Kemmotsu, Yasushi organization: Department of Pediatrics, Toho University School of Medicine – sequence: 18 givenname: Shinichi surname: Takatsuki fullname: Takatsuki, Shinichi organization: Department of Pediatrics, Toho University School of Medicine – sequence: 19 givenname: Kazunobu surname: Ouchi fullname: Ouchi, Kazunobu organization: Department of Pediatrics, Kawasaki Medical School – sequence: 20 givenname: Fumio surname: Kishi fullname: Kishi, Fumio organization: Department of Molecular Genetics, Kawasaki Medical School – sequence: 21 givenname: Tetsushi surname: Yoshikawa fullname: Yoshikawa, Tetsushi organization: Department of Pediatrics, Fujita Health University – sequence: 22 givenname: Toshiro surname: Nagai fullname: Nagai, Toshiro organization: Department of Pediatrics, Dokkyo Medical University Koshigaya Hospital – sequence: 23 givenname: Kunihiro surname: Hamamoto fullname: Hamamoto, Kunihiro organization: Department of Occupational Therapy, International University of Health and Welfare – sequence: 24 givenname: Yoshitake surname: Sato fullname: Sato, Yoshitake organization: Department of Pediatrics, Fuji Heavy Industry, Health Insurance Society General Ohta Hospital – sequence: 25 givenname: Akihito surname: Honda fullname: Honda, Akihito organization: Department of Pediatrics, Asahi General Hospital – sequence: 26 givenname: Hironobu surname: Kobayashi fullname: Kobayashi, Hironobu organization: Department of Pediatrics, Asahi General Hospital – sequence: 27 givenname: Junichi surname: Sato fullname: Sato, Junichi organization: Department of Pediatrics, Funabashi Municipal Medical Center – sequence: 28 givenname: Shoichi surname: Shibuta fullname: Shibuta, Shoichi organization: Department of Pediatrics, Social Insurance Kinan Hospital – sequence: 29 givenname: Masakazu surname: Miyawaki fullname: Miyawaki, Masakazu organization: Department of Pediatrics, Social Insurance Kinan Hospital – sequence: 30 givenname: Ko surname: Oishi fullname: Oishi, Ko organization: Department of Pediatrics, Hashimoto Municipal Hospital – sequence: 31 givenname: Hironobu surname: Yamaga fullname: Yamaga, Hironobu organization: Department of Pediatrics, Naga Hospital – sequence: 32 givenname: Noriyuki surname: Aoyagi fullname: Aoyagi, Noriyuki organization: Department of Pediatrics, Wakayama Rosai Hospital – sequence: 33 givenname: Seiji surname: Iwahashi fullname: Iwahashi, Seiji organization: Department of Pediatrics, Hidaka General Hospital – sequence: 34 givenname: Ritsuko surname: Miyashita fullname: Miyashita, Ritsuko organization: Department of Pediatrics, Izumiotsu Municipal Hospital – sequence: 35 givenname: Yuji surname: Murata fullname: Murata, Yuji organization: Department of Pediatrics, Sendai City Hospital – sequence: 36 givenname: Kumiko surname: Sasago fullname: Sasago, Kumiko organization: Department of Public Health, Chiba University Graduate School of Medicine – sequence: 37 givenname: Atsushi surname: Takahashi fullname: Takahashi, Atsushi organization: Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN – sequence: 38 givenname: Naoyuki surname: Kamatani fullname: Kamatani, Naoyuki organization: Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN – sequence: 39 givenname: Michiaki surname: Kubo fullname: Kubo, Michiaki organization: Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN – sequence: 40 givenname: Tatsuhiko surname: Tsunoda fullname: Tsunoda, Tatsuhiko organization: Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN – sequence: 41 givenname: Akira surname: Hata fullname: Hata, Akira organization: Department of Public Health, Chiba University Graduate School of Medicine – sequence: 42 givenname: Yusuke surname: Nakamura fullname: Nakamura, Yusuke organization: Laboratory for Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo – sequence: 43 givenname: Toshihiro surname: Tanaka fullname: Tanaka, Toshihiro organization: Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN |
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| Snippet | Yoshihiro Onouchi and colleagues report the results of a genome-wide association study of Kawasaki disease. They identify three new risk loci, all mapping near... We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and... |
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| SubjectTerms | 631/208/205/2138 631/208/2489/144 631/250/249/1313 Agriculture Aneurysms Animal Genetics and Genomics Asian Continental Ancestry Group - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Disease Fundamental and applied biological sciences. Psychology Gene Function Genetic Loci Genetic Markers Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Human Genetics Humans Immunoglobulins letter Medical sciences Mucocutaneous Lymph Node Syndrome - genetics Polymorphism, Single Nucleotide - genetics Receptors, IgG - genetics Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Studies |
| Title | A genome-wide association study identifies three new risk loci for Kawasaki disease |
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