The role of SET/I2PP2A in canine mammary tumors

• Published in: Scientific reports Vol. 7; no. 1; pp. 4279 - 11
• Main Authors: Kake, Satoru, Tsuji, Shunya, Enjoji, Shuhei, Hanasaki, Sayaka, Hayase, Hiroshi, Yabe, Ryotaro, Tanaka, Yuiko, Nakagawa, Takayuki, Liu, Hao-Ping, Chang, Shih-Chieh, Usui, Tatsuya, Ohama, Takashi, Sato, Koichi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.06.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/109; 13/95; 38/89; 631/67/1347; 692/4028/67/1244; 82/80; Animals; Bortezomib; Breast cancer; Carboplatin; Cell Line, Tumor; Cell proliferation; Disease Models, Animal; Dogs; Doxorubicin; Female; Gene Knockdown Techniques; Heterografts; Humanities and Social Sciences; M cells; Male; Mammary gland; Mammary Neoplasms, Animal - genetics; Mammary Neoplasms, Animal - metabolism; Mammary Neoplasms, Animal - pathology; Mice; Mice, Transgenic; multidisciplinary; Neoplasia; Neoplasm Staging; NF-κB protein; Oncogene Proteins - genetics; Oncogene Proteins - metabolism; Phosphatase; Phosphoprotein phosphatase; Protein phosphatase; Proteins; Science; Science (multidisciplinary); Tamoxifen; TOR protein; Tumor suppressor genes; Tumors; X-rays; β-Catenin

Canine mammary tumor is the most common neoplasm in female dogs, and it has generated considerable attention as a translational model for human breast cancer. Ser/Thr protein phosphatase 2A (PP2A) plays a critical role as a tumor suppressor, and SET/I2PP2A, the endogenous inhibitory protein of PP2A,...