Crucial Role of Drosophila Neurexin in Proper Active Zone Apposition to Postsynaptic Densities, Synaptic Growth, and Synaptic Transmission
Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition. However, key evidence for this role in vivo has been lacking, particularly due to gene redundancy. Here, we have obtained null mutations in the single Drosophila neurexin gene ( dnrx). dn...
Saved in:
Published in | Neuron (Cambridge, Mass.) Vol. 55; no. 5; pp. 741 - 755 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
06.09.2007
Elsevier Limited |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition. However, key evidence for this role in vivo has been lacking, particularly due to gene redundancy. Here, we have obtained null mutations in the single
Drosophila neurexin gene (
dnrx).
dnrx loss of function prevents the normal proliferation of synaptic boutons at glutamatergic neuromuscular junctions, while
dnrx gain of function in neurons has the opposite effect. DNRX mostly localizes to the active zone of presynaptic terminals. Conspicuously,
dnrx null mutants display striking defects in synaptic ultrastructure, with the presence of detachments between pre- and postsynaptic membranes, abnormally long active zones, and increased number of T bars. These abnormalities result in corresponding alterations in synaptic transmission with reduced quantal content. Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments. |
---|---|
AbstractList | Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition. However, key evidence for this role in vivo has been lacking, particularly due to gene redundancy. Here, we have obtained null mutations in the singleDrosophila neurexingene (dnrx).dnrxloss of function prevents the normal proliferation of synaptic boutons at glutamatergic neuromuscular junctions, whilednrxgain of function in neurons has the opposite effect. DNRX mostly localizes to the active zone of presynaptic terminals. Conspicuously,dnrxnull mutants display striking defects in synaptic ultrastructure, with the presence of detachments between pre- and postsynaptic membranes, abnormally long active zones, and increased number of T bars. These abnormalities result in corresponding alterations in synaptic transmission with reduced quantal content. Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments. Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition. However, key evidence for this role in vivo has been lacking, particularly due to gene redundancy. Here, we have obtained null mutations in the single Drosophila neurexin gene (dnrx). dnrx loss of function prevents the normal proliferation of synaptic boutons at glutamatergic neuromuscular junctions, while dnrx gain of function in neurons has the opposite effect. DNRX mostly localizes to the active zone of presynaptic terminals. Conspicuously, dnrx null mutants display striking defects in synaptic ultrastructure, with the presence of detachments between pre- and postsynaptic membranes, abnormally long active zones, and increased number of T bars. These abnormalities result in corresponding alterations in synaptic transmission with reduced quantal content. Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments. Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition. However, key evidence for this role in vivo has been lacking, particularly due to gene redundancy. Here, we have obtained null mutations in the single Drosophila neurexin gene ( dnrx). dnrx loss of function prevents the normal proliferation of synaptic boutons at glutamatergic neuromuscular junctions, while dnrx gain of function in neurons has the opposite effect. DNRX mostly localizes to the active zone of presynaptic terminals. Conspicuously, dnrx null mutants display striking defects in synaptic ultrastructure, with the presence of detachments between pre- and postsynaptic membranes, abnormally long active zones, and increased number of T bars. These abnormalities result in corresponding alterations in synaptic transmission with reduced quantal content. Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments. Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition. However, key evidence for this role in vivo has been lacking, particularly due to gene redundancy. Here, we have obtained null mutations in the single Drosophila n eurexin gene ( dnrx ). dnrx loss of function prevents the normal proliferation of synaptic boutons at glutamatergic neuromuscular junctions, while dnrx gain of function in neurons has the opposite effect. DNRX mostly localizes to the active zone of presynaptic terminals. Conspicuously, dnrx null mutants display striking defects in synaptic ultrastructure with the presence of detachments between pre- and postsynaptic membranes, abnormally long active zones, and increased number of T-bars. These abnormalities result in corresponding alterations in synaptic transmission, which reduced quantal content. Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments. |
Author | Budnik, Vivian Ashley, James Bhat, Manzoor A. Li, Jingjun |
AuthorAffiliation | 1 Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC-Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine Chapel Hill, NC 27599-7545 2 Department of Neurobiology University of Massachusetts Medical School Worcester, MA 01605 |
AuthorAffiliation_xml | – name: 2 Department of Neurobiology University of Massachusetts Medical School Worcester, MA 01605 – name: 1 Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC-Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine Chapel Hill, NC 27599-7545 |
Author_xml | – sequence: 1 givenname: Jingjun surname: Li fullname: Li, Jingjun organization: Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC-Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7545, USA – sequence: 2 givenname: James surname: Ashley fullname: Ashley, James organization: Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA – sequence: 3 givenname: Vivian surname: Budnik fullname: Budnik, Vivian organization: Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA – sequence: 4 givenname: Manzoor A. surname: Bhat fullname: Bhat, Manzoor A. email: manzoor_bhat@med.unc.edu organization: Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC-Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7545, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17785181$$D View this record in MEDLINE/PubMed |
BookMark | eNp9UdGK1DAUDbLizq7-gUhA8Glbb9pOmr4Iw6yuwqKLri--hDS9dTJ0km6Sju4v-NVmmNFRH4RA4N5zzz3nnjNyYp1FQp4yyBkw_nKdW5y8s3kBUOcgcoDiAZkxaOqsYk1zQmYgGp7xoi5PyVkIawBWzRv2iJyyuhZzJtiM_Fj6SRs10I9uQOp6euldcOPKDIq-T_z43Via3o13I3q60NFskX5JUuhiHF0w0ThLo6M3LsRwb9UYjaaXaHcdDBf006_alXff4uqCKtsdi7de2bAxISSWx-Rhr4aATw7_Ofn85vXt8m12_eHq3XJxnWkOPGaC9QVjuhPARD8XHfBKNWLOe1Fgq8q2auueF1CpolYV1B2vWoU9YNt2omVYlOfk1Z53nNoNdhpt9GqQozcb5e-lU0b-3bFmJb-6rSygbBrGEsGLA4F3dxOGKJMDjcOgLLopSC6KtFjwBHz-D3DtJm-TOcnmUHJeV9VOT7VH6XT64LH_LYWB3EUt13IftdxFLUHIFHUae_anjePQIdujT0zH3Br0MmiDVmNnPOooO2f-v-EnUr7B0w |
CitedBy_id | crossref_primary_10_1016_j_conb_2014_02_009 crossref_primary_10_1016_j_bbr_2013_06_020 crossref_primary_10_1083_jcb_201307020 crossref_primary_10_1073_pnas_2318041121 crossref_primary_10_7554_eLife_87902 crossref_primary_10_1016_j_neuron_2015_05_015 crossref_primary_10_3389_fnins_2019_00027 crossref_primary_10_1038_s41398_023_02668_z crossref_primary_10_1074_jbc_M117_810242 crossref_primary_10_1007_s12264_017_0166_6 crossref_primary_10_1083_jcb_200812150 crossref_primary_10_1097_YPG_0000000000000211 crossref_primary_10_1111_1744_7917_12312 crossref_primary_10_1016_j_neures_2009_04_009 crossref_primary_10_1016_j_neuron_2012_11_012 crossref_primary_10_1371_journal_pgen_1005810 crossref_primary_10_3390_cells10081924 crossref_primary_10_1242_dev_202517 crossref_primary_10_1242_dev_109538 crossref_primary_10_1016_j_bbamem_2020_183211 crossref_primary_10_7554_eLife_30457 crossref_primary_10_1074_jbc_M703957200 crossref_primary_10_3389_fnana_2018_00081 crossref_primary_10_1016_j_mcn_2009_11_009 crossref_primary_10_1038_srep38246 crossref_primary_10_1016_j_cell_2011_11_028 crossref_primary_10_1016_j_ajhg_2009_10_004 crossref_primary_10_1016_j_neuron_2009_11_002 crossref_primary_10_1186_s13064_020_00147_5 crossref_primary_10_1523_JNEUROSCI_2002_19_2020 crossref_primary_10_1523_ENEURO_0461_22_2023 crossref_primary_10_1523_JNEUROSCI_1685_12_2012 crossref_primary_10_1146_annurev_neuro_051508_135302 crossref_primary_10_1371_journal_pone_0003542 crossref_primary_10_1007_s10158_014_0173_5 crossref_primary_10_1111_gbb_12046 crossref_primary_10_1016_j_neuropharm_2011_01_024 crossref_primary_10_1016_j_devcel_2017_03_004 crossref_primary_10_1016_j_cell_2010_04_035 crossref_primary_10_1016_j_cub_2021_01_093 crossref_primary_10_1038_mp_2010_35 crossref_primary_10_1534_genetics_117_300538 crossref_primary_10_1371_journal_pone_0075902 crossref_primary_10_1038_s41598_018_35618_7 crossref_primary_10_1093_hmg_ddac115 crossref_primary_10_1016_j_neuron_2018_09_007 crossref_primary_10_7554_eLife_31659 crossref_primary_10_1016_j_gde_2011_01_002 crossref_primary_10_1007_s11427_012_4273_3 crossref_primary_10_1371_journal_pone_0067161 crossref_primary_10_1002_jnr_21849 crossref_primary_10_1016_j_neuron_2010_05_020 crossref_primary_10_3389_fncel_2023_1257347 crossref_primary_10_1111_cge_13537 crossref_primary_10_1161_ATVBAHA_111_243006 crossref_primary_10_1016_j_celrep_2016_03_034 crossref_primary_10_7554_eLife_35692 crossref_primary_10_1080_00048670802203467 crossref_primary_10_1371_journal_pgen_1010016 crossref_primary_10_1523_JNEUROSCI_6075_11_2013 crossref_primary_10_1016_j_conb_2008_07_014 crossref_primary_10_1016_j_mcn_2012_08_010 crossref_primary_10_1038_nature10923 crossref_primary_10_3389_fnana_2020_00019 crossref_primary_10_1093_hmg_ddaa260 crossref_primary_10_1016_j_smrv_2022_101595 crossref_primary_10_1523_JNEUROSCI_0983_10_2010 crossref_primary_10_1186_s13041_023_01073_3 crossref_primary_10_1074_jbc_M114_574897 crossref_primary_10_1038_nn_2991 crossref_primary_10_1242_dev_202558 crossref_primary_10_1016_j_neuron_2010_04_008 crossref_primary_10_1016_j_mcn_2014_07_005 crossref_primary_10_1016_j_celrep_2019_07_004 crossref_primary_10_1371_journal_pgen_1004998 crossref_primary_10_1371_journal_pone_0036339 crossref_primary_10_1016_j_celrep_2021_108753 crossref_primary_10_1016_j_neuron_2013_12_021 crossref_primary_10_1016_j_mcn_2016_11_004 crossref_primary_10_1111_ejn_13023 crossref_primary_10_1242_jcs_186627 crossref_primary_10_3389_fncel_2015_00204 crossref_primary_10_1074_jbc_M117_794040 crossref_primary_10_1261_rna_045849_114 crossref_primary_10_1016_j_cell_2018_07_002 crossref_primary_10_3389_fncel_2019_00192 crossref_primary_10_1016_j_pneurobio_2011_08_003 crossref_primary_10_1038_s41537_017_0040_6 crossref_primary_10_4161_rna_21409 crossref_primary_10_3389_fphys_2020_611982 crossref_primary_10_1038_ncomms9362 crossref_primary_10_1534_genetics_115_176529 crossref_primary_10_1038_s41586_021_03441_2 crossref_primary_10_1038_s41583_020_00415_7 crossref_primary_10_7554_eLife_27347 crossref_primary_10_1074_jbc_M115_644583 crossref_primary_10_1007_s12035_011_8213_1 crossref_primary_10_15252_embj_2019103208 crossref_primary_10_1038_s41467_019_13165_7 crossref_primary_10_1007_s11427_015_4946_9 crossref_primary_10_1038_nn_3183 crossref_primary_10_1111_dgd_12916 crossref_primary_10_1083_jcb_200908055 crossref_primary_10_1007_s00018_011_0664_z crossref_primary_10_1093_hmg_ddt567 crossref_primary_10_1371_journal_pone_0011115 crossref_primary_10_1093_hmg_ddu094 crossref_primary_10_7554_eLife_03726 crossref_primary_10_1002_dneu_22720 crossref_primary_10_1016_j_jpsychires_2011_10_015 crossref_primary_10_7554_eLife_13881 crossref_primary_10_1523_JNEUROSCI_5294_07_2008 crossref_primary_10_1523_JNEUROSCI_3854_10_2011 crossref_primary_10_1016_j_neuron_2017_04_011 crossref_primary_10_1016_j_neuron_2020_10_006 |
Cites_doi | 10.1016/j.neuron.2004.07.001 10.1073/pnas.0611003104 10.1126/science.1126308 10.1523/JNEUROSCI.0497-05.2005 10.1016/j.cell.2004.11.035 10.1093/bib/5.2.150 10.1152/jn.00647.2003 10.1083/jcb.200105003 10.2741/1978 10.1016/j.neuron.2004.06.029 10.1016/S0896-6273(00)81170-8 10.1016/S0168-9525(97)01324-3 10.1016/S0896-6273(00)80196-8 10.1016/S0896-6273(00)80624-8 10.1126/science.1107470 10.1016/S0896-6273(00)80415-8 10.1146/annurev.neuro.26.043002.094940 10.1016/S0896-6273(00)81169-1 10.1523/JNEUROSCI.19-18-07793.1999 10.1523/JNEUROSCI.3553-03.2004 10.1006/geno.2002.6780 10.1006/geno.2002.6734 10.1021/bi0614131 10.1016/S0896-6273(00)81135-6 10.1523/JNEUROSCI.1575-03.2004 10.1523/JNEUROSCI.16-08-02488.1996 10.1016/S0960-9822(00)80087-1 10.1242/dev.127.19.4157 10.1038/nature01755 10.1073/pnas.96.3.1100 10.1073/pnas.0406157101 10.1126/science.287.5461.2185 10.1016/S0896-6273(01)00294-X 10.1016/S0092-8674(00)81800-0 10.1016/S0896-6273(04)00016-9 10.1242/dev.00199 10.1038/sj.emboj.7601503 10.1073/pnas.0308626100 10.1016/S0092-8674(00)81920-0 10.1126/science.1621094 10.1073/pnas.252774899 10.1074/jbc.M413812200 10.1242/dev.118.4.1077 10.1016/0896-6273(94)90022-1 10.1016/j.semcdb.2005.11.010 10.1126/science.1077198 10.1016/j.neuron.2005.08.026 10.1016/0896-6273(93)90320-Q 10.1242/dev.01372 10.1523/JNEUROSCI.1253-05.2006 10.1038/ng1314 10.1016/0896-6273(94)90249-6 10.1016/S0166-2236(98)01267-3 10.1016/S0074-7742(06)75011-5 10.1016/j.neuron.2006.02.008 10.1016/S0896-6273(00)81049-1 10.1523/JNEUROSCI.16-12-03877.1996 10.1073/pnas.0405939101 10.1016/S0955-0674(03)00107-8 10.1523/JNEUROSCI.0032-07.2007 10.1016/j.neuron.2006.06.005 10.1016/0092-8674(94)90556-8 10.1523/JNEUROSCI.5383-05.2006 10.1126/science.277.5331.1511 10.1016/j.febslet.2007.04.068 10.1016/0092-8674(95)90396-8 10.1128/MCB.16.5.1896 10.1523/JNEUROSCI.16-24-07868.1996 10.1016/j.neuropharm.2004.06.023 10.1016/S0896-6273(02)01065-6 10.1074/jbc.C000656200 10.1523/JNEUROSCI.1144-05.2005 10.1073/pnas.0502038102 10.1016/S0092-8674(00)80877-6 10.1038/nn1074 10.1016/S0896-6273(01)00500-1 |
ContentType | Journal Article |
Copyright | 2007 Elsevier Inc. Copyright Elsevier Limited Sep 6, 2007 |
Copyright_xml | – notice: 2007 Elsevier Inc. – notice: Copyright Elsevier Limited Sep 6, 2007 |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7QR 7TK 8FD FR3 K9. NAPCQ P64 RC3 7X8 5PM |
DOI | 10.1016/j.neuron.2007.08.002 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Neurosciences Abstracts Technology Research Database Engineering Research Database ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Nursing & Allied Health Premium Genetics Abstracts Technology Research Database ProQuest Health & Medical Complete (Alumni) Chemoreception Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitleList | Nursing & Allied Health Premium MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Biology |
EISSN | 1097-4199 |
EndPage | 755 |
ExternalDocumentID | 3234784231 10_1016_j_neuron_2007_08_002 17785181 S0896627307006137 |
Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: NIMH NIH HHS grantid: R01 MH070000 – fundername: NINDS NIH HHS grantid: NS050356 – fundername: NIMH NIH HHS grantid: R37 MH070000 – fundername: NINDS NIH HHS grantid: R01 NS030072 – fundername: NIGMS NIH HHS grantid: R01 GM063074 – fundername: NIGMS NIH HHS grantid: GM63074 – fundername: NINDS NIH HHS grantid: R01 NS050356 – fundername: NINDS NIH HHS grantid: R01 NS050356-02 – fundername: NIMH NIH HHS grantid: MH070000 – fundername: NIGMS NIH HHS grantid: R01 GM063074-06A1 |
GroupedDBID | --- --K -DZ -~X .55 .GJ 0R~ 123 1RT 1~5 26- 29N 2WC 3O- 3V. 4.4 457 4G. 53G 5RE 5VS 62- 6I. 7-5 7RV 7X7 8C1 8FE 8FH AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKRW AAKUH AALRI AAQFI AAQXK AAUCE AAVLU AAXJY AAXUO ABJNI ABMAC ABMWF ABVKL ACGFO ACGFS ACIWK ACNCT ACPRK ADBBV ADEZE ADFRT ADJPV ADMUD AEFWE AENEX AEXQZ AFKRA AFTJW AGHFR AGKMS AHHHB AHMBA AHPSJ AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ AQUVI ASPBG AVWKF AZFZN BAWUL BBNVY BENPR BHPHI BKEYQ BKNYI BPHCQ BVXVI CS3 DIK DU5 E3Z EBS EJD F5P FCP FDB FEDTE FGOYB FIRID G-2 HCIFZ HVGLF HZ~ IAO IHE IHR INH IXB J1W JIG K-O KQ8 L7B LK8 LX5 M0R M0T M2M M2O M3Z M41 M7P MVM N9A NCXOZ O-L O9- OK1 OZT P2P P6G PQQKQ PROAC R2- RCE RIG ROL RPZ SCP SDP SES SSZ TR2 WOW WQ6 X7M ZA5 ZGI ZKB 0SF AAMRU ADVLN AKAPO AKRWK CGR CUY CVF ECM EIF NPM AAYXX ACRPL CITATION ITC 7QP 7QR 7TK 8FD FR3 K9. NAPCQ P64 RC3 7X8 5PM |
ID | FETCH-LOGICAL-c606t-81f211cd8018f58d064a9856f82eba3b4b7f6204a27a407d64baef0ebbd8b1e23 |
IEDL.DBID | ABVKL |
ISSN | 0896-6273 |
IngestDate | Tue Sep 17 21:27:14 EDT 2024 Fri Oct 25 23:22:44 EDT 2024 Thu Oct 10 16:40:40 EDT 2024 Fri Dec 06 03:31:11 EST 2024 Sat Sep 28 07:53:22 EDT 2024 Fri Feb 23 02:28:26 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 5 |
Keywords | CELLBIO DEVBIO MOLNEURO |
Language | English |
License | http://www.elsevier.com/open-access/userlicense/1.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c606t-81f211cd8018f58d064a9856f82eba3b4b7f6204a27a407d64baef0ebbd8b1e23 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Both VB and MB share senior authorship equally |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0896627307006137 |
PMID | 17785181 |
PQID | 1503667442 |
PQPubID | 2031076 |
PageCount | 15 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2039911 proquest_miscellaneous_68240786 proquest_journals_1503667442 crossref_primary_10_1016_j_neuron_2007_08_002 pubmed_primary_17785181 elsevier_sciencedirect_doi_10_1016_j_neuron_2007_08_002 |
PublicationCentury | 2000 |
PublicationDate | 2007-09-06 |
PublicationDateYYYYMMDD | 2007-09-06 |
PublicationDate_xml | – month: 09 year: 2007 text: 2007-09-06 day: 06 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Cambridge |
PublicationTitle | Neuron (Cambridge, Mass.) |
PublicationTitleAlternate | Neuron |
PublicationYear | 2007 |
Publisher | Elsevier Inc Elsevier Limited |
Publisher_xml | – name: Elsevier Inc – name: Elsevier Limited |
References | Bellen, Budnik (bib7) 2000 Roos, Hummel, Ng, Klambt, Davis (bib59) 2000; 26 Littleton, Ganetzky (bib42) 2000; 26 Griffith, Budnik (bib26) 2006; 75 Wagh, Rasse, Asan, Hofbauer, Schwenkert, Durrbeck, Buchner, Dabauvalle, Schmidt, Qin (bib74) 2006; 49 Murthy, Schikorski, Stevens, Zhu (bib50) 2001; 32 Chih, Engelman, Scheiffele (bib13) 2005; 307 Graf, Zhang, Jin, Linhoff, Craig (bib24) 2004; 119 Ushkaryov, Petrenko, Geppert, Sudhof (bib73) 1992; 257 Scheiffele (bib61) 2003; 26 Thibault, Singer, Miyazaki, Milash, Dompe, Singh, Buchholz, Demsky, Fawcett, Francis-Lang (bib71) 2004; 36 Ashley, Packard, Ataman, Budnik (bib3) 2005; 25 Missler, Sudhof (bib48) 1998; 14 Nam, Chen (bib51) 2005; 102 Kittel, Wichmann, Rasse, Fouquet, Schmidt, Schmid, Wagh, Pawlu, Kellner, Willig (bib36) 2006; 312 Sugita, Saito, Tang, Satz, Campbell, Sudhof (bib68) 2001; 154 Petersen, Fetter, Noordermeer, Goodman, DiAntonio (bib54) 1997; 19 Adams, Celniker, Holt, Evans, Gocayne, Amanatides, Scherer, Li, Hoskins, Galle (bib1) 2000; 287 Poliak, Gollan, Martinez, Custer, Einheber, Salzer, Trimmer, Shrager, Peles (bib55) 1999; 24 Kumar, Tamura, Nei (bib38) 2004; 5 Banerjee, Pillai, Paik, Li, Bhat (bib5) 2006; 26 Shcherbata, Yatsenko, Patterson, Sood, Nudel, Yaffe, Baker, Ruohola-Baker (bib63) 2007; 26 Zeng, Sun, Liu, Chen, Wei, Xie (bib77) 2007; 581 Koh, Verstreken, Bellen (bib37) 2004; 43 Smith, Wang, Peixoto, Neumann, Hall, Hall (bib64) 1996; 16 Baumgartner, Littleton, Broadie, Bhat, Harbecke, Lengyel, Chiquet-Ehrismann, Prokop, Bellen (bib6) 1996; 87 Chih, Gollan, Scheiffele (bib14) 2006; 51 Hummel, Krukkert, Roos, Davis, Klambt (bib31) 2000; 26 Littleton, Bellen, Perin (bib43) 1993; 118 Meyer, Varoqueaux, Neeb, Oschlies, Brose (bib47) 2004; 47 Hata, Butz, Sudhof (bib29) 1996; 16 Graf, Kang, Hauner, Craig (bib25) 2006; 26 Bellen, Lu, Beckstead, Bhat (bib8) 1998; 21 Marie, Sweeney, Poskanzer, Roos, Kelly, Davis (bib44) 2004; 43 Bhat, Rios, Lu, Garcia-Fresco, Ching, St Martin, Li, Einheber, Chesler, Rosenbluth (bib9) 2001; 30 Budnik, Koh, Guan, Hartmann, Hough, Woods, Gorczyca (bib12) 1996; 17 Connolly, Tully (bib16) 1998 Sone, Suzuki, Hoshino, Hou, Kuromi, Fukata, Kuroda, Kaibuchi, Nabeshima, Hama (bib65) 2000; 127 Irie, Hata, Takeuchi, Ichtchenko, Toyoda, Hirao, Takai, Rosahl, Sudhof (bib33) 1997; 277 Biederer, Sudhof (bib10) 2000; 275 Missler, Zhang, Rohlmann, Kattenstroth, Hammer, Gottmann, Sudhof (bib49) 2003; 423 Geppert, Goda, Hammer, Li, Rosahl, Stevens, Sudhof (bib22) 1994; 79 Coyle, Koh, Lee, Slind, Fergestad, Littleton, Ganetzky (bib17) 2004; 41 McVey, Larocque, Adams, Sekelsky (bib46) 2004; 101 Rowen, Young, Birditt, Kaur, Madan, Philipps, Qin, Minx, Wilson, Hood, Graveley (bib60) 2002; 79 Gerrow, El-Husseini (bib23) 2006; 11 Levinson, Chery, Huang, Wong, Gerrow, Kang, Prange, Wang, El-Husseini (bib40) 2005; 280 Prange, Wong, Gerrow, Wang, El-Husseini (bib56) 2004; 101 O'Brien, Kamboj, Ehlers, Rosen, Fischbach, Huganir (bib52) 1998; 21 Ho, Morishita, Hammer, Malenka, Sudhof (bib30) 2003; 100 Roos, Kelly (bib58) 1999; 9 Zhang, Rohlmann, Sargsyan, Aramuni, Hammer, Sudhof, Missler (bib78) 2005; 25 Fu, Washbourne, Ortinski, Vicini (bib21) 2003; 90 Faivre-Sarrailh, Banerjee, Li, Hortsch, Laval, Bhat (bib20) 2004; 131 Harden, Lee, Loh, Ong, Tan, Leung, Manser, Lim (bib27) 1996; 16 Comoletti, Flynn, Boucard, Demeler, Schirf, Shi, Jennings, Newlin, Sudhof, Taylor (bib15) 2006; 45 Kawasaki, Zou, Xu, Ordway (bib35) 2004; 24 Taniguchi, Gollan, Scholl, Mahadomrongkul, Dobler, Limthong, Peck, Aoki, Scheiffele (bib70) 2007; 27 Boucard, Chubykin, Comoletti, Taylor, Sudhof (bib11) 2005; 48 Adams, McVey, Sekelsky (bib2) 2003; 299 Lahey, Gorczyca, Jia, Budnik (bib39) 1994; 13 Marrus, Portman, Allen, Moffat, DiAntonio (bib45) 2004; 24 Stewart, Schuster, Goodman, Atwood (bib67) 1996; 16 Peles, Joho, Plowman, Schlessinger (bib53) 1997; 88 Scheiffele, Fan, Choih, Fetter, Serafini (bib62) 2000; 101 Song, Ichtchenko, Sudhof, Brose (bib66) 1999; 96 Atasoy, Schoch, Ho, Nadasy, Liu, Zhang, Mukherjee, Nosyreva, Fernandez-Chacon, Missler (bib4) 2007; 104 Prokop, Meinertzhagen (bib57) 2006; 17 Yoshihara, Littleton (bib76) 2002; 36 Deng, Schneider, Frock, Castillejo-Lopez, Gaman, Baumgartner, Ruohola-Baker (bib19) 2003; 130 Kattenstroth, Tantalaki, Sudhof, Gottmann, Missler (bib34) 2004; 101 Yamagata, Sanes, Weiner (bib75) 2003; 15 Hata, Davletov, Petrenko, Jahn, Sudhof (bib28) 1993; 10 Lin, Goodman (bib41) 1994; 13 Torroja, Packard, Gorczyca, White, Budnik (bib72) 1999; 19 Dean, Scholl, Choih, DeMaria, Berger, Isacoff, Scheiffele (bib18) 2003; 6 Ichtchenko, Hata, Nguyen, Ullrich, Missler, Moomaw, Sudhof (bib32) 1995; 81 Tabuchi, Sudhof (bib69) 2002; 79 8656281 - J Neurosci. 1996 Jun 15;16(12):3877-86 8628256 - Mol Cell Biol. 1996 May;16(5):1896-908 17215867 - EMBO J. 2007 Jan 24;26(2):481-93 12441301 - Development. 2003 Jan;130(1):173-84 15459097 - Development. 2004 Oct;131(20):4931-42 16624946 - J Neurosci. 2006 Apr 19;26(16):4256-65 16720322 - Front Biosci. 2006;11:2400-19 10624965 - Neuron. 1999 Dec;24(4):1037-47 12522255 - Science. 2003 Jan 10;299(5604):265-7 12547917 - Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1409-14 15260956 - Neuron. 2004 Jul 22;43(2):193-205 7736595 - Cell. 1995 May 5;81(3):435-43 17360903 - J Neurosci. 2007 Mar 14;27(11):2815-24 8893021 - Neuron. 1996 Oct;17(4):627-40 7954835 - Cell. 1994 Nov 18;79(4):717-27 11395000 - Neuron. 2001 May;30(2):369-83 16543132 - Neuron. 2006 Mar 16;49(6):833-44 16242404 - Neuron. 2005 Oct 20;48(2):229-36 1621094 - Science. 1992 Jul 3;257(5066):50-6 8439414 - Neuron. 1993 Feb;10(2):307-15 8786425 - J Neurosci. 1996 Apr 15;16(8):2488-94 14983056 - Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2607-12 16614170 - Science. 2006 May 19;312(5776):1051-4 14960613 - J Neurosci. 2004 Feb 11;24(6):1406-15 9786343 - Trends Neurosci. 1998 Oct;21(10):444-9 8978610 - Cell. 1996 Dec 13;87(6):1059-68 10892652 - Cell. 2000 Jun 9;101(6):657-69 17287346 - Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2525-30 17042500 - Biochemistry. 2006 Oct 24;45(42):12816-27 12036300 - Genomics. 2002 Jun;79(6):849-59 12827191 - Nature. 2003 Jun 26;423(6943):939-48 9927700 - Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1100-5 15358863 - Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13915-20 16846852 - Neuron. 2006 Jul 20;51(2):171-8 7917288 - Neuron. 1994 Sep;13(3):507-23 15681343 - Science. 2005 Feb 25;307(5713):1324-8 15837930 - Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6137-42 16384719 - Semin Cell Dev Biol. 2006 Feb;17(1):20-30 10839355 - Neuron. 2000 May;26(2):357-70 9118217 - Cell. 1997 Mar 21;88(6):745-6 15858059 - J Neurosci. 2005 Apr 27;25(17):4330-42 8269841 - Development. 1993 Aug;118(4):1077-88 15723836 - J Biol Chem. 2005 Apr 29;280(17):17312-9 10839356 - Neuron. 2000 May;26(2):371-82 8987815 - J Neurosci. 1996 Dec 15;16(24):7868-79 12930820 - J Neurophysiol. 2003 Dec;90(6):3950-7 9448462 - Trends Genet. 1998 Jan;14(1):20-6 10976048 - Development. 2000 Oct;127(19):4157-68 11719207 - Neuron. 2001 Nov 20;32(4):673-82 12626697 - Annu Rev Neurosci. 2003;26:485-508 15620359 - Cell. 2004 Dec 29;119(7):1013-26 14980202 - Neuron. 2004 Feb 19;41(4):521-34 14981521 - Nat Genet. 2004 Mar;36(3):283-7 15976083 - J Neurosci. 2005 Jun 22;25(25):5943-55 9427247 - Neuron. 1997 Dec;19(6):1237-48 9278515 - Science. 1997 Sep 5;277(5331):1511-5 16554482 - J Neurosci. 2006 Mar 22;26(12):3319-29 10731132 - Science. 2000 Mar 24;287(5461):2185-95 14715960 - J Neurosci. 2004 Jan 7;24(1):282-5 15458844 - Neuropharmacology. 2004 Oct;47(5):724-33 10479682 - J Neurosci. 1999 Sep 15;19(18):7793-803 11036064 - J Biol Chem. 2000 Dec 22;275(51):39803-6 17498701 - FEBS Lett. 2007 May 29;581(13):2509-16 11470830 - J Cell Biol. 2001 Jul 23;154(2):435-45 12467593 - Neuron. 2002 Dec 5;36(5):897-908 14519398 - Curr Opin Cell Biol. 2003 Oct;15(5):621-32 17137931 - Int Rev Neurobiol. 2006;75:237-65 12796785 - Nat Neurosci. 2003 Jul;6(7):708-16 9856462 - Neuron. 1998 Nov;21(5):1067-78 11944992 - Genomics. 2002 Apr;79(4):587-97 10607569 - Curr Biol. 1999 Dec 2;9(23):1411-4 10798390 - Neuron. 2000 Apr;26(1):35-43 15501916 - Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15694-9 15260957 - Neuron. 2004 Jul 22;43(2):207-19 7946331 - Neuron. 1994 Oct;13(4):823-35 Ichtchenko (10.1016/j.neuron.2007.08.002_bib32) 1995; 81 Ashley (10.1016/j.neuron.2007.08.002_bib3) 2005; 25 Kattenstroth (10.1016/j.neuron.2007.08.002_bib34) 2004; 101 Connolly (10.1016/j.neuron.2007.08.002_bib16) 1998 Wagh (10.1016/j.neuron.2007.08.002_bib74) 2006; 49 Gerrow (10.1016/j.neuron.2007.08.002_bib23) 2006; 11 Thibault (10.1016/j.neuron.2007.08.002_bib71) 2004; 36 Biederer (10.1016/j.neuron.2007.08.002_bib10) 2000; 275 Marrus (10.1016/j.neuron.2007.08.002_bib45) 2004; 24 Missler (10.1016/j.neuron.2007.08.002_bib49) 2003; 423 Coyle (10.1016/j.neuron.2007.08.002_bib17) 2004; 41 Hata (10.1016/j.neuron.2007.08.002_bib28) 1993; 10 Meyer (10.1016/j.neuron.2007.08.002_bib47) 2004; 47 Marie (10.1016/j.neuron.2007.08.002_bib44) 2004; 43 Shcherbata (10.1016/j.neuron.2007.08.002_bib63) 2007; 26 Koh (10.1016/j.neuron.2007.08.002_bib37) 2004; 43 Nam (10.1016/j.neuron.2007.08.002_bib51) 2005; 102 Kawasaki (10.1016/j.neuron.2007.08.002_bib35) 2004; 24 Bellen (10.1016/j.neuron.2007.08.002_bib8) 1998; 21 Roos (10.1016/j.neuron.2007.08.002_bib59) 2000; 26 Littleton (10.1016/j.neuron.2007.08.002_bib42) 2000; 26 Prange (10.1016/j.neuron.2007.08.002_bib56) 2004; 101 Peles (10.1016/j.neuron.2007.08.002_bib53) 1997; 88 O'Brien (10.1016/j.neuron.2007.08.002_bib52) 1998; 21 Missler (10.1016/j.neuron.2007.08.002_bib48) 1998; 14 Levinson (10.1016/j.neuron.2007.08.002_bib40) 2005; 280 Fu (10.1016/j.neuron.2007.08.002_bib21) 2003; 90 Lin (10.1016/j.neuron.2007.08.002_bib41) 1994; 13 Scheiffele (10.1016/j.neuron.2007.08.002_bib61) 2003; 26 Deng (10.1016/j.neuron.2007.08.002_bib19) 2003; 130 Prokop (10.1016/j.neuron.2007.08.002_bib57) 2006; 17 Bhat (10.1016/j.neuron.2007.08.002_bib9) 2001; 30 Tabuchi (10.1016/j.neuron.2007.08.002_bib69) 2002; 79 Boucard (10.1016/j.neuron.2007.08.002_bib11) 2005; 48 Yamagata (10.1016/j.neuron.2007.08.002_bib75) 2003; 15 Kumar (10.1016/j.neuron.2007.08.002_bib38) 2004; 5 Zeng (10.1016/j.neuron.2007.08.002_bib77) 2007; 581 Petersen (10.1016/j.neuron.2007.08.002_bib54) 1997; 19 Ho (10.1016/j.neuron.2007.08.002_bib30) 2003; 100 Chih (10.1016/j.neuron.2007.08.002_bib14) 2006; 51 Scheiffele (10.1016/j.neuron.2007.08.002_bib62) 2000; 101 Rowen (10.1016/j.neuron.2007.08.002_bib60) 2002; 79 Atasoy (10.1016/j.neuron.2007.08.002_bib4) 2007; 104 Chih (10.1016/j.neuron.2007.08.002_bib13) 2005; 307 Harden (10.1016/j.neuron.2007.08.002_bib27) 1996; 16 Adams (10.1016/j.neuron.2007.08.002_bib2) 2003; 299 Graf (10.1016/j.neuron.2007.08.002_bib25) 2006; 26 Ushkaryov (10.1016/j.neuron.2007.08.002_bib73) 1992; 257 Comoletti (10.1016/j.neuron.2007.08.002_bib15) 2006; 45 Stewart (10.1016/j.neuron.2007.08.002_bib67) 1996; 16 Torroja (10.1016/j.neuron.2007.08.002_bib72) 1999; 19 Hummel (10.1016/j.neuron.2007.08.002_bib31) 2000; 26 Taniguchi (10.1016/j.neuron.2007.08.002_bib70) 2007; 27 Banerjee (10.1016/j.neuron.2007.08.002_bib5) 2006; 26 Bellen (10.1016/j.neuron.2007.08.002_bib7) 2000 Smith (10.1016/j.neuron.2007.08.002_bib64) 1996; 16 Kittel (10.1016/j.neuron.2007.08.002_bib36) 2006; 312 Dean (10.1016/j.neuron.2007.08.002_bib18) 2003; 6 Adams (10.1016/j.neuron.2007.08.002_bib1) 2000; 287 Roos (10.1016/j.neuron.2007.08.002_bib58) 1999; 9 Zhang (10.1016/j.neuron.2007.08.002_bib78) 2005; 25 McVey (10.1016/j.neuron.2007.08.002_bib46) 2004; 101 Song (10.1016/j.neuron.2007.08.002_bib66) 1999; 96 Lahey (10.1016/j.neuron.2007.08.002_bib39) 1994; 13 Faivre-Sarrailh (10.1016/j.neuron.2007.08.002_bib20) 2004; 131 Yoshihara (10.1016/j.neuron.2007.08.002_bib76) 2002; 36 Geppert (10.1016/j.neuron.2007.08.002_bib22) 1994; 79 Griffith (10.1016/j.neuron.2007.08.002_bib26) 2006; 75 Littleton (10.1016/j.neuron.2007.08.002_bib43) 1993; 118 Sone (10.1016/j.neuron.2007.08.002_bib65) 2000; 127 Hata (10.1016/j.neuron.2007.08.002_bib29) 1996; 16 Baumgartner (10.1016/j.neuron.2007.08.002_bib6) 1996; 87 Irie (10.1016/j.neuron.2007.08.002_bib33) 1997; 277 Graf (10.1016/j.neuron.2007.08.002_bib24) 2004; 119 Sugita (10.1016/j.neuron.2007.08.002_bib68) 2001; 154 Budnik (10.1016/j.neuron.2007.08.002_bib12) 1996; 17 Poliak (10.1016/j.neuron.2007.08.002_bib55) 1999; 24 Murthy (10.1016/j.neuron.2007.08.002_bib50) 2001; 32 |
References_xml | – volume: 25 start-page: 4330 year: 2005 end-page: 4342 ident: bib78 article-title: Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels publication-title: J. Neurosci. contributor: fullname: Missler – volume: 5 start-page: 150 year: 2004 end-page: 163 ident: bib38 article-title: MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment publication-title: Brief. Bioinform. contributor: fullname: Nei – volume: 131 start-page: 4931 year: 2004 end-page: 4942 ident: bib20 article-title: Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function publication-title: Development contributor: fullname: Bhat – volume: 101 start-page: 15694 year: 2004 end-page: 15699 ident: bib46 article-title: Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Sekelsky – volume: 49 start-page: 833 year: 2006 end-page: 844 ident: bib74 article-title: Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila publication-title: Neuron contributor: fullname: Qin – volume: 19 start-page: 7793 year: 1999 end-page: 7803 ident: bib72 article-title: The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction publication-title: J. Neurosci. contributor: fullname: Budnik – volume: 21 start-page: 444 year: 1998 end-page: 449 ident: bib8 article-title: Neurexin IV, caspr and paranodin–novel members of the neurexin family: encounters of axons and glia publication-title: Trends Neurosci. contributor: fullname: Bhat – volume: 48 start-page: 229 year: 2005 end-page: 236 ident: bib11 article-title: A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins publication-title: Neuron contributor: fullname: Sudhof – volume: 130 start-page: 173 year: 2003 end-page: 184 ident: bib19 article-title: Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila publication-title: Development contributor: fullname: Ruohola-Baker – volume: 101 start-page: 657 year: 2000 end-page: 669 ident: bib62 article-title: Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons publication-title: Cell contributor: fullname: Serafini – volume: 127 start-page: 4157 year: 2000 end-page: 4168 ident: bib65 article-title: Synaptic development is controlled in the periactive zones of Drosophila synapses publication-title: Development contributor: fullname: Hama – volume: 36 start-page: 283 year: 2004 end-page: 287 ident: bib71 article-title: A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac publication-title: Nat. Genet. contributor: fullname: Francis-Lang – volume: 13 start-page: 823 year: 1994 end-page: 835 ident: bib39 article-title: The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure publication-title: Neuron contributor: fullname: Budnik – volume: 81 start-page: 435 year: 1995 end-page: 443 ident: bib32 article-title: Neuroligin 1: a splice site-specific ligand for beta-neurexins publication-title: Cell contributor: fullname: Sudhof – volume: 26 start-page: 35 year: 2000 end-page: 43 ident: bib42 article-title: Ion channels and synaptic organization: analysis of the Drosophila genome publication-title: Neuron contributor: fullname: Ganetzky – volume: 423 start-page: 939 year: 2003 end-page: 948 ident: bib49 article-title: Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis publication-title: Nature contributor: fullname: Sudhof – volume: 27 start-page: 2815 year: 2007 end-page: 2824 ident: bib70 article-title: Silencing of neuroligin function by postsynaptic neurexins publication-title: J. Neurosci. contributor: fullname: Scheiffele – volume: 104 start-page: 2525 year: 2007 end-page: 2530 ident: bib4 article-title: Deletion of CASK in mice is lethal and impairs synaptic function publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Missler – volume: 10 start-page: 307 year: 1993 end-page: 315 ident: bib28 article-title: Interaction of synaptotagmin with the cytoplasmic domains of neurexins publication-title: Neuron contributor: fullname: Sudhof – volume: 19 start-page: 1237 year: 1997 end-page: 1248 ident: bib54 article-title: Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release publication-title: Neuron contributor: fullname: DiAntonio – volume: 51 start-page: 171 year: 2006 end-page: 178 ident: bib14 article-title: Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex publication-title: Neuron contributor: fullname: Scheiffele – volume: 96 start-page: 1100 year: 1999 end-page: 1105 ident: bib66 article-title: Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Brose – volume: 16 start-page: 7868 year: 1996 end-page: 7879 ident: bib64 article-title: A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects publication-title: J. Neurosci. contributor: fullname: Hall – volume: 25 start-page: 5943 year: 2005 end-page: 5955 ident: bib3 article-title: Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint publication-title: J. Neurosci. contributor: fullname: Budnik – volume: 312 start-page: 1051 year: 2006 end-page: 1054 ident: bib36 article-title: Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release publication-title: Science contributor: fullname: Willig – volume: 79 start-page: 587 year: 2002 end-page: 597 ident: bib60 article-title: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity publication-title: Genomics contributor: fullname: Graveley – volume: 26 start-page: 485 year: 2003 end-page: 508 ident: bib61 article-title: Cell-cell signaling during synapse formation in the CNS publication-title: Annu. Rev. Neurosci. contributor: fullname: Scheiffele – volume: 26 start-page: 481 year: 2007 end-page: 493 ident: bib63 article-title: Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy publication-title: EMBO J. contributor: fullname: Ruohola-Baker – volume: 26 start-page: 371 year: 2000 end-page: 382 ident: bib59 article-title: Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth publication-title: Neuron contributor: fullname: Davis – volume: 47 start-page: 724 year: 2004 end-page: 733 ident: bib47 article-title: The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin publication-title: Neuropharmacology contributor: fullname: Brose – volume: 277 start-page: 1511 year: 1997 end-page: 1515 ident: bib33 article-title: Binding of neuroligins to PSD-95 publication-title: Science contributor: fullname: Sudhof – volume: 280 start-page: 17312 year: 2005 end-page: 17319 ident: bib40 article-title: Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity publication-title: J. Biol. Chem. contributor: fullname: El-Husseini – volume: 6 start-page: 708 year: 2003 end-page: 716 ident: bib18 article-title: Neurexin mediates the assembly of presynaptic terminals publication-title: Nat. Neurosci. contributor: fullname: Scheiffele – volume: 26 start-page: 3319 year: 2006 end-page: 3329 ident: bib5 article-title: Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila publication-title: J. Neurosci. contributor: fullname: Bhat – volume: 45 start-page: 12816 year: 2006 end-page: 12827 ident: bib15 article-title: Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins publication-title: Biochemistry contributor: fullname: Taylor – volume: 17 start-page: 627 year: 1996 end-page: 640 ident: bib12 article-title: Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg publication-title: Neuron contributor: fullname: Gorczyca – volume: 36 start-page: 897 year: 2002 end-page: 908 ident: bib76 article-title: Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release publication-title: Neuron contributor: fullname: Littleton – volume: 24 start-page: 282 year: 2004 end-page: 285 ident: bib35 article-title: Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila publication-title: J. Neurosci. contributor: fullname: Ordway – volume: 118 start-page: 1077 year: 1993 end-page: 1088 ident: bib43 article-title: Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse publication-title: Development contributor: fullname: Perin – volume: 32 start-page: 673 year: 2001 end-page: 682 ident: bib50 article-title: Inactivity produces increases in neurotransmitter release and synapse size publication-title: Neuron contributor: fullname: Zhu – volume: 41 start-page: 521 year: 2004 end-page: 534 ident: bib17 article-title: Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila publication-title: Neuron contributor: fullname: Ganetzky – volume: 119 start-page: 1013 year: 2004 end-page: 1026 ident: bib24 article-title: Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins publication-title: Cell contributor: fullname: Craig – volume: 75 start-page: 237 year: 2006 end-page: 265 ident: bib26 article-title: Plasticity and second messengers during synapse development publication-title: Int. Rev. Neurobiol. contributor: fullname: Budnik – volume: 100 start-page: 1409 year: 2003 end-page: 1414 ident: bib30 article-title: A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Sudhof – volume: 24 start-page: 1406 year: 2004 end-page: 1415 ident: bib45 article-title: Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction publication-title: J. Neurosci. contributor: fullname: DiAntonio – volume: 16 start-page: 3877 year: 1996 end-page: 3886 ident: bib67 article-title: Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology publication-title: J. Neurosci. contributor: fullname: Atwood – volume: 101 start-page: 2607 year: 2004 end-page: 2612 ident: bib34 article-title: Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Missler – volume: 307 start-page: 1324 year: 2005 end-page: 1328 ident: bib13 article-title: Control of excitatory and inhibitory synapse formation by neuroligins publication-title: Science contributor: fullname: Scheiffele – volume: 26 start-page: 4256 year: 2006 end-page: 4265 ident: bib25 article-title: Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain publication-title: J. Neurosci. contributor: fullname: Craig – volume: 43 start-page: 193 year: 2004 end-page: 205 ident: bib37 article-title: Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis publication-title: Neuron contributor: fullname: Bellen – start-page: 265 year: 1998 end-page: 317 ident: bib16 article-title: Behaviour, learning, and memory publication-title: Drosophila, A Practical Approach contributor: fullname: Tully – volume: 79 start-page: 849 year: 2002 end-page: 859 ident: bib69 article-title: Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing publication-title: Genomics contributor: fullname: Sudhof – volume: 287 start-page: 2185 year: 2000 end-page: 2195 ident: bib1 article-title: The genome sequence of Drosophila melanogaster publication-title: Science contributor: fullname: Galle – volume: 9 start-page: 1411 year: 1999 end-page: 1414 ident: bib58 article-title: The endocytic machinery in nerve terminals surrounds sites of exocytosis publication-title: Curr. Biol. contributor: fullname: Kelly – volume: 87 start-page: 1059 year: 1996 end-page: 1068 ident: bib6 article-title: A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function publication-title: Cell contributor: fullname: Bellen – volume: 14 start-page: 20 year: 1998 end-page: 26 ident: bib48 article-title: Neurexins: three genes and 1001 products publication-title: Trends Genet. contributor: fullname: Sudhof – volume: 13 start-page: 507 year: 1994 end-page: 523 ident: bib41 article-title: Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance publication-title: Neuron contributor: fullname: Goodman – volume: 43 start-page: 207 year: 2004 end-page: 219 ident: bib44 article-title: Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth publication-title: Neuron contributor: fullname: Davis – volume: 24 start-page: 1037 year: 1999 end-page: 1047 ident: bib55 article-title: Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels publication-title: Neuron contributor: fullname: Peles – volume: 16 start-page: 2488 year: 1996 end-page: 2494 ident: bib29 article-title: CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins publication-title: J. Neurosci. contributor: fullname: Sudhof – volume: 15 start-page: 621 year: 2003 end-page: 632 ident: bib75 article-title: Synaptic adhesion molecules publication-title: Curr. Opin. Cell Biol. contributor: fullname: Weiner – volume: 581 start-page: 2509 year: 2007 end-page: 2516 ident: bib77 article-title: Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila publication-title: FEBS Lett. contributor: fullname: Xie – volume: 21 start-page: 1067 year: 1998 end-page: 1078 ident: bib52 article-title: Activity-dependent modulation of synaptic AMPA receptor accumulation publication-title: Neuron contributor: fullname: Huganir – volume: 88 start-page: 745 year: 1997 end-page: 746 ident: bib53 article-title: Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions publication-title: Cell contributor: fullname: Schlessinger – volume: 90 start-page: 3950 year: 2003 end-page: 3957 ident: bib21 article-title: Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors publication-title: J. Neurophysiol. contributor: fullname: Vicini – volume: 11 start-page: 2400 year: 2006 end-page: 2419 ident: bib23 article-title: Cell adhesion molecules at the synapse publication-title: Front. Biosci. contributor: fullname: El-Husseini – volume: 30 start-page: 369 year: 2001 end-page: 383 ident: bib9 article-title: Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin publication-title: Neuron contributor: fullname: Rosenbluth – volume: 17 start-page: 20 year: 2006 end-page: 30 ident: bib57 article-title: Development and structure of synaptic contacts in Drosophila publication-title: Semin. Cell Dev. Biol. contributor: fullname: Meinertzhagen – volume: 257 start-page: 50 year: 1992 end-page: 56 ident: bib73 article-title: Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin publication-title: Science contributor: fullname: Sudhof – volume: 79 start-page: 717 year: 1994 end-page: 727 ident: bib22 article-title: Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse publication-title: Cell contributor: fullname: Sudhof – volume: 101 start-page: 13915 year: 2004 end-page: 13920 ident: bib56 article-title: A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: El-Husseini – volume: 102 start-page: 6137 year: 2005 end-page: 6142 ident: bib51 article-title: Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Chen – volume: 154 start-page: 435 year: 2001 end-page: 445 ident: bib68 article-title: A stoichiometric complex of neurexins and dystroglycan in brain publication-title: J. Cell Biol. contributor: fullname: Sudhof – volume: 16 start-page: 1896 year: 1996 end-page: 1908 ident: bib27 article-title: A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures publication-title: Mol. Cell. Biol. contributor: fullname: Lim – volume: 275 start-page: 39803 year: 2000 end-page: 39806 ident: bib10 article-title: Mints as adaptors. Direct binding to neurexins and recruitment of munc18 publication-title: J. Biol. Chem. contributor: fullname: Sudhof – start-page: 175 year: 2000 end-page: 199 ident: bib7 article-title: The neuromuscular junction publication-title: contributor: fullname: Budnik – volume: 299 start-page: 265 year: 2003 end-page: 267 ident: bib2 article-title: Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing publication-title: Science contributor: fullname: Sekelsky – volume: 26 start-page: 357 year: 2000 end-page: 370 ident: bib31 article-title: Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development publication-title: Neuron contributor: fullname: Klambt – volume: 43 start-page: 207 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib44 article-title: Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth publication-title: Neuron doi: 10.1016/j.neuron.2004.07.001 contributor: fullname: Marie – volume: 104 start-page: 2525 year: 2007 ident: 10.1016/j.neuron.2007.08.002_bib4 article-title: Deletion of CASK in mice is lethal and impairs synaptic function publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0611003104 contributor: fullname: Atasoy – volume: 312 start-page: 1051 year: 2006 ident: 10.1016/j.neuron.2007.08.002_bib36 article-title: Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release publication-title: Science doi: 10.1126/science.1126308 contributor: fullname: Kittel – volume: 25 start-page: 4330 year: 2005 ident: 10.1016/j.neuron.2007.08.002_bib78 article-title: Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0497-05.2005 contributor: fullname: Zhang – volume: 119 start-page: 1013 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib24 article-title: Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins publication-title: Cell doi: 10.1016/j.cell.2004.11.035 contributor: fullname: Graf – volume: 5 start-page: 150 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib38 article-title: MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment publication-title: Brief. Bioinform. doi: 10.1093/bib/5.2.150 contributor: fullname: Kumar – volume: 90 start-page: 3950 year: 2003 ident: 10.1016/j.neuron.2007.08.002_bib21 article-title: Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors publication-title: J. Neurophysiol. doi: 10.1152/jn.00647.2003 contributor: fullname: Fu – volume: 154 start-page: 435 year: 2001 ident: 10.1016/j.neuron.2007.08.002_bib68 article-title: A stoichiometric complex of neurexins and dystroglycan in brain publication-title: J. Cell Biol. doi: 10.1083/jcb.200105003 contributor: fullname: Sugita – volume: 11 start-page: 2400 year: 2006 ident: 10.1016/j.neuron.2007.08.002_bib23 article-title: Cell adhesion molecules at the synapse publication-title: Front. Biosci. doi: 10.2741/1978 contributor: fullname: Gerrow – volume: 43 start-page: 193 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib37 article-title: Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis publication-title: Neuron doi: 10.1016/j.neuron.2004.06.029 contributor: fullname: Koh – volume: 26 start-page: 371 year: 2000 ident: 10.1016/j.neuron.2007.08.002_bib59 article-title: Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth publication-title: Neuron doi: 10.1016/S0896-6273(00)81170-8 contributor: fullname: Roos – volume: 14 start-page: 20 year: 1998 ident: 10.1016/j.neuron.2007.08.002_bib48 article-title: Neurexins: three genes and 1001 products publication-title: Trends Genet. doi: 10.1016/S0168-9525(97)01324-3 contributor: fullname: Missler – volume: 17 start-page: 627 year: 1996 ident: 10.1016/j.neuron.2007.08.002_bib12 article-title: Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg publication-title: Neuron doi: 10.1016/S0896-6273(00)80196-8 contributor: fullname: Budnik – volume: 21 start-page: 1067 year: 1998 ident: 10.1016/j.neuron.2007.08.002_bib52 article-title: Activity-dependent modulation of synaptic AMPA receptor accumulation publication-title: Neuron doi: 10.1016/S0896-6273(00)80624-8 contributor: fullname: O'Brien – volume: 307 start-page: 1324 year: 2005 ident: 10.1016/j.neuron.2007.08.002_bib13 article-title: Control of excitatory and inhibitory synapse formation by neuroligins publication-title: Science doi: 10.1126/science.1107470 contributor: fullname: Chih – volume: 19 start-page: 1237 year: 1997 ident: 10.1016/j.neuron.2007.08.002_bib54 article-title: Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release publication-title: Neuron doi: 10.1016/S0896-6273(00)80415-8 contributor: fullname: Petersen – volume: 26 start-page: 485 year: 2003 ident: 10.1016/j.neuron.2007.08.002_bib61 article-title: Cell-cell signaling during synapse formation in the CNS publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.26.043002.094940 contributor: fullname: Scheiffele – volume: 26 start-page: 357 year: 2000 ident: 10.1016/j.neuron.2007.08.002_bib31 article-title: Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development publication-title: Neuron doi: 10.1016/S0896-6273(00)81169-1 contributor: fullname: Hummel – volume: 19 start-page: 7793 year: 1999 ident: 10.1016/j.neuron.2007.08.002_bib72 article-title: The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.19-18-07793.1999 contributor: fullname: Torroja – volume: 24 start-page: 282 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib35 article-title: Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3553-03.2004 contributor: fullname: Kawasaki – volume: 79 start-page: 849 year: 2002 ident: 10.1016/j.neuron.2007.08.002_bib69 article-title: Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing publication-title: Genomics doi: 10.1006/geno.2002.6780 contributor: fullname: Tabuchi – volume: 79 start-page: 587 year: 2002 ident: 10.1016/j.neuron.2007.08.002_bib60 article-title: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity publication-title: Genomics doi: 10.1006/geno.2002.6734 contributor: fullname: Rowen – volume: 45 start-page: 12816 year: 2006 ident: 10.1016/j.neuron.2007.08.002_bib15 article-title: Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins publication-title: Biochemistry doi: 10.1021/bi0614131 contributor: fullname: Comoletti – volume: 26 start-page: 35 year: 2000 ident: 10.1016/j.neuron.2007.08.002_bib42 article-title: Ion channels and synaptic organization: analysis of the Drosophila genome publication-title: Neuron doi: 10.1016/S0896-6273(00)81135-6 contributor: fullname: Littleton – volume: 24 start-page: 1406 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib45 article-title: Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1575-03.2004 contributor: fullname: Marrus – volume: 16 start-page: 2488 year: 1996 ident: 10.1016/j.neuron.2007.08.002_bib29 article-title: CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.16-08-02488.1996 contributor: fullname: Hata – volume: 9 start-page: 1411 year: 1999 ident: 10.1016/j.neuron.2007.08.002_bib58 article-title: The endocytic machinery in nerve terminals surrounds sites of exocytosis publication-title: Curr. Biol. doi: 10.1016/S0960-9822(00)80087-1 contributor: fullname: Roos – volume: 127 start-page: 4157 year: 2000 ident: 10.1016/j.neuron.2007.08.002_bib65 article-title: Synaptic development is controlled in the periactive zones of Drosophila synapses publication-title: Development doi: 10.1242/dev.127.19.4157 contributor: fullname: Sone – volume: 423 start-page: 939 year: 2003 ident: 10.1016/j.neuron.2007.08.002_bib49 article-title: Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis publication-title: Nature doi: 10.1038/nature01755 contributor: fullname: Missler – start-page: 265 year: 1998 ident: 10.1016/j.neuron.2007.08.002_bib16 article-title: Behaviour, learning, and memory contributor: fullname: Connolly – volume: 96 start-page: 1100 year: 1999 ident: 10.1016/j.neuron.2007.08.002_bib66 article-title: Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.96.3.1100 contributor: fullname: Song – volume: 101 start-page: 15694 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib46 article-title: Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0406157101 contributor: fullname: McVey – volume: 287 start-page: 2185 year: 2000 ident: 10.1016/j.neuron.2007.08.002_bib1 article-title: The genome sequence of Drosophila melanogaster publication-title: Science doi: 10.1126/science.287.5461.2185 contributor: fullname: Adams – volume: 30 start-page: 369 year: 2001 ident: 10.1016/j.neuron.2007.08.002_bib9 article-title: Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin publication-title: Neuron doi: 10.1016/S0896-6273(01)00294-X contributor: fullname: Bhat – volume: 87 start-page: 1059 year: 1996 ident: 10.1016/j.neuron.2007.08.002_bib6 article-title: A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function publication-title: Cell doi: 10.1016/S0092-8674(00)81800-0 contributor: fullname: Baumgartner – volume: 41 start-page: 521 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib17 article-title: Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila publication-title: Neuron doi: 10.1016/S0896-6273(04)00016-9 contributor: fullname: Coyle – volume: 130 start-page: 173 year: 2003 ident: 10.1016/j.neuron.2007.08.002_bib19 article-title: Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila publication-title: Development doi: 10.1242/dev.00199 contributor: fullname: Deng – volume: 26 start-page: 481 year: 2007 ident: 10.1016/j.neuron.2007.08.002_bib63 article-title: Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy publication-title: EMBO J. doi: 10.1038/sj.emboj.7601503 contributor: fullname: Shcherbata – volume: 101 start-page: 2607 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib34 article-title: Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0308626100 contributor: fullname: Kattenstroth – volume: 88 start-page: 745 year: 1997 ident: 10.1016/j.neuron.2007.08.002_bib53 article-title: Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions publication-title: Cell doi: 10.1016/S0092-8674(00)81920-0 contributor: fullname: Peles – volume: 257 start-page: 50 year: 1992 ident: 10.1016/j.neuron.2007.08.002_bib73 article-title: Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin publication-title: Science doi: 10.1126/science.1621094 contributor: fullname: Ushkaryov – volume: 100 start-page: 1409 year: 2003 ident: 10.1016/j.neuron.2007.08.002_bib30 article-title: A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.252774899 contributor: fullname: Ho – volume: 280 start-page: 17312 year: 2005 ident: 10.1016/j.neuron.2007.08.002_bib40 article-title: Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity publication-title: J. Biol. Chem. doi: 10.1074/jbc.M413812200 contributor: fullname: Levinson – volume: 118 start-page: 1077 year: 1993 ident: 10.1016/j.neuron.2007.08.002_bib43 article-title: Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse publication-title: Development doi: 10.1242/dev.118.4.1077 contributor: fullname: Littleton – volume: 13 start-page: 507 year: 1994 ident: 10.1016/j.neuron.2007.08.002_bib41 article-title: Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance publication-title: Neuron doi: 10.1016/0896-6273(94)90022-1 contributor: fullname: Lin – volume: 17 start-page: 20 year: 2006 ident: 10.1016/j.neuron.2007.08.002_bib57 article-title: Development and structure of synaptic contacts in Drosophila publication-title: Semin. Cell Dev. Biol. doi: 10.1016/j.semcdb.2005.11.010 contributor: fullname: Prokop – volume: 299 start-page: 265 year: 2003 ident: 10.1016/j.neuron.2007.08.002_bib2 article-title: Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing publication-title: Science doi: 10.1126/science.1077198 contributor: fullname: Adams – volume: 48 start-page: 229 year: 2005 ident: 10.1016/j.neuron.2007.08.002_bib11 article-title: A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins publication-title: Neuron doi: 10.1016/j.neuron.2005.08.026 contributor: fullname: Boucard – volume: 10 start-page: 307 year: 1993 ident: 10.1016/j.neuron.2007.08.002_bib28 article-title: Interaction of synaptotagmin with the cytoplasmic domains of neurexins publication-title: Neuron doi: 10.1016/0896-6273(93)90320-Q contributor: fullname: Hata – volume: 131 start-page: 4931 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib20 article-title: Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function publication-title: Development doi: 10.1242/dev.01372 contributor: fullname: Faivre-Sarrailh – volume: 26 start-page: 4256 year: 2006 ident: 10.1016/j.neuron.2007.08.002_bib25 article-title: Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1253-05.2006 contributor: fullname: Graf – volume: 36 start-page: 283 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib71 article-title: A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac publication-title: Nat. Genet. doi: 10.1038/ng1314 contributor: fullname: Thibault – volume: 13 start-page: 823 year: 1994 ident: 10.1016/j.neuron.2007.08.002_bib39 article-title: The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure publication-title: Neuron doi: 10.1016/0896-6273(94)90249-6 contributor: fullname: Lahey – volume: 21 start-page: 444 year: 1998 ident: 10.1016/j.neuron.2007.08.002_bib8 article-title: Neurexin IV, caspr and paranodin–novel members of the neurexin family: encounters of axons and glia publication-title: Trends Neurosci. doi: 10.1016/S0166-2236(98)01267-3 contributor: fullname: Bellen – volume: 75 start-page: 237 year: 2006 ident: 10.1016/j.neuron.2007.08.002_bib26 article-title: Plasticity and second messengers during synapse development publication-title: Int. Rev. Neurobiol. doi: 10.1016/S0074-7742(06)75011-5 contributor: fullname: Griffith – volume: 49 start-page: 833 year: 2006 ident: 10.1016/j.neuron.2007.08.002_bib74 article-title: Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila publication-title: Neuron doi: 10.1016/j.neuron.2006.02.008 contributor: fullname: Wagh – volume: 24 start-page: 1037 year: 1999 ident: 10.1016/j.neuron.2007.08.002_bib55 article-title: Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels publication-title: Neuron doi: 10.1016/S0896-6273(00)81049-1 contributor: fullname: Poliak – volume: 16 start-page: 3877 year: 1996 ident: 10.1016/j.neuron.2007.08.002_bib67 article-title: Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.16-12-03877.1996 contributor: fullname: Stewart – volume: 101 start-page: 13915 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib56 article-title: A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0405939101 contributor: fullname: Prange – volume: 15 start-page: 621 year: 2003 ident: 10.1016/j.neuron.2007.08.002_bib75 article-title: Synaptic adhesion molecules publication-title: Curr. Opin. Cell Biol. doi: 10.1016/S0955-0674(03)00107-8 contributor: fullname: Yamagata – volume: 27 start-page: 2815 year: 2007 ident: 10.1016/j.neuron.2007.08.002_bib70 article-title: Silencing of neuroligin function by postsynaptic neurexins publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0032-07.2007 contributor: fullname: Taniguchi – volume: 51 start-page: 171 year: 2006 ident: 10.1016/j.neuron.2007.08.002_bib14 article-title: Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex publication-title: Neuron doi: 10.1016/j.neuron.2006.06.005 contributor: fullname: Chih – volume: 79 start-page: 717 year: 1994 ident: 10.1016/j.neuron.2007.08.002_bib22 article-title: Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse publication-title: Cell doi: 10.1016/0092-8674(94)90556-8 contributor: fullname: Geppert – volume: 26 start-page: 3319 year: 2006 ident: 10.1016/j.neuron.2007.08.002_bib5 article-title: Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5383-05.2006 contributor: fullname: Banerjee – volume: 277 start-page: 1511 year: 1997 ident: 10.1016/j.neuron.2007.08.002_bib33 article-title: Binding of neuroligins to PSD-95 publication-title: Science doi: 10.1126/science.277.5331.1511 contributor: fullname: Irie – volume: 581 start-page: 2509 year: 2007 ident: 10.1016/j.neuron.2007.08.002_bib77 article-title: Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila publication-title: FEBS Lett. doi: 10.1016/j.febslet.2007.04.068 contributor: fullname: Zeng – volume: 81 start-page: 435 year: 1995 ident: 10.1016/j.neuron.2007.08.002_bib32 article-title: Neuroligin 1: a splice site-specific ligand for beta-neurexins publication-title: Cell doi: 10.1016/0092-8674(95)90396-8 contributor: fullname: Ichtchenko – start-page: 175 year: 2000 ident: 10.1016/j.neuron.2007.08.002_bib7 article-title: The neuromuscular junction contributor: fullname: Bellen – volume: 16 start-page: 1896 year: 1996 ident: 10.1016/j.neuron.2007.08.002_bib27 article-title: A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.16.5.1896 contributor: fullname: Harden – volume: 16 start-page: 7868 year: 1996 ident: 10.1016/j.neuron.2007.08.002_bib64 article-title: A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.16-24-07868.1996 contributor: fullname: Smith – volume: 47 start-page: 724 year: 2004 ident: 10.1016/j.neuron.2007.08.002_bib47 article-title: The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2004.06.023 contributor: fullname: Meyer – volume: 36 start-page: 897 year: 2002 ident: 10.1016/j.neuron.2007.08.002_bib76 article-title: Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release publication-title: Neuron doi: 10.1016/S0896-6273(02)01065-6 contributor: fullname: Yoshihara – volume: 275 start-page: 39803 year: 2000 ident: 10.1016/j.neuron.2007.08.002_bib10 article-title: Mints as adaptors. Direct binding to neurexins and recruitment of munc18 publication-title: J. Biol. Chem. doi: 10.1074/jbc.C000656200 contributor: fullname: Biederer – volume: 25 start-page: 5943 year: 2005 ident: 10.1016/j.neuron.2007.08.002_bib3 article-title: Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1144-05.2005 contributor: fullname: Ashley – volume: 102 start-page: 6137 year: 2005 ident: 10.1016/j.neuron.2007.08.002_bib51 article-title: Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0502038102 contributor: fullname: Nam – volume: 101 start-page: 657 year: 2000 ident: 10.1016/j.neuron.2007.08.002_bib62 article-title: Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons publication-title: Cell doi: 10.1016/S0092-8674(00)80877-6 contributor: fullname: Scheiffele – volume: 6 start-page: 708 year: 2003 ident: 10.1016/j.neuron.2007.08.002_bib18 article-title: Neurexin mediates the assembly of presynaptic terminals publication-title: Nat. Neurosci. doi: 10.1038/nn1074 contributor: fullname: Dean – volume: 32 start-page: 673 year: 2001 ident: 10.1016/j.neuron.2007.08.002_bib50 article-title: Inactivity produces increases in neurotransmitter release and synapse size publication-title: Neuron doi: 10.1016/S0896-6273(01)00500-1 contributor: fullname: Murthy |
SSID | ssj0014591 |
Score | 2.3497415 |
Snippet | Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition. However, key evidence for this role in vivo... Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition. However, key evidence for this role in vivo... |
SourceID | pubmedcentral proquest crossref pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 741 |
SubjectTerms | Animals Cell adhesion & migration Cell Adhesion - genetics Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cell culture Cell Differentiation - genetics CELLBIO DEVBIO Drosophila melanogaster - embryology Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene Expression Regulation, Developmental - genetics Genes Genomes Insects Mammals Microscopy Molecular Sequence Data MOLNEURO Motor Neurons - metabolism Motor Neurons - ultrastructure Mutation - genetics Neuromuscular Junction - abnormalities Neuromuscular Junction - growth & development Neuromuscular Junction - metabolism Neurosciences Presynaptic Terminals - metabolism Presynaptic Terminals - ultrastructure Proteins Sequence Homology, Amino Acid Software Statistical analysis Synapses - genetics Synapses - metabolism Synapses - ultrastructure Synaptic Membranes - genetics Synaptic Membranes - metabolism Synaptic Membranes - ultrastructure Synaptic Transmission - genetics |
Title | Crucial Role of Drosophila Neurexin in Proper Active Zone Apposition to Postsynaptic Densities, Synaptic Growth, and Synaptic Transmission |
URI | https://dx.doi.org/10.1016/j.neuron.2007.08.002 https://www.ncbi.nlm.nih.gov/pubmed/17785181 https://www.proquest.com/docview/1503667442 https://search.proquest.com/docview/68240786 https://pubmed.ncbi.nlm.nih.gov/PMC2039911 |
Volume | 55 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELf2ISReEGzACmP4AfG0qPlwbPex6xiDIoQ2BhUvlp3YWtBwpjaT6L_AX82dk3QUkJCQIkWyk8jJXe5-d7n8jpAXuWDSSRdHRmoZsUwU0chhzFMUOWfg4bIyVPm-56cX7O0sn22QSf8vDJZVdra_tenBWncjw-5pDq-rangeyxGyl6PSolMSm2QbucxBtbfHR5-m71YfE1jeNs6D4yM8of-DLpR5BdpI33EZylV-5S8e6k8E-nsh5S-e6eQ-uddBSjpuV_2AbFi_Q3bHHsLpb0v6koYiz5A93yF32t6Ty13yYwJSBeWjZ_WVpbWjx_PQ0qC60hQZO-z3ylPYPmC2fk7HwS7SL7W3FJBrV-pFm5piu9_F0muwPQU9xnp45Gg9pOf92GuI9JvLQ6p9eTsYfCToGCbrHpKLk1cfJ6dR15ghKiDeaSKZOIgbixK8m3S5LAHW6JHMuZOpNTozzAiHPPc6FRoCxpIzo62LrTGlNIlNs0dky8N69wjVzMIFtIxHJWMQq4L5YNownrvCAvh3AxL1wlDXLf-G6gvTvqpWeNhKUyjsphmnAyJ6iak1PVLgIv5x5n4vYNW9xwsFcDnjXDAG089X0_B08LOK9ra-WSguMSqWfEAet9pwu1AhANDKBBa1pierA5Dbe33GV5eB4zuNATkmyZP_vp2n5G6bhkaSiX2y1cxv7DPAT4056N4P3E_PPk8PyOab2dFPoy0fmg |
link.rule.ids | 230,314,780,784,885,3506,27569,27924,27925,45663,45874 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKKwQXBC2PhUJ9QJwabR6O7T0uW8pClwrRFlVcLDux1aDiVLupxP4FfjUzTrJlAQkJKSfbiZzMZOabyeQbQl7mgkknXRwZqWXEMlFEI4cxT1HknIGHy8pQ5XvMp2fs_Xl-vkEm_b8wWFbZ2f7Wpgdr3Y0Mu6c5vKqq4UksR8hejkqLTkncIluABjgo-9b49eej2epjAsvbxnmwPsIT-j_oQplXoI30HZehXOVX_uKh_kSgvxdS_uKZDu-Tex2kpON21w_IhvXbZGfsIZz-tqSvaCjyDNnzbXK77T253CE_JiBVUD76qb60tHb0YB5aGlSXmiJjh_1eeQrHR8zWz-k42EX6pfaWAnLtSr1oU1Ns97tYeg22p6AHWA-PHK379KQfewuRfnOxT7UvbwaDjwQdw2TdQ3J2-OZ0Mo26xgxRAfFOE8nEQdxYlODdpMtlCbBGj2TOnUyt0ZlhRjjkudep0BAwlpwZbV1sjSmlSWyaPSKbHvb7hFDNLFxAy3hUMgaxKpgPpg3juSssgH83IFEvDHXV8m-ovjDtq2qFh600hcJumnE6IKKXmFrTIwUu4h9n7vYCVt17vFAAlzPOBWMwvbeahqeDn1W0t_X1QnGJUbHkA_K41YabjQoBgFYmsKk1PVktQG7v9RlfXQSO7zQG5JgkT__7dvbInenph5mavTs-ekbutilpJJzYJZvN_No-ByzVmBfdu_ITZrMf2A |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Crucial+Role+of+Drosophila+Neurexin+in+Proper+Active+Zone+Apposition+to+Postsynaptic+Densities%2C+Synaptic+Growth+and+Synaptic+Transmission&rft.jtitle=Neuron+%28Cambridge%2C+Mass.%29&rft.au=Li%2C+Jingjun&rft.au=Ashley%2C+James&rft.au=Budnik%2C+Vivian&rft.au=Bhat%2C+Manzoor+A.&rft.date=2007-09-06&rft.issn=0896-6273&rft.volume=55&rft.issue=5&rft.spage=741&rft.epage=755&rft_id=info:doi/10.1016%2Fj.neuron.2007.08.002&rft_id=info%3Apmid%2F17785181&rft.externalDBID=PMC2039911 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0896-6273&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0896-6273&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0896-6273&client=summon |