Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

• Published in: Nature communications Vol. 13; no. 1; pp. 3824 - 11
• Main Authors: Case, James Brett, Mackin, Samantha, Errico, John M., Chong, Zhenlu, Madden, Emily A., Whitener, Bradley, Guarino, Barbara, Schmid, Michael A., Rosenthal, Kim, Ren, Kuishu, Dang, Ha V., Snell, Gyorgy, Jung, Ana, Droit, Lindsay, Handley, Scott A., Halfmann, Peter J., Kawaoka, Yoshihiro, Crowe, James E., Fremont, Daved H., Virgin, Herbert W., Loo, Yueh-Ming, Esser, Mark T., Purcell, Lisa A., Corti, Davide, Diamond, Michael S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.07.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/106; 13/31; 631/250/2152/2153/1291; 631/326/596/4130; 64; 64/60; 82/1; 82/103; ACE2; Angiotensin-converting enzyme 2; Animals; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Antibodies, Neutralizing; Antibodies, Viral - therapeutic use; Biotechnology; Bronchopulmonary infection; Cell culture; Correlation analysis; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Glycoprotein S; Glycoproteins; Humanities and Social Sciences; Humans; Immunotherapy; Infections; Lungs; Membrane Glycoproteins; Mice; Monoclonal antibodies; multidisciplinary; Mutation; Neutralization; Neutralization Tests; Neutralizing; Resilience; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus; Spike protein; Transgenic mice; Viral diseases; Viral Envelope Proteins

Omicron variant strains encode large numbers of changes in the spike protein compared to historical SARS-CoV-2 isolates. Although in vitro studies have suggested that several monoclonal antibody therapies lose neutralizing activity against Omicron variants, the effects in vivo remain largely unknown...