Vitamin D metabolites and the gut microbiome in older men

• Published in: Nature communications Vol. 11; no. 1; pp. 5997 - 10
• Main Authors: Thomas, Robert L., Jiang, Lingjing, Adams, John S., Xu, Zhenjiang Zech, Shen, Jian, Janssen, Stefan, Ackermann, Gail, Vanderschueren, Dirk, Pauwels, Steven, Knight, Rob, Orwoll, Eric S., Kado, Deborah M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.11.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 101/58; 45; 45/23; 631/326/2565/2134; 692/163/2743; Aged; Aged, 80 and over; Biomedical materials; Butyrates - metabolism; Calcifediol - analysis; Calcifediol - metabolism; Calciferol; Calcitriol - analysis; Calcitriol - metabolism; Catabolism; Correlation analysis; Cross-Sectional Studies; Digestive system; DNA, Bacterial - isolation & purification; Feces - chemistry; Feces - microbiology; Fractures; Gastrointestinal Microbiome - physiology; Gastrointestinal system; Gastrointestinal tract; Gene expression; Gene sequencing; Gut microbiota; Humanities and Social Sciences; Humans; Independent Living; Intestinal microflora; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Male; Metabolites; Microbiomes; Microbiota; Microorganisms; multidisciplinary; Osteoporosis; Phylogeny; RNA, Ribosomal, 16S - genetics; rRNA; Science; Science (multidisciplinary); Variance analysis; Vitamin D

The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites...