Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins

• Published in: Nature communications Vol. 13; no. 1; pp. 531 - 13
• Main Authors: Miyakawa, Kei, Nishi, Mayuko, Ogawa, Michinaga, Matsunaga, Satoko, Sugiyama, Masaya, Nishitsuji, Hironori, Kimura, Hirokazu, Ohnishi, Makoto, Watashi, Koichi, Shimotohno, Kunitada, Wakita, Takaji, Ryo, Akihide
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 14/19; 14/28; 631/326/596; 631/326/88; 631/80/39; 82/47; Antiviral Agents - pharmacology; Antiviral drugs; Autophagosomes - metabolism; Autophagy; Autophagy - drug effects; Core protein; Crosstalk; Degradation; Ectopic expression; Galectin-9; Galectins - genetics; Galectins - metabolism; Galectins - pharmacology; Gene Expression; HEK293 Cells; Hep G2 Cells; Hepatitis; Hepatitis B; Hepatitis B virus - drug effects; Hepatitis B virus - metabolism; Hepatocytes; Humanities and Social Sciences; Humans; Immune response; Immune system; Innate immunity; Interferon; Macroautophagy - drug effects; multidisciplinary; Pathogens; Phagosomes; Proteins; Proteolysis; Replication; Science; Science (multidisciplinary); Sequestosome-1 Protein - genetics; Sequestosome-1 Protein - metabolism; Ubiquitination; Viral Core Proteins - metabolism; Viral infections; Virus Replication - drug effects

Autophagy has been linked to a wide range of functions, including a degradative process that defends host cells against pathogens. Although the involvement of autophagy in HBV infection has become apparent, it remains unknown whether selective autophagy plays a critical role in HBV restriction. Here...