A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction

• Published in: Nature communications Vol. 11; no. 1; pp. 4198 - 9
• Main Authors: Ejemel, Monir, Li, Qi, Hou, Shurong, Schiller, Zachary A., Tree, Julia A., Wallace, Aaron, Amcheslavsky, Alla, Kurt Yilmaz, Nese, Buttigieg, Karen R., Elmore, Michael J., Godwin, Kerry, Coombes, Naomi, Toomey, Jacqueline R., Schneider, Ryan, Ramchetty, Anudeep S., Close, Brianna J., Chen, Da-Yuan, Conway, Hasahn L., Saeed, Mohsan, Ganesa, Chandrashekar, Carroll, Miles W., Cavacini, Lisa A., Klempner, Mark S., Schiffer, Celia A., Wang, Yang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.08.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 101/1; 631/154/51/1568; 631/250/255/2514; 631/250/347; 631/535/1267; 82/1; ACE2; Angiotensin-Converting Enzyme 2; Animals; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - metabolism; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - metabolism; Betacoronavirus - immunology; Binding; Chlorocebus aethiops; COVID-19; Cross Reactions; Epitopes; HEK293 Cells; Humanities and Social Sciences; Humans; Immunity; Immunoglobulin A; Immunoglobulin A - immunology; Immunoglobulin A - metabolism; Immunoglobulin A, Secretory - immunology; Immunoglobulin A, Secretory - metabolism; Immunoglobulin G; Immunoglobulin G - immunology; Immunoglobulin G - metabolism; Models, Molecular; Monoclonal antibodies; Morbidity; Mucosal immunity; multidisciplinary; Mutation; Neutralization; Pandemics; Peptidyl-Dipeptidase A - metabolism; Protein Binding; Protein Interaction Domains and Motifs; Receptors; Respiratory system; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome-related coronavirus - immunology; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Vaccines; Vero Cells; Viral diseases; Viruses

COVID-19 caused by SARS-CoV-2 has become a global pandemic requiring the development of interventions for the prevention or treatment to curtail mortality and morbidity. No vaccine to boost mucosal immunity, or as a therapeutic, has yet been developed to SARS-CoV-2. In this study, we discover and ch...