The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis

• Published in: Nature communications Vol. 12; no. 1; pp. 6315 - 19
• Main Authors: Sekiya, Motohiro, Kainoh, Kenta, Sugasawa, Takehito, Yoshino, Ryunosuke, Hirokawa, Takatsugu, Tokiwa, Hiroaki, Nakano, Shogo, Nagatoishi, Satoru, Tsumoto, Kouhei, Takeuchi, Yoshinori, Miyamoto, Takafumi, Matsuzaka, Takashi, Shimano, Hitoshi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.11.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 38/39; 45/15; 45/41; 45/91; 631/337/572; 631/443/319/1642; 64/60; 692/699/317; 96/106; 96/35; Alcohol Oxidoreductases - genetics; Alcohol Oxidoreductases - metabolism; Animals; Cell Line; Co-Repressor Proteins - genetics; Co-Repressor Proteins - metabolism; Diabetes mellitus; Disease Models, Animal; Fatty liver; Fatty Liver - etiology; Fatty Liver - metabolism; Fatty Liver - pathology; Forkhead protein; FOXO1 protein; Gluconeogenesis; Glucose; Glucose - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Lipid metabolism; Lipids; Lipids - physiology; Lipogenesis; Liver; Liver - metabolism; Liver - pathology; Metabolism; Metabolites; Mice; Mice, Knockout; Mice, Obese; multidisciplinary; NADH; Nicotinamide adenine dinucleotide; Nutrient status; Obesity; Perturbation; Primary Cell Culture; Proteins; Science; Science (multidisciplinary); Steatosis; Sterol regulatory element-binding protein; Structure-function relationships; Transcription

Biological systems to sense and respond to metabolic perturbations are critical for the maintenance of cellular homeostasis. Here we describe a hepatic system in this context orchestrated by the transcriptional corepressor C-terminal binding protein 2 (CtBP2) that harbors metabolite-sensing capabili...