The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis - Sekiya, Motohiro; Kainoh, Kenta; Sugasawa, Takehito; Yoshino, Ryunosuke; Hirokawa, Takatsugu; Tokiwa, Hiroaki; Nakano, Shogo; Nagatoishi, Satoru; Tsumoto, Kouhei; Takeuchi, Yoshinori; Miyamoto, Takafumi; Matsuzaka, Takashi; et al. (Nature communications, 2021)
Keywords: 119/118; 38/39; 45/15; 45/41; 45/91; 631/337/572; 631/443/319/1642; 64/60; 692/699/317; 96/106; 96/35; Alcohol Oxidoreductases - genetics; Alcohol Oxidoreductases - metabolism; Animals; Cell Line; Co-Repressor Proteins - genetics; Co-Repressor Proteins - metabolism; Diabetes mellitus; Disease Models, Animal; Fatty liver; Fatty Liver - etiology; Fatty Liver - metabolism; Fatty Liver - pathology; Forkhead protein; FOXO1 protein; Gluconeogenesis; Glucose; Glucose - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Lipid metabolism; Lipids; Lipids - physiology; Lipogenesis; Liver; Liver - metabolism; Liver - pathology; Metabolism; Metabolites; Mice; Mice, Knockout; Mice, Obese; multidisciplinary; NADH; Nicotinamide adenine dinucleotide; Nutrient status; Obesity; Perturbation; Primary Cell Culture; Proteins; Science; Science (multidisciplinary); Steatosis; Sterol regulatory element-binding protein; Structure-function relationships; Transcription