High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy

• Published in: Cell death & disease Vol. 12; no. 2; pp. 216 - 15
• Main Authors: Wu, Qing-Rui, Zheng, Dan-Lin, Liu, Pei-Ming, Yang, Hui, Li, Lu-An, Kuang, Su-Juan, Lai, Ying-Yu, Rao, Fang, Xue, Yu-Mei, Lin, Ji-Jin, Liu, Shuang-Xin, Chen, Chun-Bo, Deng, Chun-Yu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.02.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 101/28; 13/1; 13/109; 13/51; 14/19; 14/28; 14/34; 631/337; 692/420; 692/699/75/74/1540; 82/80; 96/106; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Blood Glucose - metabolism; Calcium (mitochondrial); Calcium channels; Calcium influx; Calcium Signaling; Calcium signalling; Calcium-binding protein; Calmodulin; Cardiomyocytes; Cardiomyopathy; Cell Biology; Cell Culture; Cells, Cultured; Cyclosporin A; Dephosphorylation; Diabetes; Diabetes mellitus; Diabetic Cardiomyopathies - genetics; Diabetic Cardiomyopathies - metabolism; Diabetic Cardiomyopathies - pathology; Diabetic Cardiomyopathies - physiopathology; Disease Models, Animal; Dynamins - metabolism; Extracellular signal-regulated kinase; Extracellular Signal-Regulated MAP Kinases - metabolism; Heart; High fat diet; Hypertrophy; Hypertrophy, Left Ventricular - genetics; Hypertrophy, Left Ventricular - metabolism; Hypertrophy, Left Ventricular - pathology; Hypertrophy, Left Ventricular - physiopathology; Immunology; Kinases; Life Sciences; Male; Mice; Mitochondria; Mitochondria, Heart - genetics; Mitochondria, Heart - metabolism; Mitochondria, Heart - ultrastructure; Mitochondrial Dynamics; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - ultrastructure; Orai1 protein; ORAI1 Protein - genetics; ORAI1 Protein - metabolism; Phosphorylation; Rats; Rats, Sprague-Dawley; Rats, Zucker; Ribonucleic acid; RNA; Serine; Ventricular Function, Left; Ventricular Remodeling

Mitochondrial dysfunction and impaired Ca 2+ handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level of phosphorylation, and the Orai1 (Ca 2+ release-activated calcium channel protein 1) calciu...