Skin expression of IL-23 drives the development of psoriasis and psoriatic arthritis in mice

• Published in: Scientific reports Vol. 10; no. 1; pp. 8259 - 11
• Main Authors: Chen, Lili, Deshpande, Madhura, Grisotto, Marcos, Smaldini, Paola, Garcia, Roberto, He, Zhengxiang, Gulko, Percio S., Lira, Sergio A., Furtado, Glaucia C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.05.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/256; 692/420/2780; Animals; Arthritis; Arthritis, Psoriatic - genetics; Arthritis, Psoriatic - immunology; Cytokines; Dactylitis; Dermis; Female; Humanities and Social Sciences; Humans; Inflammation; Interleukin 22; Interleukin 23; Interleukin-23 - genetics; Interleukin-23 - immunology; Interleukins - genetics; Interleukins - immunology; Joint diseases; Male; Mice; multidisciplinary; Psoriasis; Psoriasis - genetics; Psoriasis - immunology; Psoriatic arthritis; Science; Science (multidisciplinary); Skin - immunology; Skin diseases; Transgenic animals

Psoriasis (PS) is a chronic skin inflammation. Up to 30% of the patients with PS develop psoriatic arthritis (PsA), a condition characterized by inflammatory arthritis that affects joints or entheses. Although there is mounting evidence for a critical role of interleukin-23 (IL-23) signaling in the...