Activation of SARS-CoV-2 neutralizing antibody is slower than elevation of spike-specific IgG, IgM, and nucleocapsid-specific IgG antibodies

• Published in: Scientific reports Vol. 12; no. 1; pp. 14909 - 10
• Main Authors: Takahashi, Maika, Ai, Tomohiko, Sinozuka, Konomi, Baba, Yuna, Igawa, Gene, Nojiri, Shuko, Yamamoto, Takamasa, Yuri, Maiko, Takei, Satomi, Saito, Kaori, Horiuchi, Yuki, Kanno, Takayuki, Tobiume, Minoru, Khasawneh, Abdullah, Paran, Faith Jessica, Hiki, Makoto, Wakita, Mitsuru, Miida, Takashi, Suzuki, Tadaki, Okuzawa, Atsushi, Takahashi, Kazuhisa, Naito, Toshio, Tabe, Yoko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/255/2514; 692/700/139/1420; Antibodies; Antibodies, Neutralizing; Antibodies, Viral; Chemiluminescence; COVID-19; COVID-19 Testing; Humanities and Social Sciences; Humans; Immune response; Immune response (humoral); Immunoglobulin G; Immunoglobulin M; multidisciplinary; Neutralization; Nucleocapsids; SARS-CoV-2; Science; Science (multidisciplinary); Sensitivity and Specificity; Serology; Severe acute respiratory syndrome coronavirus 2

COVID-19 antibody testing has been developed to investigate humoral immune response in SARS-CoV-2 infection. To assess the serological dynamics and neutralizing potency following SARS-CoV-2 infection, we investigated the neutralizing (NT) antibody, anti-spike, and anti-nucleocapsid antibodies respon...