Impact of neoadjuvant chemoradiotherapy followed by surgical resection on node-negative T3 and T4 non–small cell lung cancer

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 141; no. 6; pp. 1392 - 1397
• Main Authors: Daly, Benedict D.T., Ebright, Michael I., Walkey, Allan J., Fernando, Hiran C., Zaner, Ken S., Morelli, Donna M., Kachnic, Lisa A.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.06.2011; Elsevier
• Subjects: Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Boston; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - therapy; Cardiology. Vascular system; Cardiothoracic Surgery; Chemotherapy, Adjuvant; Chi-Square Distribution; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Male; Medical sciences; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Pneumology; Pneumonectomy; Proportional Hazards Models; Prospective Studies; Radiotherapy, Adjuvant; Risk Assessment; Risk Factors; Survival Rate; Time Factors; Treatment Outcome; Tumors of the respiratory system and mediastinum; Boston; CT; 10.4; FEV 1; 10.2; NSCLC; CI; HR; PET; computed tomography; non–small cell lung cancer; hazard ratio; confidence interval; forced expiratory volume in 1 second; positron emission tomography; Lung disease; Respiratory disease; Surgical resection; Malignant tumor; non-small cell lung carcinoma; Radiotherapy; Chemoradiotherapy; Neoadjuvant treatment; Chemotherapy; Treatment; Surgery; Bronchus disease; Anesthesia; Circulatory system; Cardiology; Cancer

This study examined the impact of neoadjuvant chemotherapy and concurrent high-dose radiation therapy on survival in patients with node-negative T3 and T4 non–small cell lung cancer. A total of 110 consecutive patients underwent surgical resection for invasive T3N0M0 (94 patients) and T4N0M0 (16 pat...