TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice

• Published in: Nature communications Vol. 13; no. 1; pp. 914 - 17
• Main Authors: Qin, Xunsi, Zhao, Yue, Zhang, Tianyi, Yin, Chenghong, Qiao, Jie, Guo, Wei, Lu, Bai
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.02.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/51; 13/95; 14/19; 38/91; 631/136/7; 631/154/556; 631/443/7; 64/60; 692/699/2732/1577; 96/1; 96/106; Adult; Aging; Aging (artificial); Aging (natural); Aging - physiology; Agonists; Animal models; Animals; Antibodies; Apoptosis; Apoptosis - drug effects; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - agonists; Brain-Derived Neurotrophic Factor - metabolism; Cell Line, Tumor; Chemical compounds; Cyclophosphamide; Cyclophosphamide - toxicity; Disease Models, Animal; Failure; Female; Fertility; Fertility - drug effects; Fertility Agents, Female - pharmacology; Fertility Agents, Female - therapeutic use; Follicles; Gametocytes; Granulosa cells; Humanities and Social Sciences; Humans; Infertility; Intravenous administration; Male; Maturation; Membrane Glycoproteins - agonists; Membrane Glycoproteins - metabolism; Mice; Middle Aged; multidisciplinary; Oocytes; Organ Culture Techniques; Ovaries; Ovary - drug effects; Ovary - pathology; Ovary - physiopathology; Pharmacology; Primary Ovarian Insufficiency - chemically induced; Primary Ovarian Insufficiency - drug therapy; Primary Ovarian Insufficiency - pathology; Primary Ovarian Insufficiency - physiopathology; Receptor, trkB - agonists; Receptor, trkB - metabolism; Receptors; Reproductive status; Science; Science (multidisciplinary); Signaling; TrkB receptors; Young Adult

Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. Here we show that intravenous injection of Ab4B19, an agonistic antibody for the BDNF receptor TrkB, penetrates into ovarian follicles, activates TrkB signaling, and promotes ovary development. In...