TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice - Qin, Xunsi; Zhao, Yue; Zhang, Tianyi; Yin, Chenghong; Qiao, Jie; Guo, Wei; Lu, Bai (Nature communications, 2022)
Keywords: 13/1; 13/51; 13/95; 14/19; 38/91; 631/136/7; 631/154/556; 631/443/7; 64/60; 692/699/2732/1577; 96/1; 96/106; Adult; Aging; Aging (artificial); Aging (natural); Aging - physiology; Agonists; Animal models; Animals; Antibodies; Apoptosis; Apoptosis - drug effects; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - agonists; Brain-Derived Neurotrophic Factor - metabolism; Cell Line, Tumor; Chemical compounds; Cyclophosphamide; Cyclophosphamide - toxicity; Disease Models, Animal; Failure; Female; Fertility; Fertility - drug effects; Fertility Agents, Female - pharmacology; Fertility Agents, Female - therapeutic use; Follicles; Gametocytes; Granulosa cells; Humanities and Social Sciences; Humans; Infertility; Intravenous administration; Male; Maturation; Membrane Glycoproteins - agonists; Membrane Glycoproteins - metabolism; Mice; Middle Aged; multidisciplinary; Oocytes; Organ Culture Techniques; Ovaries; Ovary - drug effects; Ovary - pathology; Ovary - physiopathology; Pharmacology; Primary Ovarian Insufficiency - chemically induced; Primary Ovarian Insufficiency - drug therapy; Primary Ovarian Insufficiency - pathology; Primary Ovarian Insufficiency - physiopathology; Receptor, trkB - agonists; Receptor, trkB - metabolism; Receptors; Reproductive status; Science; Science (multidisciplinary); Signaling; TrkB receptors; Young Adult