Heterogeneous dissociation process of truncated RNAs by oligomerized Vasa helicase

• Published in: Communications biology Vol. 4; no. 1; pp. 1386 - 7
• Main Authors: Kinoshita, Yoshimi, Murakami, Ryo, Muto, Nao, Kubo, Shintaroh, Iizuka, Ryo, Uemura, Sotaro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 101/1; 631/337/2265; 631/57/2265; 82/83; Animals; Biology; Biomedical and Life Sciences; Bombyx - enzymology; Bombyx - genetics; Cytoplasm; DEAD-box RNA Helicases - genetics; DEAD-box RNA Helicases - metabolism; DNA helicase; Double-stranded RNA; Electrostatic properties; Enzymes; Glass substrates; Insect Proteins - genetics; Insect Proteins - metabolism; Life Sciences; Metabolism; Oligomerization; RNA helicase; RNA Interference; RNA, Small Interfering - genetics; Single Molecule Imaging; Transcription; Unwinding

RNA helicases are enzymes that generally unwind double-stranded RNA using ATP hydrolysis energy, mainly involved in RNA metabolism, transcription, translation, and mRNA splicing. While the helicase core is crucial for RNA unwinding activity, N- and C-terminal extensions of specific helicases may con...