Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair

• Published in: Communications biology Vol. 4; no. 1; p. 146
• Main Authors: Molenaar, Bas, Timmer, Louk T., Droog, Marjolein, Perini, Ilaria, Versteeg, Danielle, Kooijman, Lieneke, Monshouwer-Kloots, Jantine, de Ruiter, Hesther, Gladka, Monika M., van Rooij, Eva
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 38/91; 45/77; 631/337/2019; 631/80/86; 64/60; 96/63; 96/95; Animals; beta 2-Microglobulin - genetics; beta 2-Microglobulin - metabolism; Biology; Biomedical and Life Sciences; Cardiomyocytes; Cell Line; Cell signaling; Congestive heart failure; Disease Models, Animal; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Gene expression; Gene Expression Profiling; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - pathology; Ischemia; Life Sciences; Macrophages - metabolism; Macrophages - pathology; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury - genetics; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocardial Reperfusion Injury - physiopathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Paracrine Communication; Paracrine signalling; Single-Cell Analysis; Therapeutic applications; Time Factors; Transcription; Transcriptome; Ventricular Remodeling; Wound Healing

The efficiency of the repair process following ischemic cardiac injury is a crucial determinant for the progression into heart failure and is controlled by both intra- and intercellular signaling within the heart. An enhanced understanding of this complex interplay will enable better exploitation of...