MRNIP condensates promote DNA double-strand break sensing and end resection

• Published in: Nature communications Vol. 13; no. 1; pp. 2638 - 16
• Main Authors: Wang, Yun-Long, Zhao, Wan-Wen, Bai, Shao-Mei, Feng, Li-Li, Bie, Shu-Ying, Gong, Li, Wang, Fang, Wei, Ming-Biao, Feng, Wei-Xing, Pang, Xiao-Lin, Qin, Cao-Litao, Yin, Xin-Ke, Wang, Ying-Nai, Zhou, Weihua, Wahl, Daniel R., Liu, Quentin, Chen, Ming, Hung, Mien-Chie, Wan, Xiang-Bo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 14/1; 14/19; 14/3; 14/35; 14/63; 38; 38/77; 38/89; 42/109; 42/41; 631/337/1427/2122; 631/45/612; 631/67/1059/485; 64/60; 82/51; Condensates; Damage; Deoxyribonucleic acid; DNA; DNA damage; Double-strand break repair; Homologous recombination; Homology; Humanities and Social Sciences; Microprocessors; MRE11 protein; multidisciplinary; Phase separation; Radioresistance; Repair; Science; Science (multidisciplinary); Xenografts; Xenotransplantation; Yeast

The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1 (MRN) complex is critical for the initiation of DNA damage response and DSB end resection. Here, we show that MRN complex interacting protein (MRNIP) forms liquid-like condensates to promote homologous recombination-med...