Segmental Hyperalgesia to Mechanical Stimulus in Interstitial Cystitis/Bladder Pain Syndrome: Evidence of Central Sensitization

• Published in: The Journal of urology Vol. 191; no. 5; pp. 1294 - 1299
• Main Authors: Lai, H. Henry, Gardner, Vivien, Ness, Timothy J, Gereau, Robert W
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2014; Elsevier
• Subjects: Adult; Aged; Biological and medical sciences; Central Nervous System Sensitization; cystitis; Cystitis, Interstitial - complications; Cystitis, Interstitial - physiopathology; Humans; hyperalgesia; Hyperalgesia - etiology; interstitial; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Pain Measurement; Pain Threshold; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Urology; Young Adult; BPS; DH; central nervous system sensitization; dorsal horn; interstitial; VAS; visual analog scale; pain measurement; QST; bladder pain syndrome; IC; cystitis; hyperalgesia; interstitial cystitis; quantitative sensory testing; Nephrology; Urinary system disease; Central nervous system; Urinary tract disease; Syndrome; Urology; Pain; Urinary system; Urinary bladder; Segmental; Bladder disease; Interstitial; Sensitization; Mechanical stimulus; Interstitial cystitis; Quantitative analysis

Purpose We investigate if subjects with interstitial cystitis/bladder pain syndrome demonstrate mechanical or thermal hyperalgesia, and whether the hyperalgesia is segmental or generalized (global). Materials and Methods Ten female subjects with interstitial cystitis/bladder pain syndrome and 10 age...