SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

• Published in: Nature communications Vol. 13; no. 1; pp. 5135 - 8
• Main Authors: Sano, Kaori, Bhavsar, Disha, Singh, Gagandeep, Floda, Daniel, Srivastava, Komal, Gleason, Charles, Carreño, Juan Manuel, Simon, Viviana, Krammer, Florian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/2152; 631/250/590/2293; 631/326/596/4130; 692/699/255/2514; 82/1; Antibodies; Antibodies, Viral; Antibody Formation; Antigens; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - immunology; Humanities and Social Sciences; Humans; Immune response; Immune system; Immunoglobulin A; Immunoglobulin A, Secretory; Infections; Influenza; Medicine; mRNA; Mucosa; multidisciplinary; Pandemics; Respiratory diseases; RNA, Messenger; Saliva; SARS-CoV-2 - immunology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus; Vaccination; Viral diseases

Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with...