Vms1p is a release factor for the ribosome-associated quality control complex

• Published in: Nature communications Vol. 9; no. 1; pp. 2197 - 9
• Main Authors: Zurita Rendón, Olga, Fredrickson, Eric K., Howard, Conor J., Van Vranken, Jonathan, Fogarty, Sarah, Tolley, Neal D., Kalia, Raghav, Osuna, Beatriz A., Shen, Peter S., Hill, Christopher P., Frost, Adam, Rutter, Jared
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.06.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 14; 42/70; 45/88; 631/45/474/1768; 631/80/642/333; 82/29; 82/80; 96/31; 96/35; Adenosine triphosphatase; Alanine; Amino Acid Sequence; Carrier Proteins - genetics; Carrier Proteins - metabolism; Chain mobility; Chains; Cytosol; Elongation; Homeostasis; Humanities and Social Sciences; Hydrolase; Lysine; Mitochondria; multidisciplinary; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; Organelles; Peptides - genetics; Peptides - metabolism; Polypeptides; Proteasomes; Protein Binding; Protein Biosynthesis - genetics; Proteins; Quality Control; Ribosome Subunits, Large, Eukaryotic - genetics; Ribosome Subunits, Large, Eukaryotic - metabolism; Ribosomes; RNA, Transfer, Amino Acyl - genetics; RNA, Transfer, Amino Acyl - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Science; Science (multidisciplinary); Sequence Homology, Amino Acid; Stalling; Threonine; tRNA; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Valosin Containing Protein - genetics; Valosin Containing Protein - metabolism

Eukaryotic cells employ the ribosome-associated quality control complex (RQC) to maintain homeostasis despite defects that cause ribosomes to stall. The RQC comprises the E3 ubiquitin ligase Ltn1p, the ATPase Cdc48p, Rqc1p, and Rqc2p. Upon ribosome stalling and splitting, the RQC assembles on the 60...