4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects - Liao, Shan-Ting; Han, Chao; Xu, Ding-Qiao; Fu, Xiao-Wei; Wang, Jun-Song; Kong, Ling-Yi (Nature communications, 2019)
Keywords: 13; 13/1; 13/21; 38; 38/77; 42; 42/109; 631/250/2504/342; 631/250/256/2516; 631/443/319; 631/45/320; 64; 64/60; 82/58; Alkylates; Alkylation; Animals; Antimetabolites - pharmacology; Cysteine - drug effects; Cysteine - genetics; Cysteine - metabolism; Deoxyglucose - pharmacology; Down-Regulation; Endotoxemia - immunology; Enzymatic activity; Enzyme activity; Enzymes; Glucose - metabolism; Glyceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - antagonists & inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - drug effects; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - metabolism; Glycolysis; Glycolysis - drug effects; Humanities and Social Sciences; Inflammation - immunology; Inflammatory diseases; Interleukin-1beta - drug effects; Interleukin-1beta - immunology; Lethality; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Macrophage Activation - immunology; Macrophages; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Metabolites; Mice; multidisciplinary; Nitric Oxide Synthase Type II - drug effects; Nitric Oxide Synthase Type II - immunology; Oxidative phosphorylation; Oxidative Phosphorylation - drug effects; Phosphorylation; RAW 264.7 Cells; Science; Science (multidisciplinary); Sesquiterpenes - pharmacology; Succinates - pharmacology; Therapeutic applications