Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

• Published in: Translational psychiatry Vol. 11; no. 1; pp. 251 - 15
• Main Authors: Lyra e Silva, Natalia M., Gonçalves, Rafaella A., Pascoal, Tharick A., Lima-Filho, Ricardo A. S., Resende, Elisa de Paula França, Vieira, Erica L. M., Teixeira, Antonio L., de Souza, Leonardo C., Peny, Julyanna A., Fortuna, Juliana T. S., Furigo, Isadora C., Hashiguchi, Debora, Miya-Coreixas, Vivian S., Clarke, Julia R., Abisambra, Jose F., Longo, Beatriz M., Donato, Jose, Fraser, Paul E., Rosa-Neto, Pedro, Caramelli, Paulo, Ferreira, Sergio T., De Felice, Fernanda G.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.04.2021; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/51; 45/77; 59/57; 631/378/340; 64/110; 64/60; 692/699; 82/29; Alzheimer Disease; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animals; Behavioral Sciences; Biological Psychology; Cognitive Dysfunction; Cytokines; Hippocampus - diagnostic imaging; Hippocampus - metabolism; Humans; Hypothalamus; Interleukin-6; Magnetic resonance imaging; Medicine; Medicine & Public Health; Memory; Metabolism; Mice; Neurosciences; Pharmacotherapy; Plaque, Amyloid; Psychiatry

Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of pro-inflammatory pathways in the brain, including the interle...