Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

• Published in: Nature communications Vol. 11; no. 1; pp. 791 - 12
• Main Authors: Boyoglu-Barnum, Seyhan, Hutchinson, Geoffrey B., Boyington, Jeffrey C., Moin, Syed M., Gillespie, Rebecca A., Tsybovsky, Yaroslav, Stephens, Tyler, Vaile, John R., Lederhofer, Julia, Corbett, Kizzmekia S., Fisher, Brian E., Yassine, Hadi M., Andrews, Sarah F., Crank, Michelle C., McDermott, Adrian B., Mascola, John R., Graham, Barney S., Kanekiyo, Masaru
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.02.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 13/1; 13/109; 631/250/2152/2153; 631/250/590; 631/326/596/1578; 631/45/612/1231; 64/60; 82/16; 82/83; Access control; Animals; Antibodies; Antibodies, Viral - immunology; Antibody Specificity; Asparagine - chemistry; Asparagine - metabolism; Broadly Neutralizing Antibodies - immunology; Cross Reactions; Epitopes; Epitopes - immunology; Female; Glycan; Glycosylation; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Hemagglutinins; Humanities and Social Sciences; Immunoglobulins; Immunoglobulins - immunology; Influenza; Influenza A; Influenza A Virus, H7N9 Subtype - pathogenicity; Influenza Vaccines - immunology; Mice, Inbred BALB C; multidisciplinary; Nanoparticles; Nanoparticles - chemistry; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; Polysaccharides - chemistry; Science; Science (multidisciplinary); Vaccines; Viruses

The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the protection does not extend to group 2 viruses, due in part to differences in gl...