Changes to the cervicovaginal microbiota and cervical cytokine profile following surgery for cervical intraepithelial neoplasia

• Published in: Scientific reports Vol. 11; no. 1; pp. 2156 - 12
• Main Authors: Kawahara, Rina, Fujii, Takuma, Kukimoto, Iwao, Nomura, Hiroyuki, Kawasaki, Rie, Nishio, Eiji, Ichikawa, Ryoko, Tsukamoto, Tetsuya, Iwata, Aya
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/127; 631/250/2499; 631/326/2565/2134; 631/67/1517/1371; 692/699/255/2514; Cytokines; DNA sequencing; Eotaxin; Genomics; Genotypes; Human papillomavirus; Humanities and Social Sciences; IL-1β; Immune clearance; Immune response; Immunoassays; Immunomodulation; Infections; Microbiomes; Microbiota; multidisciplinary; rRNA 16S; Science; Science (multidisciplinary); Surgery; Tumor necrosis factor-α

Persistent HPV infection associated with immune modulation may result in high-grade squamous intraepithelial lesions (CIN)2/3. Currently, there is little information on the cervicovaginal microbiome, local cytokine levels and HPV infection related to CIN. Follow-up of patients after local surgery pr...