Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

• Published in: Nature communications Vol. 9; no. 1; pp. 3763 - 18
• Main Authors: Lee, Chih-Chan, Lin, Jiunn-Chang, Hwang, Wei-Lun, Kuo, Ying-Ju, Chen, Hung-Kai, Tai, Shyh-Kuan, Lin, Chun-Chi, Yang, Muh-Hwa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.09.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13/109; 13/31; 13/51; 13/95; 14/19; 14/5; 14/63; 38/39; 38/61; 38/79; 59/5; 631/67/322; 631/67/327; 64/110; 64/60; 82/29; A549 Cells; Animals; Cancer; Cell Line, Tumor; Cell Plasticity - immunology; Colonization; Cytokines; Epithelial-Mesenchymal Transition; GATA-3 protein; GATA3 Transcription Factor - metabolism; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; HEK293 Cells; Humanities and Social Sciences; Humans; Inflammation; Interleukin 1; Interleukins - immunology; Interleukins - metabolism; Janus kinase 2; Janus Kinase 2 - metabolism; Macrophages; Macrophages - immunology; Macrophages - metabolism; Markers; MCF-7 Cells; Mesenchyme; Metastases; Metastasis; Mice; multidisciplinary; Neoplasm Metastasis - immunology; Neutralization; Receptors, Interleukin-12 - genetics; Science; Science (multidisciplinary); Signal Transduction; Stat6 protein; STAT6 Transcription Factor - metabolism; Tumor Microenvironment - immunology; Tumors

A favorable interplay between cancer cells and the tumor microenvironment (TME) facilitates the outgrowth of metastatic tumors. Because of the distinct initiating processes between primary and metastatic tumors, we investigate the differences in tumor-associated macrophages (TAMs) from primary and m...