Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer

• Published in: Nature communications Vol. 13; no. 1; pp. 6658 - 15
• Main Authors: Damrauer, Jeffrey S., Beckabir, Wolfgang, Klomp, Jeff, Zhou, Mi, Plimack, Elizabeth R., Galsky, Matthew D., Grivas, Petros, Hahn, Noah M., O’Donnell, Peter H., Iyer, Gopa, Quinn, David I., Vincent, Benjamin G., Quale, Diane Zipursky, Wobker, Sara E., Hoadley, Katherine A., Kim, William Y., Milowsky, Matthew I.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.11.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 38; 45; 45/23; 45/91; 631/67/1059/2325; 631/67/322; 631/67/589/1336; 692/4025/1334; 692/4028/67/69; Bladder; Bladder cancer; Cancer; Cancer therapies; Carcinoma, Transitional Cell - genetics; Chemotherapy; Computer applications; DNA sequencing; Genomes; Genomic analysis; Genomics; High-Throughput Nucleotide Sequencing; Humanities and Social Sciences; Humans; Immune checkpoint inhibitors; Inflammation; Metastases; Metastasis; multidisciplinary; Mutation; Next-generation sequencing; Patients; Phenotypes; Repositories; Science; Science (multidisciplinary); Stroma; Tumors; Urinary Bladder - pathology; Urinary Bladder Neoplasms - pathology; Urothelial cancer; Urothelial carcinoma

Urothelial Cancer - Genomic Analysis to Improve Patient Outcomes and Research (NCT02643043), UC-GENOME, is a genomic analysis and biospecimen repository study in 218 patients with metastatic urothelial carcinoma. Here we report on the primary outcome of the UC-GENOME—the proportion of subjects who r...