PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus

• Published in: Nature communications Vol. 12; no. 1; pp. 2829 - 13
• Main Authors: Chen, Li, Tong, Qiaoqiao, Chen, Xiaowen, Jiang, Penglei, Yu, Hua, Zhao, Qianbing, Sun, Lingang, Liu, Chao, Gu, Bin, Zheng, Yuping, Fei, Lijiang, Jiang, Xiao, Li, Wenjuan, Volpe, Giacomo, Abdul, Mazid MD, Guo, Guoji, Zhang, Jin, Qian, Pengxu, Sun, Qiming, Neculai, Dante, Esteban, Miguel A., Li, Chen, Wen, Feiqiu, Ji, Junfeng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.05.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/100; 38; 38/91; 631/136/2444; 631/337/176; 631/337/572; 631/532/2064/2117; Ablation; Cell fate; Chromatin; Depletion; Gene expression; Gene silencing; Genomes; Humanities and Social Sciences; Loci; Maintenance; multidisciplinary; Pluripotency; Polycomb group proteins; Proteins; Science; Science (multidisciplinary); Transcription

Polycomb group (PcG) proteins maintain cell identity by repressing gene expression during development. Surprisingly, emerging studies have recently reported that a number of PcG proteins directly activate gene expression during cell fate determination process. However, the mechanisms by which they d...