Genome sequence of the bioplastic-producing “Knallgas” bacterium Ralstonia eutropha H16

The H 2 -oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H 2 and CO 2 as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50...

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Published in	Nature biotechnology Vol. 24; no. 10; pp. 1257 - 1262
Main Authors	Pohlmann, Anne, Fricke, Wolfgang Florian, Reinecke, Frank, Kusian, Bernhard, Liesegang, Heiko, Cramm, Rainer, Eitinger, Thomas, Ewering, Christian, Pötter, Markus, Schwartz, Edward, Strittmatter, Axel, Voß, Ingo, Gottschalk, Gerhard, Steinbüchel, Alexander, Friedrich, Bärbel, Bowien, Botho
Format	Journal Article
Language	English
Published	New York Nature Publishing Group US 01.10.2006 Nature Nature Publishing Group
Subjects	Aerobiosis Agriculture Anaerobiosis Bacteria Bacterial Toxins - genetics Bacterial Toxins - metabolism Biodegradable materials Biodegradation Bioinformatics Biological and medical sciences Biological Transport Biology of microorganisms of confirmed or potential industrial interest Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Bioplastics Biotechnology Carbon - metabolism Carbon dioxide Chromosomes Chromosomes, Bacterial Cupriavidus necator - genetics Cupriavidus necator - metabolism Fundamental and applied biological sciences. Psychology Genetics Genome, Bacterial Genomics Hydroxybutyrates - metabolism Life Sciences Mission oriented research Molecular Sequence Data Plastics Polyesters Polyesters - metabolism Ralstonia eutropha Ralstonia eutropha Gene Biodegradability Ester polymer Bacteria Butyrate(hydroxy)polymer Chromosome Genetics Oxidation Genome Plastics Metabolism
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Abstract	The H 2 -oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H 2 and CO 2 as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[ R -(–)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together, chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility.
AbstractList	The H 2 -oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H 2 and CO 2 as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[ R -(–)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together, chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility. The H(2)-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H(2) and CO(2) as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[R-(-)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together, chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility. The H sub(2)-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H sub(2) and CO sub(2) as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[R-(-)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility. The H(2)-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H(2) and CO(2) as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[R-(-)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together, chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility.The H(2)-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H(2) and CO(2) as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[R-(-)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together, chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility.
Audience	Academic
Author	Cramm, Rainer Schwartz, Edward Reinecke, Frank Liesegang, Heiko Ewering, Christian Pötter, Markus Kusian, Bernhard Steinbüchel, Alexander Friedrich, Bärbel Eitinger, Thomas Voß, Ingo Gottschalk, Gerhard Pohlmann, Anne Bowien, Botho Strittmatter, Axel Fricke, Wolfgang Florian
Author_xml	– sequence: 1 givenname: Anne surname: Pohlmann fullname: Pohlmann, Anne organization: Humboldt-Universität zu Berlin, Institut für Biologie/Mikrobiologie, Chausseestraße 117 – sequence: 2 givenname: Wolfgang Florian surname: Fricke fullname: Fricke, Wolfgang Florian organization: Georg-August-Universität Göttingen, Laboratorium für Genomanalyse, Grisebachstraße 8, Georg-August-Universität Göttingen, Institut für Mikrobiologie und Genetik, Grisebachstraße 8 – sequence: 3 givenname: Frank surname: Reinecke fullname: Reinecke, Frank organization: Westfälische Wilhelms-Universität Münster, Institut für Molekulare Mikrobiologie und Biotechnologie, Corrensstraße 3 – sequence: 4 givenname: Bernhard surname: Kusian fullname: Kusian, Bernhard organization: Georg-August-Universität Göttingen, Institut für Mikrobiologie und Genetik, Grisebachstraße 8 – sequence: 5 givenname: Heiko surname: Liesegang fullname: Liesegang, Heiko organization: Georg-August-Universität Göttingen, Laboratorium für Genomanalyse, Grisebachstraße 8 – sequence: 6 givenname: Rainer surname: Cramm fullname: Cramm, Rainer organization: Humboldt-Universität zu Berlin, Institut für Biologie/Mikrobiologie, Chausseestraße 117 – sequence: 7 givenname: Thomas surname: Eitinger fullname: Eitinger, Thomas organization: Humboldt-Universität zu Berlin, Institut für Biologie/Mikrobiologie, Chausseestraße 117 – sequence: 8 givenname: Christian surname: Ewering fullname: Ewering, Christian organization: Westfälische Wilhelms-Universität Münster, Institut für Molekulare Mikrobiologie und Biotechnologie, Corrensstraße 3 – sequence: 9 givenname: Markus surname: Pötter fullname: Pötter, Markus organization: Westfälische Wilhelms-Universität Münster, Institut für Molekulare Mikrobiologie und Biotechnologie, Corrensstraße 3 – sequence: 10 givenname: Edward surname: Schwartz fullname: Schwartz, Edward organization: Humboldt-Universität zu Berlin, Institut für Biologie/Mikrobiologie, Chausseestraße 117 – sequence: 11 givenname: Axel surname: Strittmatter fullname: Strittmatter, Axel organization: Georg-August-Universität Göttingen, Laboratorium für Genomanalyse, Grisebachstraße 8 – sequence: 12 givenname: Ingo surname: Voß fullname: Voß, Ingo organization: Westfälische Wilhelms-Universität Münster, Institut für Molekulare Mikrobiologie und Biotechnologie, Corrensstraße 3 – sequence: 13 givenname: Gerhard surname: Gottschalk fullname: Gottschalk, Gerhard organization: Georg-August-Universität Göttingen, Laboratorium für Genomanalyse, Grisebachstraße 8 – sequence: 14 givenname: Alexander surname: Steinbüchel fullname: Steinbüchel, Alexander organization: Westfälische Wilhelms-Universität Münster, Institut für Molekulare Mikrobiologie und Biotechnologie, Corrensstraße 3 – sequence: 15 givenname: Bärbel surname: Friedrich fullname: Friedrich, Bärbel email: baerbel.friedrich@rz.hu-berlin.de organization: Humboldt-Universität zu Berlin, Institut für Biologie/Mikrobiologie, Chausseestraße 117 – sequence: 16 givenname: Botho surname: Bowien fullname: Bowien, Botho organization: Georg-August-Universität Göttingen, Institut für Mikrobiologie und Genetik, Grisebachstraße 8
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18218431$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/16964242$$D View this record in MEDLINE/PubMed
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Snippet	The H 2 -oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic... The H(2)-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic... The H sub(2)-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic...
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SubjectTerms	Aerobiosis Agriculture Anaerobiosis Bacteria Bacterial Toxins - genetics Bacterial Toxins - metabolism Biodegradable materials Biodegradation Bioinformatics Biological and medical sciences Biological Transport Biology of microorganisms of confirmed or potential industrial interest Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Bioplastics Biotechnology Carbon - metabolism Carbon dioxide Chromosomes Chromosomes, Bacterial Cupriavidus necator - genetics Cupriavidus necator - metabolism Fundamental and applied biological sciences. Psychology Genetics Genome, Bacterial Genomics Hydroxybutyrates - metabolism Life Sciences Mission oriented research Molecular Sequence Data Plastics Polyesters Polyesters - metabolism Ralstonia eutropha
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Title	Genome sequence of the bioplastic-producing “Knallgas” bacterium Ralstonia eutropha H16
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