SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters

Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different r...

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Published inNature communications Vol. 12; no. 1; pp. 4985 - 15
Main Authors Port, Julia R., Yinda, Claude Kwe, Owusu, Irene Offei, Holbrook, Myndi, Fischer, Robert, Bushmaker, Trenton, Avanzato, Victoria A., Schulz, Jonathan E., Martens, Craig, van Doremalen, Neeltje, Clancy, Chad S., Munster, Vincent J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 17.08.2021
Nature Publishing Group
Nature Portfolio
Subjects
13
13/106
13/21
13/51
38/39
38/77
38/90
38/91
45
631/326/596/2563
631/326/596/4130
Administration, Intranasal
Aerosols
Air flow
Animals
COVID-19
COVID-19 - blood
COVID-19 - transmission
COVID-19 - virology
Cytokines - blood
Disease transmission
Exposure
Female
Fomites
Hamsters
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Inflammation
Inoculation
Lung - virology
Mesocricetus
multidisciplinary
Nasal Cavity - virology
Particle Size
Pathogenesis
Respiratory pathology
Respiratory System - virology
RNA, Viral - genetics
Rodents
SARS-CoV-2 - isolation & purification
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Transmission efficiency
Vaccination
Viral diseases
Virus Replication
Virus Shedding
Viruses
Weight loss
Online AccessGet full text

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Abstract Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different routes of exposure present with distinct disease manifestations. Intranasal and aerosol inoculation causes severe respiratory pathology, higher virus loads and increased weight loss. In contrast, fomite exposure leads to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Whereas the overall magnitude of respiratory virus shedding is not linked to disease severity, the onset of shedding is. Early shedding is linked to an increase in disease severity. Airborne transmission is more efficient than fomite transmission and dependent on the direction of the airflow. Carefully characterized SARS-CoV-2 transmission models will be crucial to assess potential changes in transmission and pathogenic potential in the light of the ongoing SARS-CoV-2 evolution. Here, Port and Yinda et al. directly compare the relative contribution of contact, fomite, and airborne transmission route of SARS-CoV-2 to disease outcome in Syrian hamsters; while intranasal and aerosol inoculation causes severe pathogenesis, fomite exposure is characterized by milder disease.
AbstractList Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different routes of exposure present with distinct disease manifestations. Intranasal and aerosol inoculation causes severe respiratory pathology, higher virus loads and increased weight loss. In contrast, fomite exposure leads to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Whereas the overall magnitude of respiratory virus shedding is not linked to disease severity, the onset of shedding is. Early shedding is linked to an increase in disease severity. Airborne transmission is more efficient than fomite transmission and dependent on the direction of the airflow. Carefully characterized SARS-CoV-2 transmission models will be crucial to assess potential changes in transmission and pathogenic potential in the light of the ongoing SARS-CoV-2 evolution. Here, Port and Yinda et al. directly compare the relative contribution of contact, fomite, and airborne transmission route of SARS-CoV-2 to disease outcome in Syrian hamsters; while intranasal and aerosol inoculation causes severe pathogenesis, fomite exposure is characterized by milder disease.
Here, Port and Yinda et al. directly compare the relative contribution of contact, fomite, and airborne transmission route of SARS-CoV-2 to disease outcome in Syrian hamsters; while intranasal and aerosol inoculation causes severe pathogenesis, fomite exposure is characterized by milder disease.
Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different routes of exposure present with distinct disease manifestations. Intranasal and aerosol inoculation causes severe respiratory pathology, higher virus loads and increased weight loss. In contrast, fomite exposure leads to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Whereas the overall magnitude of respiratory virus shedding is not linked to disease severity, the onset of shedding is. Early shedding is linked to an increase in disease severity. Airborne transmission is more efficient than fomite transmission and dependent on the direction of the airflow. Carefully characterized SARS-CoV-2 transmission models will be crucial to assess potential changes in transmission and pathogenic potential in the light of the ongoing SARS-CoV-2 evolution.
Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different routes of exposure present with distinct disease manifestations. Intranasal and aerosol inoculation causes severe respiratory pathology, higher virus loads and increased weight loss. In contrast, fomite exposure leads to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Whereas the overall magnitude of respiratory virus shedding is not linked to disease severity, the onset of shedding is. Early shedding is linked to an increase in disease severity. Airborne transmission is more efficient than fomite transmission and dependent on the direction of the airflow. Carefully characterized SARS-CoV-2 transmission models will be crucial to assess potential changes in transmission and pathogenic potential in the light of the ongoing SARS-CoV-2 evolution.Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different routes of exposure present with distinct disease manifestations. Intranasal and aerosol inoculation causes severe respiratory pathology, higher virus loads and increased weight loss. In contrast, fomite exposure leads to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Whereas the overall magnitude of respiratory virus shedding is not linked to disease severity, the onset of shedding is. Early shedding is linked to an increase in disease severity. Airborne transmission is more efficient than fomite transmission and dependent on the direction of the airflow. Carefully characterized SARS-CoV-2 transmission models will be crucial to assess potential changes in transmission and pathogenic potential in the light of the ongoing SARS-CoV-2 evolution.
Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different routes of exposure present with distinct disease manifestations. Intranasal and aerosol inoculation causes severe respiratory pathology, higher virus loads and increased weight loss. In contrast, fomite exposure leads to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Whereas the overall magnitude of respiratory virus shedding is not linked to disease severity, the onset of shedding is. Early shedding is linked to an increase in disease severity. Airborne transmission is more efficient than fomite transmission and dependent on the direction of the airflow. Carefully characterized SARS-CoV-2 transmission models will be crucial to assess potential changes in transmission and pathogenic potential in the light of the ongoing SARS-CoV-2 evolution.Here, Port and Yinda et al. directly compare the relative contribution of contact, fomite, and airborne transmission route of SARS-CoV-2 to disease outcome in Syrian hamsters; while intranasal and aerosol inoculation causes severe pathogenesis, fomite exposure is characterized by milder disease.
ArticleNumber 4985
Author Port, Julia R.
Yinda, Claude Kwe
Owusu, Irene Offei
Munster, Vincent J.
Schulz, Jonathan E.
van Doremalen, Neeltje
Clancy, Chad S.
Bushmaker, Trenton
Holbrook, Myndi
Martens, Craig
Fischer, Robert
Avanzato, Victoria A.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34404778$$D View this record in MEDLINE/PubMed
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SSID ssj0000391844
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Snippet Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject...
Here, Port and Yinda et al. directly compare the relative contribution of contact, fomite, and airborne transmission route of SARS-CoV-2 to disease outcome in...
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COVID-19 - virology
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Disease transmission
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multidisciplinary
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Respiratory System - virology
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Title SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters
URI https://link.springer.com/article/10.1038/s41467-021-25156-8
https://www.ncbi.nlm.nih.gov/pubmed/34404778
https://www.proquest.com/docview/2562072857
https://www.proquest.com/docview/2562517492
https://pubmed.ncbi.nlm.nih.gov/PMC8371001
https://doaj.org/article/4a4ae0743895463b83727995473e62dd
Volume 12
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