Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

• Published in: Nature communications Vol. 11; no. 1; p. 4395
• Main Authors: Udakis, Matt, Pedrosa, Victor, Chamberlain, Sophie E. L., Clopath, Claudia, Mellor, Jack R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.09.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 631/378/116/1925; 631/378/1595/1554; 631/378/2591/2595; 9/74; Action Potentials; Activity patterns; Animals; CA1 Region, Hippocampal - cytology; CA1 Region, Hippocampal - physiology; Calcium; Calcium channels (T-type); Calcium Channels, T-Type - metabolism; Channelrhodopsins - metabolism; Circuits; Cortex (entorhinal); Hippocampus; Hippocampus - cytology; Hippocampus - physiology; Humanities and Social Sciences; Interneurons; Interneurons - metabolism; Light; Long-term depression; Long-term potentiation; Mice; multidisciplinary; Neurons; Optogenetics - methods; Parvalbumin; Parvalbumins - metabolism; Patch-Clamp Techniques; Photovoltaic cells; Plastic properties; Plasticity; Pyramidal cells; Pyramidal Cells - physiology; Representations; Science; Science (multidisciplinary); Signal Transduction; Somatostatin; Somatostatin - metabolism; Spatial discrimination; Synapses; Synapses - metabolism; Synaptic depression; Synaptic strength

The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse interneuron populations. Although it is known that inhibitory synaptic strength is malleable, induction of long-term plasticity at distinct inhibito...