Tick saliva-induced programmed death-1 and PD-ligand 1 and its related host immunosuppression

• Published in: Scientific reports Vol. 11; no. 1; pp. 1063 - 11
• Main Authors: Sajiki, Yamato, Konnai, Satoru, Ikenaka, Yoshinori, Gulay, Kevin Christian Montecillo, Kobayashi, Atsushi, Parizi, Luís Fernando, João, Benvindo Capela, Watari, Kei, Fujisawa, Sotaro, Okagawa, Tomohiro, Maekawa, Naoya, Logullo, Carlos, da Silva Vaz, Itabajara, Murata, Shiro, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 692/420; Animal husbandry; Apoptosis; Cattle; CD11c antigen; CD14 antigen; CD69 antigen; Cytokines; Ectoparasites; Flow cytometry; Humanities and Social Sciences; Immunosuppression; Immunosuppressive agents; Leukocytes (mononuclear); Ligands; Lymphocytes T; multidisciplinary; Parasites; PD-1 protein; PD-L1 protein; Peripheral blood mononuclear cells; Prostaglandin E2; Saliva; Science; Science (multidisciplinary); γ-Interferon

The tick Rhipicephalus microplus is a harmful parasite of cattle that causes considerable economic losses to the cattle breeding industry. Although R . microplus saliva (Rm-saliva) contains several immunosuppressants, any association between Rm-saliva and the expression of immunoinhibitory molecules...