Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury

• Published in: Journal of neuroinflammation Vol. 17; no. 1; pp. 1 - 17
• Main Authors: Fan, Hong, Tang, Hai-Bin, Chen, Zhe, Wang, Hu-Qing, Zhang, Lei, Jiang, Yu, Li, Tao, Yang, Cai-Feng, Wang, Xiao-Ya, Li, Xia, Wu, Sheng-Xi, Zhang, Gui-Lian
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 09.10.2020; BioMed Central; BMC
• Subjects: Advanced glycosylation end products; Antibodies; Astrocytes; Brain damage; Complications and side effects; Demyelination; DNA binding proteins; Enzyme-linked immunosorbent assay; Gene expression; Glial fibrillary acidic protein; Glycosylation; Glycyrrhizin; Health aspects; High mobility group proteins; HMGB1; HMGB1 protein; Immunohistochemistry; Inflammation; Kinases; Macrophages; Macrophages/microglia; Microglia; Myelin; Necroptosis; Neuroprotection; NF-κB protein; Phenotypes; Physiological aspects; Polarization; Polymerase chain reaction; Prevention; Proteins; RAGE; Recovery of function; Risk factors; Spinal cord injuries; Spinal cord injury; Trauma; China

Background Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only a transient appearance of anti-inflammatory phenotype of immune cells. However, the mechanisms controlling this special sterile inflammation after SCI are still not fully elucid...