Immunological and inflammatory profiles in mild and severe cases of COVID-19
COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19....
Saved in:
| Published in | Nature communications Vol. 11; no. 1; pp. 3410 - 10 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
08.07.2020
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients.
Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild. |
|---|---|
| AbstractList | Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild. COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients.COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients. COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients. Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild. COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients.Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild. COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients. |
| ArticleNumber | 3410 |
| Author | Song, Jin-Wen Meng, Fan-Ping Wang, Si-Yu Zhang, Da-Wei Xu, Zhe Wang, Fu-Sheng Ippolito, Giuseppe Yang, Tao Fan, Xing Xu, Ruo-Nan Shi, Ming Dai, Xiao-Peng Zhang, Ji-Yuan Jiang, Tian-Jun Xia, Peng Zumla, Alimuddin Agrati, Chiara Zhang, Chao Cao, Wen-Jing Li, Wen-Gang Maeurer, Markus Zhao, Peng |
| Author_xml | – sequence: 1 givenname: Jin-Wen orcidid: 0000-0002-8582-8012 surname: Song fullname: Song, Jin-Wen organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 2 givenname: Chao surname: Zhang fullname: Zhang, Chao organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 3 givenname: Xing orcidid: 0000-0002-0809-9207 surname: Fan fullname: Fan, Xing organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 4 givenname: Fan-Ping surname: Meng fullname: Meng, Fan-Ping organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 5 givenname: Zhe surname: Xu fullname: Xu, Zhe organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 6 givenname: Peng surname: Xia fullname: Xia, Peng organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 7 givenname: Wen-Jing surname: Cao fullname: Cao, Wen-Jing organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Department of Clinical Medicine, Bengbu Medical College – sequence: 8 givenname: Tao surname: Yang fullname: Yang, Tao organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 9 givenname: Xiao-Peng surname: Dai fullname: Dai, Xiao-Peng organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 10 givenname: Si-Yu surname: Wang fullname: Wang, Si-Yu organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 11 givenname: Ruo-Nan surname: Xu fullname: Xu, Ruo-Nan organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 12 givenname: Tian-Jun surname: Jiang fullname: Jiang, Tian-Jun organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 13 givenname: Wen-Gang surname: Li fullname: Li, Wen-Gang organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 14 givenname: Da-Wei surname: Zhang fullname: Zhang, Da-Wei organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 15 givenname: Peng surname: Zhao fullname: Zhao, Peng organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 16 givenname: Ming surname: Shi fullname: Shi, Ming organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 17 givenname: Chiara surname: Agrati fullname: Agrati, Chiara organization: National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS- Via Portuense – sequence: 18 givenname: Giuseppe orcidid: 0000-0002-1076-2979 surname: Ippolito fullname: Ippolito, Giuseppe organization: National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS- Via Portuense – sequence: 19 givenname: Markus orcidid: 0000-0002-8436-8077 surname: Maeurer fullname: Maeurer, Markus organization: Immunotherapy Programme, Champalimaud Centre for the Unknown, I Med Clinic, University of Mainz – sequence: 20 givenname: Alimuddin surname: Zumla fullname: Zumla, Alimuddin organization: Department of Infection, Division of Infection and Immunity, University College London, National Institute for Health Research Biomedical Research Centre, University College London Hospitals NHS Foundation Trust – sequence: 21 givenname: Fu-Sheng orcidid: 0000-0002-8043-6685 surname: Wang fullname: Wang, Fu-Sheng email: fswang302@163.com organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases – sequence: 22 givenname: Ji-Yuan orcidid: 0000-0003-4781-4477 surname: Zhang fullname: Zhang, Ji-Yuan email: uniquezjy@163.com organization: Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32641700$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Uk1v1DAQtVAR_aB_gAOKxIVLwB57k_iChBYKK63UC3C1_JXFK8de7KRS_z3OppS2h_pie-a95zfjOUcnIQaL0BuCPxBMu4-ZEda0NQZckxYYruEFOgPMyHylJw_Op-gy5z0ui3LSMfYKnVJoGGkxPkPbzTBMIfq4c1r6SgZTudB7OQxyjOm2OqTYO29ziVaD8-aIyPbGJltpmUsi9tX6-tfmS034a_Sylz7by7v9Av28-vpj_b3eXn_brD9va93gZqyZgYYTq6UluCPQrEzHDQewLaaKW8Ol7jkHblYYQClYccX0SmrcdyApBXqBNouuiXIvDskNMt2KKJ04BmLaCZlGp70VPeVMcdwo1VJmsJEdI4rK0jauoLVN0fq0aB0mNVijbRiT9I9EH2eC-y128UYUPdp2pAi8vxNI8c9k8ygGl7X1XgYbpyyAAWBSbM_Qd0-g-zilUFo1owgwSpvZ0duHju6t_Pu0AoAFoFPMOdn-HkKwmIdDLMMhSpXiOBxi7ln3hKTdKEcX56qcf55KF2ou74SdTf9tP8P6C5Tiyys |
| CitedBy_id | crossref_primary_10_1186_s12879_024_09772_5 crossref_primary_10_1371_journal_pone_0273969 crossref_primary_10_3389_fmolb_2021_813175 crossref_primary_10_4103_ejh_ejh_40_21 crossref_primary_10_3389_fimmu_2021_666163 crossref_primary_10_4049_jimmunol_2300434 crossref_primary_10_1016_j_ebiom_2022_103920 crossref_primary_10_1055_s_0041_1729343 crossref_primary_10_1186_s40560_021_00531_1 crossref_primary_10_3390_biomedicines10051002 crossref_primary_10_3389_fmed_2021_761372 crossref_primary_10_1016_j_molmed_2023_09_003 crossref_primary_10_1038_s41598_020_79035_1 crossref_primary_10_1016_j_gim_2022_04_005 crossref_primary_10_1111_all_14647 crossref_primary_10_1093_pcmedi_pbae015 crossref_primary_10_1016_j_jaci_2023_12_011 crossref_primary_10_1002_adhm_202300404 crossref_primary_10_1111_imb_12838 crossref_primary_10_1111_syen_12510 crossref_primary_10_1016_j_heliyon_2023_e17148 crossref_primary_10_1016_j_cellimm_2021_104454 crossref_primary_10_1016_j_jaci_2022_06_017 crossref_primary_10_1038_s43856_023_00268_y crossref_primary_10_3389_fimmu_2021_700152 crossref_primary_10_1016_j_sjbs_2020_11_006 crossref_primary_10_3389_fcell_2021_725606 crossref_primary_10_1016_j_molimm_2021_06_001 crossref_primary_10_4103_epj_epj_96_23 crossref_primary_10_1007_s12275_022_1624_z crossref_primary_10_3389_fimmu_2023_1167639 crossref_primary_10_1186_s12931_022_02284_3 crossref_primary_10_1093_jmcb_mjab067 crossref_primary_10_1021_acs_jproteome_1c00156 crossref_primary_10_1002_jmv_28192 crossref_primary_10_1016_j_immuni_2020_12_002 crossref_primary_10_1111_cla_12490 crossref_primary_10_1007_s11356_022_19025_0 crossref_primary_10_1016_j_intimp_2022_109132 crossref_primary_10_1172_jci_insight_183810 crossref_primary_10_3390_molecules27123651 crossref_primary_10_1186_s13054_020_03440_1 crossref_primary_10_3389_fimmu_2021_735125 crossref_primary_10_3389_fimmu_2020_598402 crossref_primary_10_1016_j_celrep_2021_109432 crossref_primary_10_1016_j_lfs_2021_119376 crossref_primary_10_1038_s41392_023_01471_y crossref_primary_10_3389_fmolb_2022_975322 crossref_primary_10_1007_s00011_024_01857_w crossref_primary_10_1089_jir_2023_0075 crossref_primary_10_3389_fpls_2020_601335 crossref_primary_10_1177_10815589231158041 crossref_primary_10_3390_cells11213359 crossref_primary_10_1096_fj_202100024R crossref_primary_10_1016_j_antiviral_2022_105373 crossref_primary_10_1016_j_modpat_2023_100378 crossref_primary_10_1016_j_jaci_2023_01_022 crossref_primary_10_1186_s12014_022_09377_7 crossref_primary_10_17816_CI630148 crossref_primary_10_1038_s41423_020_00557_9 crossref_primary_10_1097_CCM_0000000000005098 crossref_primary_10_3389_fmolb_2022_835590 crossref_primary_10_1016_j_imbio_2023_152755 crossref_primary_10_1016_j_pharmthera_2022_108121 crossref_primary_10_4018_JGIM_300818 crossref_primary_10_1038_s41598_020_75618_0 crossref_primary_10_3390_ijms24109047 crossref_primary_10_1001_jamapsychiatry_2021_2274 crossref_primary_10_3390_v14061201 crossref_primary_10_33549_physiolres_934759 crossref_primary_10_1038_s41423_021_00750_4 crossref_primary_10_2147_JBM_S365218 crossref_primary_10_1002_jcla_24046 crossref_primary_10_1038_s41467_020_18854_2 crossref_primary_10_3389_fmed_2022_1009557 crossref_primary_10_1016_j_intimp_2021_107685 crossref_primary_10_3390_microorganisms9071438 crossref_primary_10_1038_s41598_021_94256_8 crossref_primary_10_3389_fmolb_2023_1158133 crossref_primary_10_23736_S2724_5683_24_06501_3 crossref_primary_10_3389_fimmu_2022_1066176 crossref_primary_10_1177_17534259221077750 crossref_primary_10_3390_ijms232113656 crossref_primary_10_1186_s13063_021_05625_7 crossref_primary_10_3389_fmicb_2020_588409 crossref_primary_10_3390_immuno1030020 crossref_primary_10_3390_covid2030025 crossref_primary_10_3389_fimmu_2024_1464545 crossref_primary_10_3390_pathogens11050563 crossref_primary_10_3389_fimmu_2022_973070 crossref_primary_10_1016_j_heliyon_2021_e05990 crossref_primary_10_1038_s41598_022_23923_1 crossref_primary_10_1002_cti2_1292 crossref_primary_10_3389_fimmu_2020_586765 crossref_primary_10_1038_s42003_024_07350_8 crossref_primary_10_1093_oxfimm_iqab016 crossref_primary_10_1186_s13148_023_01515_8 crossref_primary_10_1016_j_ebiom_2021_103794 crossref_primary_10_1016_j_celrep_2023_112613 crossref_primary_10_1016_j_cell_2020_10_037 crossref_primary_10_1080_17476348_2021_1850278 crossref_primary_10_4103_aihb_aihb_99_21 crossref_primary_10_1186_s43055_022_00917_7 crossref_primary_10_1016_j_it_2020_11_002 crossref_primary_10_3390_ijms24021712 crossref_primary_10_1038_s41467_021_27745_z crossref_primary_10_3389_fimmu_2021_652223 crossref_primary_10_1111_imm_13564 crossref_primary_10_3389_fbioe_2022_1052436 crossref_primary_10_3389_fimmu_2021_674279 crossref_primary_10_1038_s41392_021_00488_5 crossref_primary_10_3389_fimmu_2023_1107803 crossref_primary_10_3389_fimmu_2023_1222170 crossref_primary_10_1146_annurev_med_042220_012417 crossref_primary_10_4081_jphia_2023_2242 crossref_primary_10_1007_s11154_021_09630_8 crossref_primary_10_1016_j_virol_2021_01_002 crossref_primary_10_1097_ID9_0000000000000075 crossref_primary_10_25259_AJBPS_1_2022 crossref_primary_10_5812_jjm_130316 crossref_primary_10_31631_2073_3046_2024_23_2_50_60 crossref_primary_10_1016_j_isci_2021_103295 crossref_primary_10_1038_s41467_025_58173_y crossref_primary_10_3390_vaccines11030659 crossref_primary_10_3389_fimmu_2022_1053437 crossref_primary_10_1016_j_intimp_2024_112419 crossref_primary_10_3389_fimmu_2022_861666 crossref_primary_10_3389_fphar_2021_643619 crossref_primary_10_1136_rmdopen_2020_001549 crossref_primary_10_1007_s12288_022_01558_6 crossref_primary_10_1016_j_celrep_2020_108590 crossref_primary_10_1016_j_jsps_2021_01_005 crossref_primary_10_1001_jamapsychiatry_2020_4442 crossref_primary_10_1371_journal_ppat_1009761 crossref_primary_10_1007_s00109_021_02175_y crossref_primary_10_1183_13993003_01374_2022 crossref_primary_10_3390_v13030378 crossref_primary_10_1016_j_hrtlng_2021_01_011 crossref_primary_10_1016_j_ccc_2021_05_004 crossref_primary_10_1007_s00011_021_01517_3 crossref_primary_10_1089_vim_2021_0022 crossref_primary_10_1038_s41423_023_00985_3 crossref_primary_10_1371_journal_pone_0314754 crossref_primary_10_1099_jmm_0_001591 crossref_primary_10_3389_fimmu_2021_769442 crossref_primary_10_1016_j_ebiom_2022_104299 crossref_primary_10_1182_blood_2021013549 crossref_primary_10_3389_fimmu_2021_733921 crossref_primary_10_1038_s41598_021_04344_y crossref_primary_10_1111_sji_13131 crossref_primary_10_1007_s12072_023_10631_9 crossref_primary_10_3389_fimmu_2020_603389 crossref_primary_10_3390_jcm11071880 crossref_primary_10_3389_fimmu_2022_1116160 crossref_primary_10_3389_fgene_2022_845474 crossref_primary_10_2174_1381612828666220926094730 crossref_primary_10_7554_eLife_86014 crossref_primary_10_3390_jpm13081235 crossref_primary_10_1097_01_ID9_0000733572_40970_6c crossref_primary_10_1002_eji_202049135 crossref_primary_10_1002_jev2_12173 crossref_primary_10_1016_j_celrep_2021_110126 crossref_primary_10_2147_IJGM_S337604 crossref_primary_10_1016_j_media_2021_102096 crossref_primary_10_3389_fimmu_2022_1070994 crossref_primary_10_4110_in_2021_21_e2 crossref_primary_10_4049_jimmunol_2101123 crossref_primary_10_3389_fimmu_2021_815651 crossref_primary_10_1002_ddr_21752 crossref_primary_10_3390_covid1020042 crossref_primary_10_3390_ijms22137017 crossref_primary_10_1097_BS9_0000000000000132 crossref_primary_10_1177_20406223211041924 crossref_primary_10_7717_peerj_18451 crossref_primary_10_14348_molcells_2021_0079 crossref_primary_10_1038_s41392_020_00286_5 crossref_primary_10_3389_fcell_2021_695362 crossref_primary_10_1016_j_etap_2020_103520 crossref_primary_10_3389_fimmu_2021_741796 crossref_primary_10_1007_s11655_021_3313_x crossref_primary_10_1111_sji_12967 crossref_primary_10_3389_fimmu_2021_789735 crossref_primary_10_1111_syen_12586 crossref_primary_10_3748_wjg_v28_i47_6716 crossref_primary_10_1017_erm_2022_12 crossref_primary_10_3390_vaccines9060596 crossref_primary_10_34172_ijep_5614 crossref_primary_10_1371_journal_ppat_1009850 crossref_primary_10_1007_s40265_020_01421_w crossref_primary_10_1016_j_jbior_2021_100818 crossref_primary_10_1007_s00705_023_05842_2 crossref_primary_10_1126_sciimmunol_abe4782 crossref_primary_10_1016_j_smim_2021_101505 crossref_primary_10_1093_infdis_jiaa713 crossref_primary_10_2174_2772270816666220318103929 crossref_primary_10_3390_ijms24031996 crossref_primary_10_1016_j_clim_2022_109177 crossref_primary_10_3390_jcm13195664 crossref_primary_10_1016_j_smim_2021_101508 crossref_primary_10_1002_jmv_28122 crossref_primary_10_2147_IJGM_S321292 crossref_primary_10_1002_sim_9447 crossref_primary_10_1097_QAI_0000000000003399 crossref_primary_10_1126_science_abe4832 crossref_primary_10_1111_febs_16077 crossref_primary_10_4103_ijmr_IJMR_453_21 crossref_primary_10_3389_fcvm_2020_629933 crossref_primary_10_3390_ijerph20021578 crossref_primary_10_3389_fimmu_2022_894534 crossref_primary_10_1515_nipt_2022_0003 crossref_primary_10_1038_s42003_024_05922_2 crossref_primary_10_3390_biom12030445 crossref_primary_10_1016_j_heliyon_2021_e07147 crossref_primary_10_3390_antiox11101862 crossref_primary_10_3389_fimmu_2023_1077236 crossref_primary_10_1172_JCI142081 crossref_primary_10_1080_22221751_2022_2150566 crossref_primary_10_3389_fimmu_2023_1266659 crossref_primary_10_1016_j_xcrm_2021_100291 crossref_primary_10_1016_j_ijbiomac_2021_10_144 crossref_primary_10_1016_j_intimp_2024_113934 crossref_primary_10_1021_acs_jproteome_1c00977 crossref_primary_10_3390_v16071006 crossref_primary_10_1016_j_ebiom_2023_104932 crossref_primary_10_1111_all_15372 crossref_primary_10_3389_fimmu_2022_834942 crossref_primary_10_1172_JCI149834 crossref_primary_10_3390_pathogens12020321 crossref_primary_10_1177_11772719221106600 crossref_primary_10_1002_jmv_29357 crossref_primary_10_1111_bjh_18062 crossref_primary_10_1016_j_molimm_2021_04_021 crossref_primary_10_3390_jpm14050503 crossref_primary_10_3390_pathogens11111256 crossref_primary_10_1016_j_mjafi_2021_02_008 crossref_primary_10_2174_1566523221666210907162005 crossref_primary_10_1631_jzus_B2000304 crossref_primary_10_1002_eji_202049163 crossref_primary_10_1016_j_cyto_2023_156434 crossref_primary_10_1186_s12929_022_00872_5 crossref_primary_10_3389_fimmu_2023_1143350 crossref_primary_10_7554_eLife_78200 crossref_primary_10_52586_4999 crossref_primary_10_1016_j_intimp_2020_107082 crossref_primary_10_3389_fped_2022_893045 crossref_primary_10_1097_MCP_0000000000000769 crossref_primary_10_1111_cas_15514 crossref_primary_10_1002_cti2_1217 crossref_primary_10_1186_s40478_022_01502_9 crossref_primary_10_3389_fendo_2021_596518 crossref_primary_10_1002_jmv_26891 crossref_primary_10_1016_j_arr_2021_101494 crossref_primary_10_1038_s41467_022_34655_1 crossref_primary_10_1093_gerona_glab078 crossref_primary_10_3389_fnano_2021_644023 crossref_primary_10_12688_f1000research_27287_2 crossref_primary_10_1038_s41598_021_91754_7 crossref_primary_10_2147_BTT_S404421 crossref_primary_10_1021_acsami_4c00838 crossref_primary_10_1128_spectrum_01504_21 crossref_primary_10_1038_s41392_021_00754_6 crossref_primary_10_1016_j_btre_2022_e00749 crossref_primary_10_1097_FM9_0000000000000190 crossref_primary_10_3389_fimmu_2022_951107 crossref_primary_10_3390_cells11121978 crossref_primary_10_1007_s11606_020_06494_7 crossref_primary_10_1080_22221751_2022_2049982 crossref_primary_10_4103_ejh_ejh_3_22 crossref_primary_10_31083_j_fbl2703102 crossref_primary_10_1016_j_heliyon_2023_e23320 crossref_primary_10_3390_ijms241914800 crossref_primary_10_1080_20009666_2021_1890340 crossref_primary_10_1016_j_isci_2022_103854 crossref_primary_10_1038_s41467_024_53059_x crossref_primary_10_3389_fimmu_2022_912336 crossref_primary_10_1016_j_clim_2023_109808 crossref_primary_10_1089_omi_2021_0182 crossref_primary_10_1007_s13365_021_00980_2 crossref_primary_10_1038_s41392_021_00703_3 crossref_primary_10_3389_fragi_2023_1108149 crossref_primary_10_1016_j_omtm_2022_02_012 crossref_primary_10_1038_s41392_021_00496_5 crossref_primary_10_1038_s41598_021_90983_0 crossref_primary_10_3390_biology12070947 crossref_primary_10_1016_j_kint_2021_05_032 crossref_primary_10_1038_s41467_021_26137_7 crossref_primary_10_3324_haematol_2022_281946 crossref_primary_10_3389_fcimb_2021_646688 crossref_primary_10_3389_fimmu_2021_789317 crossref_primary_10_2174_1570162X18666201201093540 crossref_primary_10_1038_s41598_024_70929_y crossref_primary_10_3389_fimmu_2021_710217 |
| Cites_doi | 10.1016/S0140-6736(20)30300-7 10.1001/jama.2020.1585 10.1038/s41586-020-2008-3 10.1016/S0140-6736(20)30305-6 10.1038/nrmicro.2016.81 10.1080/22221751.2020.1719902 10.1016/S2213-2600(20)30076-X 10.1016/S2213-2600(20)30127-2 10.1038/s41586-020-2012-7 10.1056/NEJMoa2001017 10.1093/nsr/nwaa041 10.1038/s41590-018-0210-3 10.1371/journal.ppat.1005909 10.1016/S0140-6736(20)30154-9 10.1038/s41467-019-08304-z 10.1007/s00281-017-0629-x 10.1093/cid/civ118 10.1038/ncomms7833 10.1038/s41392-020-0148-4 10.1186/cc10112 10.1007/s11427-020-1637-5 10.1038/s41586-020-2196-x 10.1016/S0140-6736(20)30211-7 10.1016/S0140-6736(20)30251-8 10.1016/S2213-2600(20)30079-5 10.1016/S0140-6736(20)30183-5 10.1056/NEJMc2001737 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020 The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2020 – notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU COVID DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM DOA |
| DOI | 10.1038/s41467-020-17240-2 |
| DatabaseName | Springer Nature OA/Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College Coronavirus Research Database ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2041-1723 |
| EndPage | 10 |
| ExternalDocumentID | oai_doaj_org_article_f394b906bb734d0da841b3a0209b27e6 PMC7343781 32641700 10_1038_s41467_020_17240_2 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GeographicLocations | China |
| GeographicLocations_xml | – name: China |
| GroupedDBID | --- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AARCD AZQEC C1K COVID DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 SOI 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c606t-4d2691ecae1081265d89d922e703b9ed9acf9929d5022bb259b4c5ac0f82a3323 |
| IEDL.DBID | M48 |
| ISSN | 2041-1723 |
| IngestDate | Wed Aug 27 01:28:15 EDT 2025 Thu Aug 21 17:51:24 EDT 2025 Fri Jul 11 08:02:52 EDT 2025 Wed Aug 13 08:06:11 EDT 2025 Mon Jul 21 06:02:23 EDT 2025 Tue Jul 01 04:09:00 EDT 2025 Thu Apr 24 23:03:36 EDT 2025 Fri Feb 21 02:40:03 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c606t-4d2691ecae1081265d89d922e703b9ed9acf9929d5022bb259b4c5ac0f82a3323 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
| ORCID | 0000-0002-1076-2979 0000-0002-8436-8077 0000-0002-8043-6685 0000-0003-4781-4477 0000-0002-8582-8012 0000-0002-0809-9207 |
| OpenAccessLink | https://www.nature.com/articles/s41467-020-17240-2 |
| PMID | 32641700 |
| PQID | 2421243366 |
| PQPubID | 546298 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_f394b906bb734d0da841b3a0209b27e6 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7343781 proquest_miscellaneous_2422013321 proquest_journals_2421243366 pubmed_primary_32641700 crossref_primary_10_1038_s41467_020_17240_2 crossref_citationtrail_10_1038_s41467_020_17240_2 springer_journals_10_1038_s41467_020_17240_2 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-07-08 |
| PublicationDateYYYYMMDD | 2020-07-08 |
| PublicationDate_xml | – month: 07 year: 2020 text: 2020-07-08 day: 08 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationTitleAlternate | Nat Commun |
| PublicationYear | 2020 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | ChenNEpidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive studyLancet20203955075131:CAS:528:DC%2BB3cXhvFOmsb8%3D10.1016/S0140-6736(20)30211-7 MackrothMSAbelASteegCSchulze Zur WieschJJacobsTAcute malaria induces PD1+CTLA4+ effector T cells with cell-extrinsic suppressor functionPLoS Pathog.201612e100590910.1371/journal.ppat.1005909 WangZRecovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cellsNat. Commun.201562015NatCo...6.6833W1:CAS:528:DC%2BC2MXhtF2ksbvF10.1038/ncomms7833 WuFA new coronavirus associated with human respiratory disease in ChinaNature20205792652692020Natur.579..265W1:CAS:528:DC%2BB3cXksFKlsLc%3D10.1038/s41586-020-2008-3 ZhuNA novel coronavirus from patients with pneumonia in China, 2019N. Engl. J. Med.20203827277331:CAS:528:DC%2BB3cXjslGmsrc%3D10.1056/NEJMoa2001017 TanLLymphopenia predicts disease severity of COVID-19: a descriptive and predictive studySignal Transduct. Target Ther.20205331:CAS:528:DC%2BB3cXlvV2rtrw%3D10.1038/s41392-020-0148-4 ChanJFGenomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting WuhanEmerg. Microbes Infect.202092212361:CAS:528:DC%2BB3cXotFOktLg%3D10.1080/22221751.2020.1719902 CamposJLSMongkolsapayaJScreatonGRThe immune response against flavivirusesNat. Immunol.2018191189119810.1038/s41590-018-0210-3 RasmussenSAGerberSISwerdlowDLMiddle East respiratory syndrome coronavirus: update for cliniciansClin. Infect. Dis.2015601686168910.1093/cid/civ118 ZhouPA pneumonia outbreak associated with a new coronavirus of probable bat originNature20205792702732020Natur.579..270Z1:CAS:528:DC%2BB3cXksFKlsLg%3D10.1038/s41586-020-2012-7 LuRGenomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor bindingLancet20203955655741:CAS:528:DC%2BB3cXhvFOmsLY%3D10.1016/S0140-6736(20)30251-8 CafriGMemory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patientsNat. Commun.2019102019NatCo..10..449C1:CAS:528:DC%2BC1MXntFersLg%3D10.1038/s41467-019-08304-z YangXClinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational studyLancet Respir. Med.202084754811:CAS:528:DC%2BB3cXjvVWqt70%3D10.1016/S2213-2600(20)30079-5 ChannappanavarRPerlmanSPathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathologySemin. Immunopathol.2017395295391:CAS:528:DC%2BC2sXntVGquro%3D10.1007/s00281-017-0629-x ZouLSARS-CoV-2 viral load in upper respiratory specimens of infected patientsN. Engl. J. Med.20203821177117910.1056/NEJMc2001737 WangFSZhangCWhat to do next to control the 2019-nCoV epidemic?Lancet20203953913931:CAS:528:DC%2BB3cXnsVais7k%3D10.1016/S0140-6736(20)30300-7 ZumlaAHuiDSAzharEIMemishZAMaeurerMReducing mortality from 2019-nCoV: host-directed therapies should be an optionLancet2020395e35e361:CAS:528:DC%2BB3cXisFagtro%3D10.1016/S0140-6736(20)30305-6 Zhou, Y. et al. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. Natl Sci. Rev. https://doi.org/10.1093/nsr/nwaa041 (2020). Wölfel, R. et al. Virological assessment of hospitalized patients with COVID-2019. Naturehttps://doi.org/10.1038/s41586-020-2196-x (2020). MatthayMAAldrichJMGottsJETreatment for severe acute respiratory distress syndrome from COVID-19Lancet Respir. Med.202084334341:CAS:528:DC%2BB3cXls1CmsLg%3D10.1016/S2213-2600(20)30127-2 WangDClinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, ChinaJAMA2020323106110691:CAS:528:DC%2BB3cXlvVSqtbY%3D10.1001/jama.2020.1585 XuXEvolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmissionSci. China Life Sci.2020634574601:CAS:528:DC%2BB3cXkt1ert70%3D10.1007/s11427-020-1637-5 XuZPathological findings of COVID-19 associated with acute respiratory distress syndromeLancet Respir. Med.202084204221:CAS:528:DC%2BB3cXjsValtbk%3D10.1016/S2213-2600(20)30076-X World Health Organization. Coronavirus disease 2019 (COVID-19) situation report—157. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200625-covid-19-sitrep-157.pdf?sfvrsn=423f4a82_2 (2020). GuignantCProgrammed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patientsCrit. Care20111510.1186/cc10112 de WitEvan DoremalenNFalzaranoDMunsterVJSARS and MERS: recent insights into emerging coronavirusesNat. Rev. Microbiol.20161452353410.1038/nrmicro.2016.81 ChanJFA familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family clusterLancet20203955145231:CAS:528:DC%2BB3cXhs1Ojsro%3D10.1016/S0140-6736(20)30154-9 HuangCClinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaLancet20203954975061:CAS:528:DC%2BB3cXhs1Kqu7c%3D10.1016/S0140-6736(20)30183-5 C Guignant (17240_CR24) 2011; 15 JLS Campos (17240_CR22) 2018; 19 F Wu (17240_CR9) 2020; 579 MA Matthay (17240_CR27) 2020; 8 C Huang (17240_CR5) 2020; 395 E de Wit (17240_CR23) 2016; 14 P Zhou (17240_CR12) 2020; 579 Z Xu (17240_CR10) 2020; 8 17240_CR1 R Lu (17240_CR6) 2020; 395 FS Wang (17240_CR8) 2020; 395 X Yang (17240_CR11) 2020; 8 X Xu (17240_CR16) 2020; 63 G Cafri (17240_CR26) 2019; 10 Z Wang (17240_CR21) 2015; 6 JF Chan (17240_CR2) 2020; 9 L Zou (17240_CR17) 2020; 382 L Tan (17240_CR20) 2020; 5 17240_CR18 MS Mackroth (17240_CR25) 2016; 12 N Zhu (17240_CR13) 2020; 382 17240_CR19 R Channappanavar (17240_CR14) 2017; 39 JF Chan (17240_CR3) 2020; 395 SA Rasmussen (17240_CR15) 2015; 60 N Chen (17240_CR4) 2020; 395 D Wang (17240_CR7) 2020; 323 A Zumla (17240_CR28) 2020; 395 |
| References_xml | – reference: de WitEvan DoremalenNFalzaranoDMunsterVJSARS and MERS: recent insights into emerging coronavirusesNat. Rev. Microbiol.20161452353410.1038/nrmicro.2016.81 – reference: ChanJFGenomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting WuhanEmerg. Microbes Infect.202092212361:CAS:528:DC%2BB3cXotFOktLg%3D10.1080/22221751.2020.1719902 – reference: World Health Organization. Coronavirus disease 2019 (COVID-19) situation report—157. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200625-covid-19-sitrep-157.pdf?sfvrsn=423f4a82_2 (2020). – reference: ChenNEpidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive studyLancet20203955075131:CAS:528:DC%2BB3cXhvFOmsb8%3D10.1016/S0140-6736(20)30211-7 – reference: MackrothMSAbelASteegCSchulze Zur WieschJJacobsTAcute malaria induces PD1+CTLA4+ effector T cells with cell-extrinsic suppressor functionPLoS Pathog.201612e100590910.1371/journal.ppat.1005909 – reference: WuFA new coronavirus associated with human respiratory disease in ChinaNature20205792652692020Natur.579..265W1:CAS:528:DC%2BB3cXksFKlsLc%3D10.1038/s41586-020-2008-3 – reference: WangZRecovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cellsNat. Commun.201562015NatCo...6.6833W1:CAS:528:DC%2BC2MXhtF2ksbvF10.1038/ncomms7833 – reference: CamposJLSMongkolsapayaJScreatonGRThe immune response against flavivirusesNat. Immunol.2018191189119810.1038/s41590-018-0210-3 – reference: TanLLymphopenia predicts disease severity of COVID-19: a descriptive and predictive studySignal Transduct. Target Ther.20205331:CAS:528:DC%2BB3cXlvV2rtrw%3D10.1038/s41392-020-0148-4 – reference: ChannappanavarRPerlmanSPathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathologySemin. Immunopathol.2017395295391:CAS:528:DC%2BC2sXntVGquro%3D10.1007/s00281-017-0629-x – reference: MatthayMAAldrichJMGottsJETreatment for severe acute respiratory distress syndrome from COVID-19Lancet Respir. Med.202084334341:CAS:528:DC%2BB3cXls1CmsLg%3D10.1016/S2213-2600(20)30127-2 – reference: LuRGenomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor bindingLancet20203955655741:CAS:528:DC%2BB3cXhvFOmsLY%3D10.1016/S0140-6736(20)30251-8 – reference: XuZPathological findings of COVID-19 associated with acute respiratory distress syndromeLancet Respir. Med.202084204221:CAS:528:DC%2BB3cXjsValtbk%3D10.1016/S2213-2600(20)30076-X – reference: ChanJFA familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family clusterLancet20203955145231:CAS:528:DC%2BB3cXhs1Ojsro%3D10.1016/S0140-6736(20)30154-9 – reference: Zhou, Y. et al. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. Natl Sci. Rev. https://doi.org/10.1093/nsr/nwaa041 (2020). – reference: Wölfel, R. et al. Virological assessment of hospitalized patients with COVID-2019. Naturehttps://doi.org/10.1038/s41586-020-2196-x (2020). – reference: WangFSZhangCWhat to do next to control the 2019-nCoV epidemic?Lancet20203953913931:CAS:528:DC%2BB3cXnsVais7k%3D10.1016/S0140-6736(20)30300-7 – reference: ZhuNA novel coronavirus from patients with pneumonia in China, 2019N. Engl. J. Med.20203827277331:CAS:528:DC%2BB3cXjslGmsrc%3D10.1056/NEJMoa2001017 – reference: ZhouPA pneumonia outbreak associated with a new coronavirus of probable bat originNature20205792702732020Natur.579..270Z1:CAS:528:DC%2BB3cXksFKlsLg%3D10.1038/s41586-020-2012-7 – reference: ZouLSARS-CoV-2 viral load in upper respiratory specimens of infected patientsN. Engl. J. Med.20203821177117910.1056/NEJMc2001737 – reference: CafriGMemory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patientsNat. Commun.2019102019NatCo..10..449C1:CAS:528:DC%2BC1MXntFersLg%3D10.1038/s41467-019-08304-z – reference: WangDClinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, ChinaJAMA2020323106110691:CAS:528:DC%2BB3cXlvVSqtbY%3D10.1001/jama.2020.1585 – reference: YangXClinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational studyLancet Respir. Med.202084754811:CAS:528:DC%2BB3cXjvVWqt70%3D10.1016/S2213-2600(20)30079-5 – reference: HuangCClinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaLancet20203954975061:CAS:528:DC%2BB3cXhs1Kqu7c%3D10.1016/S0140-6736(20)30183-5 – reference: RasmussenSAGerberSISwerdlowDLMiddle East respiratory syndrome coronavirus: update for cliniciansClin. Infect. Dis.2015601686168910.1093/cid/civ118 – reference: XuXEvolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmissionSci. China Life Sci.2020634574601:CAS:528:DC%2BB3cXkt1ert70%3D10.1007/s11427-020-1637-5 – reference: ZumlaAHuiDSAzharEIMemishZAMaeurerMReducing mortality from 2019-nCoV: host-directed therapies should be an optionLancet2020395e35e361:CAS:528:DC%2BB3cXisFagtro%3D10.1016/S0140-6736(20)30305-6 – reference: GuignantCProgrammed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patientsCrit. Care20111510.1186/cc10112 – volume: 395 start-page: 391 year: 2020 ident: 17240_CR8 publication-title: Lancet doi: 10.1016/S0140-6736(20)30300-7 – volume: 323 start-page: 1061 year: 2020 ident: 17240_CR7 publication-title: JAMA doi: 10.1001/jama.2020.1585 – volume: 579 start-page: 265 year: 2020 ident: 17240_CR9 publication-title: Nature doi: 10.1038/s41586-020-2008-3 – volume: 395 start-page: e35 year: 2020 ident: 17240_CR28 publication-title: Lancet doi: 10.1016/S0140-6736(20)30305-6 – volume: 14 start-page: 523 year: 2016 ident: 17240_CR23 publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro.2016.81 – volume: 9 start-page: 221 year: 2020 ident: 17240_CR2 publication-title: Emerg. Microbes Infect. doi: 10.1080/22221751.2020.1719902 – volume: 8 start-page: 420 year: 2020 ident: 17240_CR10 publication-title: Lancet Respir. Med. doi: 10.1016/S2213-2600(20)30076-X – volume: 8 start-page: 433 year: 2020 ident: 17240_CR27 publication-title: Lancet Respir. Med. doi: 10.1016/S2213-2600(20)30127-2 – volume: 579 start-page: 270 year: 2020 ident: 17240_CR12 publication-title: Nature doi: 10.1038/s41586-020-2012-7 – ident: 17240_CR1 – volume: 382 start-page: 727 year: 2020 ident: 17240_CR13 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2001017 – ident: 17240_CR19 doi: 10.1093/nsr/nwaa041 – volume: 19 start-page: 1189 year: 2018 ident: 17240_CR22 publication-title: Nat. Immunol. doi: 10.1038/s41590-018-0210-3 – volume: 12 start-page: e1005909 year: 2016 ident: 17240_CR25 publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1005909 – volume: 395 start-page: 514 year: 2020 ident: 17240_CR3 publication-title: Lancet doi: 10.1016/S0140-6736(20)30154-9 – volume: 10 year: 2019 ident: 17240_CR26 publication-title: Nat. Commun. doi: 10.1038/s41467-019-08304-z – volume: 39 start-page: 529 year: 2017 ident: 17240_CR14 publication-title: Semin. Immunopathol. doi: 10.1007/s00281-017-0629-x – volume: 60 start-page: 1686 year: 2015 ident: 17240_CR15 publication-title: Clin. Infect. Dis. doi: 10.1093/cid/civ118 – volume: 6 year: 2015 ident: 17240_CR21 publication-title: Nat. Commun. doi: 10.1038/ncomms7833 – volume: 5 start-page: 33 year: 2020 ident: 17240_CR20 publication-title: Signal Transduct. Target Ther. doi: 10.1038/s41392-020-0148-4 – volume: 15 year: 2011 ident: 17240_CR24 publication-title: Crit. Care doi: 10.1186/cc10112 – volume: 63 start-page: 457 year: 2020 ident: 17240_CR16 publication-title: Sci. China Life Sci. doi: 10.1007/s11427-020-1637-5 – ident: 17240_CR18 doi: 10.1038/s41586-020-2196-x – volume: 395 start-page: 507 year: 2020 ident: 17240_CR4 publication-title: Lancet doi: 10.1016/S0140-6736(20)30211-7 – volume: 395 start-page: 565 year: 2020 ident: 17240_CR6 publication-title: Lancet doi: 10.1016/S0140-6736(20)30251-8 – volume: 8 start-page: 475 year: 2020 ident: 17240_CR11 publication-title: Lancet Respir. Med. doi: 10.1016/S2213-2600(20)30079-5 – volume: 395 start-page: 497 year: 2020 ident: 17240_CR5 publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 – volume: 382 start-page: 1177 year: 2020 ident: 17240_CR17 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMc2001737 |
| SSID | ssj0000391844 |
| Score | 2.6868706 |
| Snippet | COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been... Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 3410 |
| SubjectTerms | 13/1 13/21 13/31 13/51 631/250/254 631/250/255/2514 631/250/256/2516 Adult Aged Aged, 80 and over Betacoronavirus - immunology Betacoronavirus - pathogenicity Biomarkers - metabolism CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell activation Chemotaxis, Leukocyte China - epidemiology Coronavirus Infections - blood Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 Cytokines - blood Cytotoxicity Epidemiology Female Humanities and Social Sciences Humans Immune system Immunology Inflammation Killer Cells, Natural - immunology Killer Cells, Natural - pathology Leukocyte Count Lung - immunology Lung - virology Lymphocyte Activation Lymphocytes Lymphocytes T Lymphopenia Macrophages Male Middle Aged multidisciplinary Pandemics Pathogenesis Patients Pneumonia, Viral - blood Pneumonia, Viral - immunology Pneumonia, Viral - pathology Pneumonia, Viral - virology Ribonucleic acid RNA SARS-CoV-2 Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Therapeutic applications Toxicity Viral diseases |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELYQEhIXVFoeKdvKlbhRaxM_kvgIW9BSIbgUxM3yU11pyVbscuDfM3ayCwsULlxjJxrNjP3NZOxvENp31BoNsEoq6SrCAZOI9EwSyW0tBEAOC-mA7Hk5vOS_r8X1k1Zf8UxYSw_cKq4fmORG5qUxFeMud7rmhWEaohxpaOUT2TZg3pNkKu3BTELqwrtbMjmr-1Oe9oSYLQFm85zQJSRKhP2vRZkvD0s-q5gmIDr5hDa6CBIftpJvohXffEZrbU_J-y_o7DTe-JhvaVg3DoMTgd1vUj0dd026p_AU34zGLs0AePS3HluAtCmeBDy4uDr9RQq5hS5Pjv8MhqRrmUAsZCIzwh0tZeGt9gVgPS2Fq6WTlHpY2EZ6J7UNEiIiJwC7jYHcx3ArtM1DTTVjlG2j1WbS-F2ERV6EglpaiUjSZ7XRkW2MiRByDXYIGSrm6lO24xOPbS3GKtW1Wa1alStQuUoqVzRDB4t3_rVsGm_OPopWWcyMTNjpAfiH6vxDvecfGerNbaq65TlVqQ7OGSth-MdiGBZWrJboxk_u0hwIjkAnRYZ2WhdYSAIxL4_EhhmqlpxjSdTlkWb0N5F3g5SsquGbP-du9CjW_1Xx9SNUsYfWafT_-HO67qHV2e2d_wYh1cx8T6vnAdzdF-g priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Jb9UwELagCIkLYidQUJC4gdXES2yfEBSqFiG4UPRulleo1Cbl5fXAv2fsOKkeS6-OY03GM_7GHucbhF564qwBWMVCeYEZYBJWgSqsmJOcA-TQmC_Ifu4Oj9nHFV-VA7exXKuc18S8UPvBpTPyvZy6ZJR23ZvznzhVjUrZ1VJC4zq6kajL0pUusRLLGUtiP5eMlX9lGir3RpZXhrRnAuRmDSZbeJRp-_8Va_59ZfKPvGmGo4M76HaJI-u308TfRddCfw_dnCpL_rqPPh2l_z7mha02va_BlGD2z3JWvS6lukdorc9OTn3uASAZ1qF2AGxjPcR6_8u3o_e4VQ_Q8cGHr_uHuBROwA72IxvMPOlUG5wJLSA-6biXyitCAri3VcEr46KCuMhzQHBrYQdkmePGNVESQymhD9FOP_ThMap508aWOCJ4oupzxprEOUZ5jI3xjY8Vamf1aVdYxVNxi1Ods9tU6knlGlSus8o1qdCr5Z3ziVPjyt7v0qwsPRMfdm4Y1t91cS8dqWJWNZ21gjKQy0jWWmpgGGWJCF2Fduc51cVJR31pUhV6sTwG90o5E9OH4SL3gRAJdNJW6NFkAoskEPmyRG9YIbFlHFuibj_pT35kCm-QkgoJY76ezehSrP-r4snVX_EU3SLJstPhs9xFO5v1RXgGIdPGPs9-8RsqDw-5 priority: 102 providerName: ProQuest – databaseName: Springer Nature OA/Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1baxUxEB5KRfBFvLu2SgTfNLiby27y2B4trYi-WOlbyFUL7R455_Sh_95J9iJHq-BrMrsMk5l8k0zyBeBVYN5ZhFXa6dBRgZhEdeSaauGVlAg5PJUDsp_a41Px4Uye7QCb7sKUQ_uF0rJM09PpsLdrUUI6L3YQckVNcdq9lanbs1cv2sW8r5IZz5UQ4_2YmqsbPt3CoELVf1N--ecxyd9qpQWCju7B3TF3JAeDtvdhJ_YP4PbwmuT1Q_h4ku96TJMZsX0g6D444pelkk7G57nX2Eouzy9CkUBgjKtIPILZmiwTWXz-evKONvoRnB69_7I4puNjCdTjGmRDRWCtbqK3sUGUZ60MSgfNWMSQdjoGbX3SmAsFiajtHK56nPDS-jopZjln_DHs9ss-PgUi6yY1zLNOZno-b53NPGNcplTbUIdUQTOZz_iRSTw_aHFhSkWbKzOY3KDJTTG5YRW8nr_5MfBo_FP6MI_KLJk5sEvDcvXNjD5hEtfC6bp1ruMC9bJKNI5b_I12rIttBfvTmJoxMNemVMAF5y12v5y7MaRyncT2cXlVZDAtQps0FTwZXGDWBLNdkSkNK-i2nGNL1e2e_vx7oe1GLXmn8J9vJjf6pdbfTfHs_8T34A7Lnp43oNU-7G5WV_E5pk0b96LEyU9Dmg17 priority: 102 providerName: Springer Nature |
| Title | Immunological and inflammatory profiles in mild and severe cases of COVID-19 |
| URI | https://link.springer.com/article/10.1038/s41467-020-17240-2 https://www.ncbi.nlm.nih.gov/pubmed/32641700 https://www.proquest.com/docview/2421243366 https://www.proquest.com/docview/2422013321 https://pubmed.ncbi.nlm.nih.gov/PMC7343781 https://doaj.org/article/f394b906bb734d0da841b3a0209b27e6 |
| Volume | 11 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwED-NTUi8IL4XGFWQeINAYjtx_DChrlvZKhgIKOqb5a_ApC6FtpO2_56zk3QqFMRLKtkX63q58-8uF98BPLfEaIWwmnBhecIQkxLhqEgEM2WeI-TQKnwge1ocj9lokk-2oGt31ApwsTG08_2kxvPpq8ufV2_Q4PebI-Pl6wUL5u4DIYRjlia4Je8gMnFvqO9bdz_szFRgQOMTzSRlmSem7TmazcusYVUo6b_JD_3zc8rfcqoBqoZ34HbrY8b9Rinuwpar78HNpuvk1X14d-LPhHSbXqxqG-MfR804Dxn3uG3jvcDR-PxsagMFAqibu9gg6C3iWRUPPnw9OUwy8QDGw6Mvg-OkbaqQGIxVlgmzpBCZM8pl6A2QIrelsIIQh6avhbNCmUqgz2RzRHetMTrSzOTKpFVJFKWEPoTtela7XYjzNKsyYgjPfRk_o7Ty9choXlWpsqmtIsg68UnTVhz3jS-mMmS-aSkbkUsUuQwilySCF6t7fjT1Nv5JfeCfyorS18oOA7P5N9manqyoYFqkhdacMuRLlSzTVOEyQhPuigj2umcqO_2TIVPOKC1w-tlqGk3P51NU7WYXgQbdJ5RJFsGjRgVWnKBXzHzpwwj4mnKssbo-U599D-W9kUvKS1zzZadG12z9XRSP_4PNJ3CLePX2b6fLPdhezi_cU_SplroHN_iE47Ucvu3BTr8_-jzC34Oj04-fcHRQDHrhbUUvGNQv5x0dcw |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB5VRQguiHcDBYwEJ4ia2M7DB4SgpdqlS7m0aG_Gr0ClNimbrVD_FL-RsfOolkdvvSbeaHb8zXxjjz0D8MJSoxXSalwIW8QcOSkWjolYcFNmGVIOq8IB2f18csg_zrP5Gvwa7sL4Y5WDTwyO2jbG75FvhdQlZyzP357-iH3XKJ9dHVpodLDYc-c_ccnWvpnu4Py-pHT3w8H2JO67CsQGg_VlzC3NReqMcinSIc0zWworKHWIfS2cFcpUAoMGmyG9aY3LA81NpkxSlVQx5gsdoMu_hsSbeIsq5sW4p-OrrZec93dzElZutTx4Ir9Gw0iBJzFd4b_QJuBfse3fRzT_yNMG-tu9Dbf6uJW864B2B9ZcfReud50sz-_BbOrvmQyOlKjaEoQuou0kZPFJ3xq8xafk5OjYhhFIym7hiEEibUlTke3PX6Y7cSruw-GVqPQBrNdN7TaAZElapdTQIvOlAY3Sytc4Y1lVJcomtoogHdQnTV_F3DfTOJYhm85K2alcosplULmkEbwaf3Pa1fC4dPR7PyvjSF9_OzxoFt9kb86yYoJrkeRaF4yjXKrkqWYKPyM0LVweweYwp7J3Cq28gHAEz8fXaM4-R6Nq15yFMRiSoU7SCB52EBglwUib-3KKERQr4FgRdfVNffQ9lAxHKVlR4jdfDzC6EOv_qnh0-b94BjcmB59mcjbd33sMN6lHud_4Ljdhfbk4c08wXFvqp8FGCHy9aqP8DUzsS_Y |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9QwFLaqIhAXxE6ggJHgBNYktrP4gBB0GHVoVThQNDfjFSq1SZlMhfrX-HU8O0s1LL31mniiN8_fW-xnfw-h55YarSCsklLYknCISUQ4JojgpspzCDnMxwOy-8XOAf-wyBcb6NdwFyYcqxx8YnTUtjFhj3wSS5ecsaKY-P5YxKfp7M3JDxI6SIVK69BOo4PIrjv7Ccu39vV8CnP9gtLZ-8_bO6TvMEAMJO4rwi0tROaMchmERlrkthJWUOrADrRwVijjBSQQNodQpzUsFTQ3uTKpr6hiLJAegPu_UrI8CzZWLspxfycwr1ec9_d0UlZNWh69UlivQdbAU0LXYmFsGfCvPPfv45p_1GxjKJzdRDf6HBa_7UB3C224-ja62nW1PLuD9ubhzsngVLGqLQYYA_KOY0Uf923CW3iKjw-PbBwBAdotHTYQVFvceLz98ct8SjJxFx1cikrvoc26qd0DhPM08xk1tMwDTaBRWgW-M5Z7nyqbWp-gbFCfND2jeWiscSRjZZ1VslO5BJXLqHJJE_Ry_M1Jx-dx4eh3YVbGkYGLOz5olt9kb9rSM8G1SAutS8ZBLlXxTDMFnxGalq5I0NYwp7J3EK08h3OCno2vwbRDvUbVrjmNYyA9A51kCbrfQWCUBLJuHqgVE1SugWNN1PU39eH3SB8OUrKygm--GmB0Ltb_VfHw4n_xFF0Dc5R78_3dR-g6DSAPe-DVFtpcLU_dY8jcVvpJNBGMvl62Tf4GBt9QLA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunological+and+inflammatory+profiles+in+mild+and+severe+cases+of+COVID-19&rft.jtitle=Nature+communications&rft.au=Song%2C+Jin-Wen&rft.au=Zhang%2C+Chao&rft.au=Fan%2C+Xing&rft.au=Meng%2C+Fan-Ping&rft.date=2020-07-08&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=11&rft.issue=1&rft.spage=3410&rft_id=info:doi/10.1038%2Fs41467-020-17240-2&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon |