Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells

• Published in: Scientific reports Vol. 12; no. 1; pp. 6522 - 14
• Main Authors: Suda, Masayoshi, Shimizu, Ippei, Katsuumi, Goro, Hsiao, Chieh Lun, Yoshida, Yohko, Matsumoto, Naomi, Yoshida, Yutaka, Katayama, Akihiro, Wada, Jun, Seki, Masahide, Suzuki, Yutaka, Okuda, Shujiro, Ozaki, Kazuyuki, Nakanishi-Matsui, Mayumi, Minamino, Tohru
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/1426; 692/4019/592; Aging; Animals; Antigens; Atherogenesis; Atherosclerosis; Cell cycle; Cellular Senescence; Endothelial cells; Endothelial Cells - metabolism; Eye Proteins - metabolism; Glycoproteins; Humanities and Social Sciences; Life span; Longevity; Lysosomes - metabolism; Melanoma; Melanoma - metabolism; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mice; multidisciplinary; Phenotypes; Protein B; Receptors, Fc; Science; Science (multidisciplinary); Senescence; Survival factor; Vaccination

Accumulation of senescent cells in various tissues has been reported to have a pathological role in age-associated diseases. Elimination of senescent cells (senolysis) was recently reported to reversibly improve pathological aging phenotypes without increasing rates of cancer. We previously identifi...