Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape

• Published in: Nature structural & molecular biology Vol. 21; no. 4; pp. 358 - 365
• Main Authors: Cecere, Germano, Hoersch, Sebastian, O'Keeffe, Sean, Sachidanandam, Ravi, Grishok, Alla
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2014; Nature Publishing Group
• Subjects: 38; 38/15; 45; 45/91; 631/337/505; 64; 64/11; Animals; Biochemistry; Biochemistry, Molecular Biology; Biological Microscopy; Caenorhabditis elegans; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins; Caenorhabditis elegans Proteins - metabolism; Caenorhabditis elegans Proteins - physiology; Chromatin; Chromatin - metabolism; Chromatin Assembly and Disassembly; Gene expression; Gene Expression Regulation; Genetic aspects; Genetic research; Genetic transcription; Genomics; Histones; Histones - metabolism; Life Sciences; Membrane Biology; Protein Structure; Ribonucleic acid; RNA; RNA Interference; RNA, Small Interfering; Signal transduction; Transcription, Genetic

RNAi pathways inhibit gene expression at the transcriptional and post-transcriptional level. Genome-wide analyses of nascent RNA transcripts in nematodes now suggest that the CSR-1 RNAi pathway helps maintain the directionality of active transcription and propagate the distinction between transcript...