Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model - Cen, Xufeng; Chen, Yanying; Xu, Xiaoyan; Wu, Ronghai; He, Fusheng; Zhao, Qingwei; Sun, Qiming; Yi, Cong; Wu, Jie; Najafov, Ayaz; Xia, Hongguang (Nature communications, 2020)
Keywords: 13; 14; 38; 49; 631/154/1435/2163; 631/378/1689/1283; 631/80/39/2348; 64/60; 82/83; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Animals; Apoptosis; Apoptosis - drug effects; Autophagy-Related Protein 5 - economics; Cell Survival; Disease Models, Animal; Drug development; Drugs; Gene Knockout Techniques; Glucose; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humanities and Social Sciences; Humans; Intracellular Signaling Peptides and Proteins; Libraries; Male; Mcl-1 protein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins - metabolism; Mitophagy; Mitophagy - drug effects; Mitophagy - physiology; multidisciplinary; Myeloid Cell Leukemia Sequence 1 Protein - drug effects; Myeloid Cell Leukemia Sequence 1 Protein - genetics; Myeloid Cell Leukemia Sequence 1 Protein - metabolism; Neoplasm Proteins; Nerve Tissue Proteins; Neurodegenerative diseases; Neurons - metabolism; Oxygen; Phenotypes; Presenilin 1; Receptors; Receptors, Cytoplasmic and Nuclear; Science; Science (multidisciplinary); Sulfonamides - pharmacology; Therapeutic targets; Thioglycolates - pharmacology