Evaluating dopamine transporter imaging as an enrichment biomarker in a phase 2 Parkinson’s disease trial - Hutchison, R. Matthew; Evans, Karleyton C.; Fox, Tara; Yang, Minhua; Barakos, Jerome; Bedell, Barry J.; Cedarbaum, Jesse M.; Brys, Miroslaw; Siderowf, Andrew; Lang, Anthony E. (BMC neurology, 2021)
Keywords: Basal ganglia; Biological markers; Biomarker; Biomarkers; Brain diseases; Carrier proteins; Central nervous system diseases; Clinical medicine; Clinical trials; Computed tomography; CT imaging; Diagnosis; Diagnostic imaging; Dopamine; Dopamine receptors; Dopamine transporter; Drug dosages; Drug therapy; FDA approval; Health aspects; Methods; Monoclonal antibodies; Movement disorders; Nerve endings; Neurodegenerative diseases; Parkinson's disease; Regulatory approval; Single photon emission computed tomography; SPECT; SWEDD; Synuclein; Testing; Thyroid gland; Tomography; Tremor (Muscular contraction); Work stations; United States; United States--US