Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

• Published in: Nature communications Vol. 13; no. 1; pp. 1745 - 13
• Main Authors: Rutkai, Ibolya, Mayer, Meredith G., Hellmers, Linh M., Ning, Bo, Huang, Zhen, Monjure, Christopher J., Coyne, Carol, Silvestri, Rachel, Golden, Nadia, Hensley, Krystle, Chandler, Kristin, Lehmicke, Gabrielle, Bix, Gregory J., Maness, Nicholas J., Russell-Lodrigue, Kasi, Hu, Tony Y., Roy, Chad J., Blair, Robert V., Bohm, Rudolf, Doyle-Meyers, Lara A., Rappaport, Jay, Fischer, Tracy
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 14/19; 14/32; 631/326/596/4130; 631/378/1689/2609/3183; 692/699/255/2514; Animal models; Animals; Apoptosis; Autopsies; Brain; Central nervous system; Coronaviruses; COVID-19; Degeneration; Endothelial Cells; Humanities and Social Sciences; Humans; Hypoxia; Infections; Inflammation; Ischemia; Long COVID; multidisciplinary; Neurodegeneration; Neuropathogenesis; Neuropathology; Primates; Respiratory diseases; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; Viral diseases; Viruses

Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren’t well understood. The development of animal models that recapitulate the neuropathological findings of autopsied brain tissue from patients who died from severe acute respira...