Efficient assembly of nanopore reads via highly accurate and intact error correction

• Published in: Nature communications Vol. 12; no. 1; pp. 60 - 10
• Main Authors: Chen, Ying, Nie, Fan, Xie, Shang-Qian, Zheng, Ying-Feng, Dai, Qi, Bray, Thomas, Wang, Yao-Xin, Xing, Jian-Feng, Huang, Zhi-Jian, Wang, De-Peng, He, Li-Juan, Luo, Feng, Wang, Jian-Xin, Liu, Yi-Zhi, Xiao, Chuan-Le
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 45/23; 631/114/2397; 631/208/212/2302; 631/208/514/1948; Assembling; Assembly; Cell Line; Chromosomes, Human - genetics; Error correction; Error correction & detection; Error reduction; Genome, Human; Genomes; Humanities and Social Sciences; Humans; multidisciplinary; Nanopores; Porosity; Retinoblastoma - genetics; Science; Science (multidisciplinary); Sequence Analysis, DNA; Software

Long nanopore reads are advantageous in de novo genome assembly. However, nanopore reads usually have broad error distribution and high-error-rate subsequences. Existing error correction tools cannot correct nanopore reads efficiently and effectively. Most methods trim high-error-rate subsequences d...