Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

• Published in: Scientific reports Vol. 11; no. 1; pp. 518 - 11
• Main Authors: Zhang, Wenchao, Miikeda, Aika, Zuckerman, Jonathan, Jia, Xun, Charugundla, Sarada, Zhou, Zhiqiang, Kaczor-Urbanowicz, Karolina Elżbieta, Magyar, Clara, Guo, Fangfei, Wang, Zeneng, Pellegrini, Matteo, Hazen, Stanley L., Nicholas, Susanne B., Lusis, Aldons J., Shih, Diana M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 631/80; 692/4019; 692/4022; 692/699; Adenine; Adenine - administration & dosage; Adenine - adverse effects; Albuminuria - etiology; Animal models; Animals; Aorta; Apolipoprotein E; Arteriosclerosis; Cardiomegaly - etiology; Cardiomegaly - prevention & control; Cardiovascular disease; Cardiovascular diseases; Choline; Choline - administration & dosage; Choline - adverse effects; Choline - analogs & derivatives; Choline - pharmacology; Creatinine; Cystatin C; Dietary supplements; Disease Models, Animal; Female; Fibroblast Growth Factor-23; Fibrosis; Gastrointestinal Microbiome - physiology; Humanities and Social Sciences; Hypertrophy; Inflammation; Kidney - pathology; Kidney diseases; Kidneys; Metabolites; Methylamines - administration & dosage; Methylamines - adverse effects; Methylamines - metabolism; Mice; Microbiota; multidisciplinary; Plasma levels; Renal Insufficiency, Chronic - etiology; Renal Insufficiency, Chronic - pathology; Renal Insufficiency, Chronic - prevention & control; Science; Science (multidisciplinary); Trimethylamine
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-80063-0

Patients with chronic kidney disease (CKD) have elevated circulating levels of trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with cardiovascular diseases. High circulating levels of TMAO and its dietary precursor, choline, predict increased risk for development...