Effects of fatty acid metabolites on nocturia

• Published in: Scientific reports Vol. 12; no. 1; pp. 3050 - 10
• Main Authors: Ihara, Tatsuya, Shimura, Hiroshi, Tsuchiya, Sachiko, Kanda, Mie, Kira, Satoru, Sawada, Norifumi, Takeda, Masayuki, Mitsui, Takahiko, Shigetomi, Eiji, Shinozaki, Yoichi, Koizumi, Schuichi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.02.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443/319; 631/443/319/2723; 692/4025; 692/4025/2768; Amides - administration & dosage; Amides - blood; Animals; Circadian Rhythm; Circadian rhythms; CLOCK Proteins - genetics; Disease Models, Animal; Docosahexaenoic acid; Docosahexaenoic Acids - administration & dosage; Docosahexaenoic Acids - blood; Ethanolamines - administration & dosage; Ethanolamines - blood; Fatty acids; Fatty Acids - administration & dosage; Fatty Acids - metabolism; Humanities and Social Sciences; Injections, Intraperitoneal; Linoleic Acids, Conjugated - administration & dosage; Linoleic Acids, Conjugated - blood; Lipids; Male; Metabolites; Mice; Mice, Inbred C57BL; multidisciplinary; Nocturia; Nocturia - blood; Nocturia - genetics; Nocturia - metabolism; Palmitic Acids - administration & dosage; Palmitic Acids - blood; Palmitoylethanolamide; Photoperiod; Science; Science (multidisciplinary); Urinary Bladder - pathology; Urination - genetics

Dysregulation of circadian rhythm can cause nocturia. Levels of fatty acid metabolites, such as palmitoylethanolamide (PEA), 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE), and 4-hydroxy-5E,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid (4-HDoHE), are higher in the serum of patients with nocturia; however...