Genotype I of Japanese Encephalitis Virus Virus-like Particles Elicit Sterilizing Immunity against Genotype I and III Viral Challenge in Swine

• Published in: Scientific reports Vol. 8; no. 1; pp. 7481 - 10
• Main Authors: Fan, Yi-Chin, Chen, Jo-Mei, Lin, Jen-Wei, Chen, Yi-Ying, Wu, Guan-Hong, Su, Kuan-Hsuan, Chiou, Ming-Tang, Wu, Shang-Rung, Yin, Ji-Hang, Liao, Jiunn-Wang, Chang, Gwong-Jen J., Chiou, Shyan-Song
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.05.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 631/326/590/2294; 631/326/596/2563; 631/326/596/2564; 64/60; 82/29; 82/80; 82/83; 96; Cell fusion; Cytology; Encephalitis; Fever; Genotype & phenotype; Genotypes; Heparan sulfate; Humanities and Social Sciences; Immunity; Immunization; Immunogenicity; Lymph nodes; multidisciplinary; Neutralization; Outbreaks; Ribonucleic acid; RNA; Science; Science (multidisciplinary); Sulfates; Vaccines; Vector-borne diseases; Viremia; Virus-like particles; Viruses

Swine are a critical amplifying host involved in human Japanese encephalitis (JE) outbreaks. Cross-genotypic immunogenicity and sterile protection are important for the current genotype III (GIII) virus-derived vaccines in swine, especially now that emerging genotype I (GI) JE virus (JEV) has replac...