Odor-evoked inhibition of olfactory sensory neurons drives olfactory perception in Drosophila

• Published in: Nature communications Vol. 8; no. 1; pp. 1357 - 14
• Main Authors: Cao, Li-Hui, Yang, Dong, Wu, Wei, Zeng, Xiankun, Jing, Bi-Yang, Li, Meng-Tong, Qin, Shanshan, Tang, Chao, Tu, Yuhai, Luo, Dong-Gen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.11.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/2624/2625; 631/378/3917; Animals; Animals, Genetically Modified; Coding; Drosophila; Drosophila melanogaster - physiology; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Excitation; Female; Gene Knockout Techniques; Humanities and Social Sciences; Insects; Male; multidisciplinary; Nervous system; Neural coding; Neurons; Odorant receptors; Odorants; Odors; Olfactory perception; Olfactory Perception - physiology; Olfactory receptor neurons; Olfactory Receptor Neurons - physiology; Olfactory system; Optogenetics - methods; Patch-Clamp Techniques; Receptors; Receptors, Odorant - genetics; Receptors, Odorant - metabolism; Science; Science (multidisciplinary); Sensory evaluation; Sensory neurons; Smell

Inhibitory response occurs throughout the nervous system, including the peripheral olfactory system. While odor-evoked excitation in peripheral olfactory cells is known to encode odor information, the molecular mechanism and functional roles of odor-evoked inhibition remain largely unknown. Here, we...